U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Untreated Metastatic Squamous Cell Carcinoma to Neck with Occult Primary

MedGen UID:
856811
•Concept ID:
C3897217
•
Finding

Definition

A finding of metastatic squamous cell carcinoma to neck with occult primary that has not been treated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUntreated Metastatic Squamous Cell Carcinoma to Neck with Occult Primary

Professional guidelines

PubMed

The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+.
Layland MK, Sessions DG, Lenox J
Laryngoscope 2005 Apr;115(4):629-39. doi: 10.1097/01.mlg.0000161338.54515.b1. PMID: 15805872
Surgical treatment of squamous cell carcinoma of the base of tongue.
Gourin CG, Johnson JT
Head Neck 2001 Aug;23(8):653-60. doi: 10.1002/hed.1092. PMID: 11443748
Effectiveness of selective neck dissection for management of the clinically negative neck.
Pitman KT, Johnson JT, Myers EN
Arch Otolaryngol Head Neck Surg 1997 Sep;123(9):917-22. doi: 10.1001/archotol.1997.01900090023004. PMID: 9305240

Recent clinical studies

Etiology

Sentinel node biopsy using indocyanine green in oral/oropharyngeal cancer.
Peng H, Wang SJ, Niu X, Yang X, Chi C, Zhang G
World J Surg Oncol 2015 Sep 17;13:278. doi: 10.1186/s12957-015-0691-6. PMID: 26381239Free PMC Article
Unilateral, clinically T2N0, squamous cell carcinoma of the tongue: surgical outcome analysis.
Lim YC, Choi EC
Int J Oral Maxillofac Surg 2007 Jul;36(7):610-4. Epub 2007 Mar 6 doi: 10.1016/j.ijom.2007.01.009. PMID: 17344023
Relevance of skip metastases for squamous cell carcinoma of the oral tongue and the floor of the mouth.
Dias FL, Lima RA, Kligerman J, Farias TP, Soares JR, Manfro G, Sa GM
Otolaryngol Head Neck Surg 2006 Mar;134(3):460-5. doi: 10.1016/j.otohns.2005.09.025. PMID: 16500445
Surgical treatment of squamous cell carcinoma of the base of tongue.
Gourin CG, Johnson JT
Head Neck 2001 Aug;23(8):653-60. doi: 10.1002/hed.1092. PMID: 11443748
The significance of DNA flow cytometry in predicting survival and delayed clinical manifestation of occult lymph node metastasis to the untreated neck in patients with oral squamous cell carcinoma.
Hemmer J, Kraft K, Kreidler J
J Craniomaxillofac Surg 1998 Dec;26(6):405-10. doi: 10.1016/s1010-5182(98)80076-0. PMID: 10036659

Diagnosis

Use of a novel receptor-targeted (CD206) radiotracer, 99mTc-tilmanocept, and SPECT/CT for sentinel lymph node detection in oral cavity squamous cell carcinoma: initial institutional report in an ongoing phase 3 study.
Marcinow AM, Hall N, Byrum E, Teknos TN, Old MO, Agrawal A
JAMA Otolaryngol Head Neck Surg 2013 Sep;139(9):895-902. doi: 10.1001/jamaoto.2013.4239. PMID: 24051744Free PMC Article
99mTc(V)-dimercaptosuccinic acid scintigraphy in detecting neck metastases in oral squamous cell carcinoma with clinically negative necks.
Zhang Y, Guo C, Yu G, Zhang C
Oral Oncol 2009 Jun;45(6):492-5. Epub 2008 Oct 11 doi: 10.1016/j.oraloncology.2008.06.008. PMID: 18849187
CT of the chest and abdomen in patients with newly diagnosed head and neck squamous cell carcinoma.
Keski-Säntti HT, Markkola AT, Mäkitie AA, Bäck LJ, Atula TS
Head Neck 2005 Oct;27(10):909-15. doi: 10.1002/hed.20259. PMID: 16114003
The diagnostic value of ultrasonography to detect occult lymph node involvement at different levels in patients with squamous cell carcinoma in the maxillofacial region.
Jank S, Robatscher P, Emshoff R, Strobl H, Gojer G, Norer B
Int J Oral Maxillofac Surg 2003 Feb;32(1):39-42. doi: 10.1054/ijom.2002.0326. PMID: 12653231
Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?
Byers RM, El-Naggar AK, Lee YY, Rao B, Fornage B, Terry NH, Sample D, Hankins P, Smith TL, Wolf PJ
Head Neck 1998 Mar;20(2):138-44. doi: 10.1002/(sici)1097-0347(199803)20:2<138::aid-hed7>3.0.co;2-3. PMID: 9484945

Therapy

Use of a novel receptor-targeted (CD206) radiotracer, 99mTc-tilmanocept, and SPECT/CT for sentinel lymph node detection in oral cavity squamous cell carcinoma: initial institutional report in an ongoing phase 3 study.
Marcinow AM, Hall N, Byrum E, Teknos TN, Old MO, Agrawal A
JAMA Otolaryngol Head Neck Surg 2013 Sep;139(9):895-902. doi: 10.1001/jamaoto.2013.4239. PMID: 24051744Free PMC Article
Use of a coincidence gamma camera to detect primary tumor with 18fluoro-2-deoxy-glucose in cervical lymph node metastases from an unknown origin.
Périé S, Talbot JN, Monceaux G, Grahek D, Kerrou K, Montravers F, St Guily JL
Ann Otol Rhinol Laryngol 2000 Aug;109(8 Pt 1):755-60. doi: 10.1177/000348940010900810. PMID: 10961809
The significance of DNA flow cytometry in predicting survival and delayed clinical manifestation of occult lymph node metastasis to the untreated neck in patients with oral squamous cell carcinoma.
Hemmer J, Kraft K, Kreidler J
J Craniomaxillofac Surg 1998 Dec;26(6):405-10. doi: 10.1016/s1010-5182(98)80076-0. PMID: 10036659
Effectiveness of selective neck dissection for management of the clinically negative neck.
Pitman KT, Johnson JT, Myers EN
Arch Otolaryngol Head Neck Surg 1997 Sep;123(9):917-22. doi: 10.1001/archotol.1997.01900090023004. PMID: 9305240

Prognosis

Sentinel node biopsy using indocyanine green in oral/oropharyngeal cancer.
Peng H, Wang SJ, Niu X, Yang X, Chi C, Zhang G
World J Surg Oncol 2015 Sep 17;13:278. doi: 10.1186/s12957-015-0691-6. PMID: 26381239Free PMC Article
Unilateral, clinically T2N0, squamous cell carcinoma of the tongue: surgical outcome analysis.
Lim YC, Choi EC
Int J Oral Maxillofac Surg 2007 Jul;36(7):610-4. Epub 2007 Mar 6 doi: 10.1016/j.ijom.2007.01.009. PMID: 17344023
Relevance of skip metastases for squamous cell carcinoma of the oral tongue and the floor of the mouth.
Dias FL, Lima RA, Kligerman J, Farias TP, Soares JR, Manfro G, Sa GM
Otolaryngol Head Neck Surg 2006 Mar;134(3):460-5. doi: 10.1016/j.otohns.2005.09.025. PMID: 16500445
Surgical treatment of squamous cell carcinoma of the base of tongue.
Gourin CG, Johnson JT
Head Neck 2001 Aug;23(8):653-60. doi: 10.1002/hed.1092. PMID: 11443748
The significance of DNA flow cytometry in predicting survival and delayed clinical manifestation of occult lymph node metastasis to the untreated neck in patients with oral squamous cell carcinoma.
Hemmer J, Kraft K, Kreidler J
J Craniomaxillofac Surg 1998 Dec;26(6):405-10. doi: 10.1016/s1010-5182(98)80076-0. PMID: 10036659

Clinical prediction guides

Use of a novel receptor-targeted (CD206) radiotracer, 99mTc-tilmanocept, and SPECT/CT for sentinel lymph node detection in oral cavity squamous cell carcinoma: initial institutional report in an ongoing phase 3 study.
Marcinow AM, Hall N, Byrum E, Teknos TN, Old MO, Agrawal A
JAMA Otolaryngol Head Neck Surg 2013 Sep;139(9):895-902. doi: 10.1001/jamaoto.2013.4239. PMID: 24051744Free PMC Article
Unilateral, clinically T2N0, squamous cell carcinoma of the tongue: surgical outcome analysis.
Lim YC, Choi EC
Int J Oral Maxillofac Surg 2007 Jul;36(7):610-4. Epub 2007 Mar 6 doi: 10.1016/j.ijom.2007.01.009. PMID: 17344023
Relevance of skip metastases for squamous cell carcinoma of the oral tongue and the floor of the mouth.
Dias FL, Lima RA, Kligerman J, Farias TP, Soares JR, Manfro G, Sa GM
Otolaryngol Head Neck Surg 2006 Mar;134(3):460-5. doi: 10.1016/j.otohns.2005.09.025. PMID: 16500445
The significance of DNA flow cytometry in predicting survival and delayed clinical manifestation of occult lymph node metastasis to the untreated neck in patients with oral squamous cell carcinoma.
Hemmer J, Kraft K, Kreidler J
J Craniomaxillofac Surg 1998 Dec;26(6):405-10. doi: 10.1016/s1010-5182(98)80076-0. PMID: 10036659
Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?
Byers RM, El-Naggar AK, Lee YY, Rao B, Fornage B, Terry NH, Sample D, Hankins P, Smith TL, Wolf PJ
Head Neck 1998 Mar;20(2):138-44. doi: 10.1002/(sici)1097-0347(199803)20:2<138::aid-hed7>3.0.co;2-3. PMID: 9484945

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...