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New or Worsening Symptom

MedGen UID:: 857733
•Concept ID:: C3898139
•: Sign or Symptom

Definition

The subjective evidence of disease perceived by the patient that can be classified as new or worsening [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNew or Worsening Symptom

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Sign or Symptom
    - Symptom
      - New or Worsening Symptom

Professional guidelines

PubMed

American Association of Clinical Endocrinology Consensus Statement: Comprehensive Type 2 Diabetes Management Algorithm - 2023 Update.

Samson SL, Vellanki P, Blonde L, Christofides EA, Galindo RJ, Hirsch IB, Isaacs SD, Izuora KE, Low Wang CC, Twining CL, Umpierrez GE, Valencia WM
Endocr Pract 2023 May;29(5):305-340. doi: 10.1016/j.eprac.2023.02.001. PMID: 37150579

Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases.

Garcia-Pavia P, Rapezzi C, Adler Y, Arad M, Basso C, Brucato A, Burazor I, Caforio ALP, Damy T, Eriksson U, Fontana M, Gillmore JD, Gonzalez-Lopez E, Grogan M, Heymans S, Imazio M, Kindermann I, Kristen AV, Maurer MS, Merlini G, Pantazis A, Pankuweit S, Rigopoulos AG, Linhart A
Eur Heart J 2021 Apr 21;42(16):1554-1568. doi: 10.1093/eurheartj/ehab072. PMID: 33825853 Free PMC Article

Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents.

Wolraich ML, Hagan JF Jr, Allan C, Chan E, Davison D, Earls M, Evans SW, Flinn SK, Froehlich T, Frost J, Holbrook JR, Lehmann CU, Lessin HR, Okechukwu K, Pierce KL, Winner JD, Zurhellen W; SUBCOMMITTEE ON CHILDREN AND ADOLESCENTS WITH ATTENTION-DEFICIT/HYPERACTIVE DISORDER
Pediatrics 2019 Oct;144(4) doi: 10.1542/peds.2019-2528. PMID: 31570648 Free PMC Article

See all (143821)

Recent clinical studies

Etiology

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload.

Mullens W, Dauw J, Martens P, Verbrugge FH, Nijst P, Meekers E, Tartaglia K, Chenot F, Moubayed S, Dierckx R, Blouard P, Troisfontaines P, Derthoo D, Smolders W, Bruckers L, Droogne W, Ter Maaten JM, Damman K, Lassus J, Mebazaa A, Filippatos G, Ruschitzka F, Dupont M; ADVOR Study Group
N Engl J Med 2022 Sep 29;387(13):1185-1195. Epub 2022 Aug 27 doi: 10.1056/NEJMoa2203094. PMID: 36027559

Gout.

Dalbeth N, Gosling AL, Gaffo A, Abhishek A
Lancet 2021 May 15;397(10287):1843-1855. Epub 2021 Mar 30 doi: 10.1016/S0140-6736(21)00569-9. PMID: 33798500

2020 American College of Rheumatology Guideline for the Management of Gout.

FitzGerald JD, Dalbeth N, Mikuls T, Brignardello-Petersen R, Guyatt G, Abeles AM, Gelber AC, Harrold LR, Khanna D, King C, Levy G, Libbey C, Mount D, Pillinger MH, Rosenthal A, Singh JA, Sims JE, Smith BJ, Wenger NS, Bae SS, Danve A, Khanna PP, Kim SC, Lenert A, Poon S, Qasim A, Sehra ST, Sharma TSK, Toprover M, Turgunbaev M, Zeng L, Zhang MA, Turner AS, Neogi T
Arthritis Care Res (Hoboken) 2020 Jun;72(6):744-760. Epub 2020 May 11 doi: 10.1002/acr.24180. PMID: 32391934 Free PMC Article

Stress and psoriasis.

Rousset L, Halioua B
Int J Dermatol 2018 Oct;57(10):1165-1172. Epub 2018 May 4 doi: 10.1111/ijd.14032. PMID: 29729012

Acute exacerbation of COPD.

Ko FW, Chan KP, Hui DS, Goddard JR, Shaw JG, Reid DW, Yang IA
Respirology 2016 Oct;21(7):1152-65. Epub 2016 Mar 30 doi: 10.1111/resp.12780. PMID: 27028990 Free PMC Article

See all (850856)

Diagnosis

Asthma-COPD Overlap: What Are the Important Questions?

Leung C, Sin DD
Chest 2022 Feb;161(2):330-344. Epub 2021 Oct 6 doi: 10.1016/j.chest.2021.09.036. PMID: 34626594

Gout.

Dalbeth N, Gosling AL, Gaffo A, Abhishek A
Lancet 2021 May 15;397(10287):1843-1855. Epub 2021 Mar 30 doi: 10.1016/S0140-6736(21)00569-9. PMID: 33798500

Lupus Nephritis and Pregnancy: Concerns and Management.

Lightstone L, Hladunewich MA
Semin Nephrol 2017 Jul;37(4):347-353. doi: 10.1016/j.semnephrol.2017.05.006. PMID: 28711073

Management of Gout and Hyperuricemia in CKD.

Vargas-Santos AB, Neogi T
Am J Kidney Dis 2017 Sep;70(3):422-439. Epub 2017 Apr 26 doi: 10.1053/j.ajkd.2017.01.055. PMID: 28456346 Free PMC Article

Acute exacerbation of COPD.

Ko FW, Chan KP, Hui DS, Goddard JR, Shaw JG, Reid DW, Yang IA
Respirology 2016 Oct;21(7):1152-65. Epub 2016 Mar 30 doi: 10.1111/resp.12780. PMID: 27028990 Free PMC Article

See all (606763)

Therapy

Environmental Triggers of Hyperuricemia and Gout.

Helget LN, Mikuls TR
Rheum Dis Clin North Am 2022 Nov;48(4):891-906. doi: 10.1016/j.rdc.2022.06.009. PMID: 36333002 Free PMC Article

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload.

Update on gout management: what is old and what is new.

Afinogenova Y, Danve A, Neogi T
Curr Opin Rheumatol 2022 Mar 1;34(2):118-124. doi: 10.1097/BOR.0000000000000861. PMID: 34907116 Free PMC Article

Gout.

Dalbeth N, Gosling AL, Gaffo A, Abhishek A
Lancet 2021 May 15;397(10287):1843-1855. Epub 2021 Mar 30 doi: 10.1016/S0140-6736(21)00569-9. PMID: 33798500

2020 American College of Rheumatology Guideline for the Management of Gout.

See all (642260)

Prognosis

Pregnancy in patients with systemic lupus erythematosus: a systematic review.

Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558

Clinical Course and Characteristics of Generalized Pustular Psoriasis.

Choon SE, Navarini AA, Pinter A
Am J Clin Dermatol 2022 Jan;23(Suppl 1):21-29. Epub 2022 Jan 21 doi: 10.1007/s40257-021-00654-z. PMID: 35061227 Free PMC Article

Clinical disease activity and flare in SLE: Current concepts and novel biomarkers.

Thanou A, Jupe E, Purushothaman M, Niewold TB, Munroe ME
J Autoimmun 2021 May;119:102615. Epub 2021 Feb 22 doi: 10.1016/j.jaut.2021.102615. PMID: 33631651 Free PMC Article

Lupus Nephritis and Pregnancy: Concerns and Management.

Lightstone L, Hladunewich MA
Semin Nephrol 2017 Jul;37(4):347-353. doi: 10.1016/j.semnephrol.2017.05.006. PMID: 28711073

Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F
Int J Cancer 2015 Mar 1;136(5):E359-86. Epub 2014 Oct 9 doi: 10.1002/ijc.29210. PMID: 25220842

See all (466725)

Clinical prediction guides

Pregnancy in patients with systemic lupus erythematosus: a systematic review.

Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558

Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout.

Cipolletta E, Tata LJ, Nakafero G, Avery AJ, Mamas MA, Abhishek A
JAMA 2022 Aug 2;328(5):440-450. doi: 10.1001/jama.2022.11390. PMID: 35916846 Free PMC Article

A secondary analysis of the Belimumab International Study in Lupus Nephritis trial examined effects of belimumab on kidney outcomes and preservation of kidney function in patients with lupus nephritis.

Rovin BH, Furie R, Teng YKO, Contreras G, Malvar A, Yu X, Ji B, Green Y, Gonzalez-Rivera T, Bass D, Gilbride J, Tang CH, Roth DA
Kidney Int 2022 Feb;101(2):403-413. Epub 2021 Sep 22 doi: 10.1016/j.kint.2021.08.027. PMID: 34560137

Clinical disease activity and flare in SLE: Current concepts and novel biomarkers.

Thanou A, Jupe E, Purushothaman M, Niewold TB, Munroe ME
J Autoimmun 2021 May;119:102615. Epub 2021 Feb 22 doi: 10.1016/j.jaut.2021.102615. PMID: 33631651 Free PMC Article

Lupus Nephritis and Pregnancy: Concerns and Management.

Lightstone L, Hladunewich MA
Semin Nephrol 2017 Jul;37(4):347-353. doi: 10.1016/j.semnephrol.2017.05.006. PMID: 28711073

See all (581431)

Recent systematic reviews

Autism spectrum disorder and schizophrenia: An updated conceptual review.

Jutla A, Foss-Feig J, Veenstra-VanderWeele J
Autism Res 2022 Mar;15(3):384-412. Epub 2021 Dec 29 doi: 10.1002/aur.2659. PMID: 34967130 Free PMC Article

New Antipsychotic Medications in the Last Decade.

Pahwa M, Sleem A, Elsayed OH, Good ME, El-Mallakh RS
Curr Psychiatry Rep 2021 Nov 29;23(12):87. doi: 10.1007/s11920-021-01298-w. PMID: 34843030

Easy guide to conducting a systematic review.

Caldwell PH, Bennett T
J Paediatr Child Health 2020 Jun;56(6):853-856. Epub 2020 May 4 doi: 10.1111/jpc.14853. PMID: 32364273

2016 updated EULAR evidence-based recommendations for the management of gout.

Richette P, Doherty M, Pascual E, Barskova V, Becce F, Castañeda-Sanabria J, Coyfish M, Guillo S, Jansen TL, Janssens H, Lioté F, Mallen C, Nuki G, Perez-Ruiz F, Pimentao J, Punzi L, Pywell T, So A, Tausche AK, Uhlig T, Zavada J, Zhang W, Tubach F, Bardin T
Ann Rheum Dis 2017 Jan;76(1):29-42. Epub 2016 Jul 25 doi: 10.1136/annrheumdis-2016-209707. PMID: 27457514

A new taxonomy for describing and defining adherence to medications.

Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, Dobbels F, Fargher E, Morrison V, Lewek P, Matyjaszczyk M, Mshelia C, Clyne W, Aronson JK, Urquhart J; ABC Project Team
Br J Clin Pharmacol 2012 May;73(5):691-705. doi: 10.1111/j.1365-2125.2012.04167.x. PMID: 22486599 Free PMC Article

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MedGen

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New or Worsening Symptom

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity