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Untreated Hematopoietic and Lymphoid Cell Neoplasm

MedGen UID:
856812
•Concept ID:
C3897218
•
Finding

Definition

A finding of hematopoietic or lymphoid cell neoplasm that has not been treated. [from NCI]

Professional guidelines

PubMed

Bortezomib for the Treatment of Hematologic Malignancies: 15 Years Later.
Robak P, Robak T
Drugs R D 2019 Jun;19(2):73-92. doi: 10.1007/s40268-019-0269-9. PMID: 30993606Free PMC Article
Diagnosis and treatment of thrombocythemia in myeloproliferative disorders.
Gilbert HS
Oncology (Williston Park) 2001 Aug;15(8):989-96, 998; discussion 999-1000,1006,1008. PMID: 11548978
Diagnosis and treatment of polycythemia vera and possible future study designs of the PVSG.
Michiels JJ, Barbui T, Finazzi G, Fuchtman SM, Kutti J, Rain JD, Silver RT, Tefferi A, Thiele J
Leuk Lymphoma 2000 Jan;36(3-4):239-53. doi: 10.3109/10428190009148845. PMID: 10674896

Recent clinical studies

Etiology

Role of stem cell transplant in CD30+ PTCL following frontline brentuximab vedotin plus CHP or CHOP in ECHELON-2.
Savage KJ, Horwitz SM, Advani R, Christensen JH, Domingo-Domenech E, Rossi G, Morschhauser F, Alpdogan O, Suh C, Tobinai K, Shustov A, Trneny M, Yuen S, Zinzani PL, Trümper L, Ilidge T, O'Connor OA, Pro B, Miao H, Bunn V, Fenton K, Fanale M, Puhlmann M, Iyer S
Blood Adv 2022 Oct 11;6(19):5550-5555. doi: 10.1182/bloodadvances.2020003971. PMID: 35470385Free PMC Article
Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study.
Hosomi Y, Morita S, Sugawara S, Kato T, Fukuhara T, Gemma A, Takahashi K, Fujita Y, Harada T, Minato K, Takamura K, Hagiwara K, Kobayashi K, Nukiwa T, Inoue A; North-East Japan Study Group
J Clin Oncol 2020 Jan 10;38(2):115-123. Epub 2019 Nov 4 doi: 10.1200/JCO.19.01488. PMID: 31682542
Total Neoadjuvant Therapy With FOLFIRINOX Followed by Individualized Chemoradiotherapy for Borderline Resectable Pancreatic Adenocarcinoma: A Phase 2 Clinical Trial.
Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernández-Del Castillo C, Ferrone CR, Hong TS
JAMA Oncol 2018 Jul 1;4(7):963-969. doi: 10.1001/jamaoncol.2018.0329. PMID: 29800971Free PMC Article
Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma.
Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Illés Á, Picardi M, Lech-Maranda E, Oki Y, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Chen R, Ramchandren R, Zinzani PL, Cunningham D, Rosta A, Josephson NC, Song E, Sachs J, Liu R, Jolin HA, Huebner D, Radford J; ECHELON-1 Study Group
N Engl J Med 2018 Jan 25;378(4):331-344. Epub 2017 Dec 10 doi: 10.1056/NEJMoa1708984. PMID: 29224502Free PMC Article
Proteinuria and hematuria in the neonate.
Joseph C, Gattineni J
Curr Opin Pediatr 2016 Apr;28(2):202-8. doi: 10.1097/MOP.0000000000000323. PMID: 26845146Free PMC Article

Diagnosis

Single-cell technologies and analyses in hematopoiesis and hematological malignancies.
Campillo-Marcos I, Alvarez-Errico D, Alandes RA, Mereu E, Esteller M
Exp Hematol 2021 Jun;98:1-13. Epub 2021 May 9 doi: 10.1016/j.exphem.2021.05.001. PMID: 33979683
Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study.
Hosomi Y, Morita S, Sugawara S, Kato T, Fukuhara T, Gemma A, Takahashi K, Fujita Y, Harada T, Minato K, Takamura K, Hagiwara K, Kobayashi K, Nukiwa T, Inoue A; North-East Japan Study Group
J Clin Oncol 2020 Jan 10;38(2):115-123. Epub 2019 Nov 4 doi: 10.1200/JCO.19.01488. PMID: 31682542
Total Neoadjuvant Therapy With FOLFIRINOX Followed by Individualized Chemoradiotherapy for Borderline Resectable Pancreatic Adenocarcinoma: A Phase 2 Clinical Trial.
Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernández-Del Castillo C, Ferrone CR, Hong TS
JAMA Oncol 2018 Jul 1;4(7):963-969. doi: 10.1001/jamaoncol.2018.0329. PMID: 29800971Free PMC Article
Proteinuria and hematuria in the neonate.
Joseph C, Gattineni J
Curr Opin Pediatr 2016 Apr;28(2):202-8. doi: 10.1097/MOP.0000000000000323. PMID: 26845146Free PMC Article
Polycythemia vera.
Stuart BJ, Viera AJ
Am Fam Physician 2004 May 1;69(9):2139-44. PMID: 15152961

Therapy

Role of stem cell transplant in CD30+ PTCL following frontline brentuximab vedotin plus CHP or CHOP in ECHELON-2.
Savage KJ, Horwitz SM, Advani R, Christensen JH, Domingo-Domenech E, Rossi G, Morschhauser F, Alpdogan O, Suh C, Tobinai K, Shustov A, Trneny M, Yuen S, Zinzani PL, Trümper L, Ilidge T, O'Connor OA, Pro B, Miao H, Bunn V, Fenton K, Fanale M, Puhlmann M, Iyer S
Blood Adv 2022 Oct 11;6(19):5550-5555. doi: 10.1182/bloodadvances.2020003971. PMID: 35470385Free PMC Article
Final Overall Survival and Molecular Analysis in IMmotion151, a Phase 3 Trial Comparing Atezolizumab Plus Bevacizumab vs Sunitinib in Patients With Previously Untreated Metastatic Renal Cell Carcinoma.
Motzer RJ, Powles T, Atkins MB, Escudier B, McDermott DF, Alekseev BY, Lee JL, Suarez C, Stroyakovskiy D, De Giorgi U, Donskov F, Mellado B, Banchereau R, Hamidi H, Khan O, Craine V, Huseni M, Flinn N, Dubey S, Rini BI
JAMA Oncol 2022 Feb 1;8(2):275-280. doi: 10.1001/jamaoncol.2021.5981. PMID: 34940781Free PMC Article
Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study.
Hosomi Y, Morita S, Sugawara S, Kato T, Fukuhara T, Gemma A, Takahashi K, Fujita Y, Harada T, Minato K, Takamura K, Hagiwara K, Kobayashi K, Nukiwa T, Inoue A; North-East Japan Study Group
J Clin Oncol 2020 Jan 10;38(2):115-123. Epub 2019 Nov 4 doi: 10.1200/JCO.19.01488. PMID: 31682542
Total Neoadjuvant Therapy With FOLFIRINOX Followed by Individualized Chemoradiotherapy for Borderline Resectable Pancreatic Adenocarcinoma: A Phase 2 Clinical Trial.
Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernández-Del Castillo C, Ferrone CR, Hong TS
JAMA Oncol 2018 Jul 1;4(7):963-969. doi: 10.1001/jamaoncol.2018.0329. PMID: 29800971Free PMC Article
Cabozantinib Versus Sunitinib As Initial Targeted Therapy for Patients With Metastatic Renal Cell Carcinoma of Poor or Intermediate Risk: The Alliance A031203 CABOSUN Trial.
Choueiri TK, Halabi S, Sanford BL, Hahn O, Michaelson MD, Walsh MK, Feldman DR, Olencki T, Picus J, Small EJ, Dakhil S, George DJ, Morris MJ
J Clin Oncol 2017 Feb 20;35(6):591-597. Epub 2016 Nov 14 doi: 10.1200/JCO.2016.70.7398. PMID: 28199818Free PMC Article

Prognosis

Single-cell technologies and analyses in hematopoiesis and hematological malignancies.
Campillo-Marcos I, Alvarez-Errico D, Alandes RA, Mereu E, Esteller M
Exp Hematol 2021 Jun;98:1-13. Epub 2021 May 9 doi: 10.1016/j.exphem.2021.05.001. PMID: 33979683
Secondary esophageal squamous cell carcinoma after hematopoietic stem cell transplantation.
Nomura K, Iizuka T, Kaji D, Asano-Mori Y, Ochiai Y, Suzuki Y, Hayasaka J, Yamashita S, Matsui A, Kikuchi D, Taniguchi S, Takazawa Y, Hoteya S
J Cancer Res Clin Oncol 2021 Jul;147(7):2137-2144. Epub 2021 Jan 2 doi: 10.1007/s00432-020-03500-7. PMID: 33387042
Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study.
Hosomi Y, Morita S, Sugawara S, Kato T, Fukuhara T, Gemma A, Takahashi K, Fujita Y, Harada T, Minato K, Takamura K, Hagiwara K, Kobayashi K, Nukiwa T, Inoue A; North-East Japan Study Group
J Clin Oncol 2020 Jan 10;38(2):115-123. Epub 2019 Nov 4 doi: 10.1200/JCO.19.01488. PMID: 31682542
Total Neoadjuvant Therapy With FOLFIRINOX Followed by Individualized Chemoradiotherapy for Borderline Resectable Pancreatic Adenocarcinoma: A Phase 2 Clinical Trial.
Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernández-Del Castillo C, Ferrone CR, Hong TS
JAMA Oncol 2018 Jul 1;4(7):963-969. doi: 10.1001/jamaoncol.2018.0329. PMID: 29800971Free PMC Article
Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma.
Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Illés Á, Picardi M, Lech-Maranda E, Oki Y, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Chen R, Ramchandren R, Zinzani PL, Cunningham D, Rosta A, Josephson NC, Song E, Sachs J, Liu R, Jolin HA, Huebner D, Radford J; ECHELON-1 Study Group
N Engl J Med 2018 Jan 25;378(4):331-344. Epub 2017 Dec 10 doi: 10.1056/NEJMoa1708984. PMID: 29224502Free PMC Article

Clinical prediction guides

Final Overall Survival and Molecular Analysis in IMmotion151, a Phase 3 Trial Comparing Atezolizumab Plus Bevacizumab vs Sunitinib in Patients With Previously Untreated Metastatic Renal Cell Carcinoma.
Motzer RJ, Powles T, Atkins MB, Escudier B, McDermott DF, Alekseev BY, Lee JL, Suarez C, Stroyakovskiy D, De Giorgi U, Donskov F, Mellado B, Banchereau R, Hamidi H, Khan O, Craine V, Huseni M, Flinn N, Dubey S, Rini BI
JAMA Oncol 2022 Feb 1;8(2):275-280. doi: 10.1001/jamaoncol.2021.5981. PMID: 34940781Free PMC Article
Clinical and Pathological Features of Renal Presentations in Polycythemia Vera.
Yang J, Yu X, Hu N, Su T
Am J Med Sci 2022 Jan;363(1):33-41. Epub 2021 Oct 21 doi: 10.1016/j.amjms.2021.10.009. PMID: 34687616
Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study.
Hosomi Y, Morita S, Sugawara S, Kato T, Fukuhara T, Gemma A, Takahashi K, Fujita Y, Harada T, Minato K, Takamura K, Hagiwara K, Kobayashi K, Nukiwa T, Inoue A; North-East Japan Study Group
J Clin Oncol 2020 Jan 10;38(2):115-123. Epub 2019 Nov 4 doi: 10.1200/JCO.19.01488. PMID: 31682542
Bendamustine: mechanism of action and clinical data.
Cheson BD, Leoni L
Clin Adv Hematol Oncol 2011 Aug;9(8 Suppl 19):1-11. PMID: 22362008
Farnesyltransferase inhibitors: where are we now?
Tsimberidou AM, Chandhasin C, Kurzrock R
Expert Opin Investig Drugs 2010 Dec;19(12):1569-80. Epub 2010 Nov 18 doi: 10.1517/13543784.2010.535516. PMID: 21083522

Recent systematic reviews

What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis.
Bronte G, Rolfo C, Passiglia F, Rizzo S, Gil-Bazo I, Fiorentino E, Cajozzo M, Van Meerbeeck JP, Lequaglie C, Santini D, Pauwels P, Russo A
Crit Rev Oncol Hematol 2015 Sep;95(3):306-17. Epub 2015 Apr 11 doi: 10.1016/j.critrevonc.2015.03.010. PMID: 25922216
Recombinant human erythropoietin and overall survival in cancer patients: results of a comprehensive meta-analysis.
Bohlius J, Langensiepen S, Schwarzer G, Seidenfeld J, Piper M, Bennett C, Engert A
J Natl Cancer Inst 2005 Apr 6;97(7):489-98. doi: 10.1093/jnci/dji087. PMID: 15812074

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