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Neonatal Hypoxic Ischemic Encephalopathy

MedGen UID:
857741
Concept ID:
C3898147
Disease or Syndrome

Definition

Injury to the central nervous system in the newborn period that occurs when there is insufficient delivery of oxygen to all or part of the brain. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal Hypoxic Ischemic Encephalopathy

Professional guidelines

PubMed

Arnautovic T, Sinha S, Laptook AR
Obstet Gynecol 2024 Jan 1;143(1):67-81. Epub 2023 Oct 5 doi: 10.1097/AOG.0000000000005392. PMID: 37797337Free PMC Article
Schump EA
Crit Care Nurs Clin North Am 2018 Dec;30(4):509-521. doi: 10.1016/j.cnc.2018.07.007. PMID: 30447810
Yıldız EP, Ekici B, Tatlı B
Expert Rev Neurother 2017 May;17(5):449-459. Epub 2016 Nov 23 doi: 10.1080/14737175.2017.1259567. PMID: 27830959

Recent clinical studies

Etiology

Wu YW, Comstock BA, Gonzalez FF, Mayock DE, Goodman AM, Maitre NL, Chang T, Van Meurs KP, Lampland AL, Bendel-Stenzel E, Mathur AM, Wu TW, Riley D, Mietzsch U, Chalak L, Flibotte J, Weitkamp JH, Ahmad KA, Yanowitz TD, Baserga M, Poindexter BB, Rogers EE, Lowe JR, Kuban KCK, O'Shea TM, Wisnowski JL, McKinstry RC, Bluml S, Bonifacio S, Benninger KL, Rao R, Smyser CD, Sokol GM, Merhar S, Schreiber MD, Glass HC, Heagerty PJ, Juul SE; HEAL Consortium
N Engl J Med 2022 Jul 14;387(2):148-159. doi: 10.1056/NEJMoa2119660. PMID: 35830641Free PMC Article
Kicman A, Toczek M
Int J Mol Sci 2020 Sep 14;21(18) doi: 10.3390/ijms21186740. PMID: 32937917Free PMC Article
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551
Schump EA
Crit Care Nurs Clin North Am 2018 Dec;30(4):509-521. doi: 10.1016/j.cnc.2018.07.007. PMID: 30447810
Yıldız EP, Ekici B, Tatlı B
Expert Rev Neurother 2017 May;17(5):449-459. Epub 2016 Nov 23 doi: 10.1080/14737175.2017.1259567. PMID: 27830959

Diagnosis

Pedroza-García KA, Calderón-Vallejo D, Quintanar JL
Neuropediatrics 2022 Dec;53(6):402-417. Epub 2022 Aug 28 doi: 10.1055/s-0042-1755235. PMID: 36030792
Sánchez-Illana Á, Piñeiro-Ramos JD, Kuligowski J
Semin Fetal Neonatal Med 2020 Apr;25(2):101084. Epub 2020 Jan 16 doi: 10.1016/j.siny.2020.101084. PMID: 31983670
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551
Yıldız EP, Ekici B, Tatlı B
Expert Rev Neurother 2017 May;17(5):449-459. Epub 2016 Nov 23 doi: 10.1080/14737175.2017.1259567. PMID: 27830959
Lv H, Wang Q, Wu S, Yang L, Ren P, Yang Y, Gao J, Li L
Clin Chim Acta 2015 Oct 23;450:282-97. Epub 2015 Aug 28 doi: 10.1016/j.cca.2015.08.021. PMID: 26320853

Therapy

Wu YW, Comstock BA, Gonzalez FF, Mayock DE, Goodman AM, Maitre NL, Chang T, Van Meurs KP, Lampland AL, Bendel-Stenzel E, Mathur AM, Wu TW, Riley D, Mietzsch U, Chalak L, Flibotte J, Weitkamp JH, Ahmad KA, Yanowitz TD, Baserga M, Poindexter BB, Rogers EE, Lowe JR, Kuban KCK, O'Shea TM, Wisnowski JL, McKinstry RC, Bluml S, Bonifacio S, Benninger KL, Rao R, Smyser CD, Sokol GM, Merhar S, Schreiber MD, Glass HC, Heagerty PJ, Juul SE; HEAL Consortium
N Engl J Med 2022 Jul 14;387(2):148-159. doi: 10.1056/NEJMoa2119660. PMID: 35830641Free PMC Article
Victor S, Rocha-Ferreira E, Rahim A, Hagberg H, Edwards D
Eur J Pediatr 2022 Mar;181(3):875-887. Epub 2021 Nov 24 doi: 10.1007/s00431-021-04320-8. PMID: 34820702Free PMC Article
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551
Yıldız EP, Ekici B, Tatlı B
Expert Rev Neurother 2017 May;17(5):449-459. Epub 2016 Nov 23 doi: 10.1080/14737175.2017.1259567. PMID: 27830959
Natarajan G, Pappas A, Shankaran S
Semin Perinatol 2016 Dec;40(8):549-555. Epub 2016 Nov 15 doi: 10.1053/j.semperi.2016.09.007. PMID: 27863707Free PMC Article

Prognosis

Arnautovic T, Sinha S, Laptook AR
Obstet Gynecol 2024 Jan 1;143(1):67-81. Epub 2023 Oct 5 doi: 10.1097/AOG.0000000000005392. PMID: 37797337Free PMC Article
Sánchez-Illana Á, Piñeiro-Ramos JD, Kuligowski J
Semin Fetal Neonatal Med 2020 Apr;25(2):101084. Epub 2020 Jan 16 doi: 10.1016/j.siny.2020.101084. PMID: 31983670
Natarajan G, Pappas A, Shankaran S
Semin Perinatol 2016 Dec;40(8):549-555. Epub 2016 Nov 15 doi: 10.1053/j.semperi.2016.09.007. PMID: 27863707Free PMC Article
Krishnan P, Shroff M
Indian J Pediatr 2016 Sep;83(9):995-1002. Epub 2016 Feb 24 doi: 10.1007/s12098-016-2042-1. PMID: 26909496
Lv H, Wang Q, Wu S, Yang L, Ren P, Yang Y, Gao J, Li L
Clin Chim Acta 2015 Oct 23;450:282-97. Epub 2015 Aug 28 doi: 10.1016/j.cca.2015.08.021. PMID: 26320853

Clinical prediction guides

Wu YW, Comstock BA, Gonzalez FF, Mayock DE, Goodman AM, Maitre NL, Chang T, Van Meurs KP, Lampland AL, Bendel-Stenzel E, Mathur AM, Wu TW, Riley D, Mietzsch U, Chalak L, Flibotte J, Weitkamp JH, Ahmad KA, Yanowitz TD, Baserga M, Poindexter BB, Rogers EE, Lowe JR, Kuban KCK, O'Shea TM, Wisnowski JL, McKinstry RC, Bluml S, Bonifacio S, Benninger KL, Rao R, Smyser CD, Sokol GM, Merhar S, Schreiber MD, Glass HC, Heagerty PJ, Juul SE; HEAL Consortium
N Engl J Med 2022 Jul 14;387(2):148-159. doi: 10.1056/NEJMoa2119660. PMID: 35830641Free PMC Article
Kicman A, Toczek M
Int J Mol Sci 2020 Sep 14;21(18) doi: 10.3390/ijms21186740. PMID: 32937917Free PMC Article
Natarajan G, Pappas A, Shankaran S
Semin Perinatol 2016 Dec;40(8):549-555. Epub 2016 Nov 15 doi: 10.1053/j.semperi.2016.09.007. PMID: 27863707Free PMC Article
Krishnan P, Shroff M
Indian J Pediatr 2016 Sep;83(9):995-1002. Epub 2016 Feb 24 doi: 10.1007/s12098-016-2042-1. PMID: 26909496
Lv H, Wang Q, Wu S, Yang L, Ren P, Yang Y, Gao J, Li L
Clin Chim Acta 2015 Oct 23;450:282-97. Epub 2015 Aug 28 doi: 10.1016/j.cca.2015.08.021. PMID: 26320853

Recent systematic reviews

Serrenho I, Rosado M, Dinis A, M Cardoso C, Grãos M, Manadas B, Baltazar G
Int J Mol Sci 2021 Mar 19;22(6) doi: 10.3390/ijms22063142. PMID: 33808671Free PMC Article
Archambault J, Moreira A, McDaniel D, Winter L, Sun L, Hornsby P
PLoS One 2017;12(12):e0189895. Epub 2017 Dec 19 doi: 10.1371/journal.pone.0189895. PMID: 29261798Free PMC Article
Tagin M, Shah PS, Lee KS
J Perinatol 2013 Sep;33(9):663-9. Epub 2013 Jun 6 doi: 10.1038/jp.2013.65. PMID: 23743671
Tagin MA, Woolcott CG, Vincer MJ, Whyte RK, Stinson DA
Arch Pediatr Adolesc Med 2012 Jun 1;166(6):558-66. doi: 10.1001/archpediatrics.2011.1772. PMID: 22312166
Shah PS, Ohlsson A, Perlman M
Arch Pediatr Adolesc Med 2007 Oct;161(10):951-8. doi: 10.1001/archpedi.161.10.951. PMID: 17909138

Supplemental Content

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