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Circumscribed Morphea

MedGen UID:
859215
•Concept ID:
C3899621
•
Disease or Syndrome

Definition

A type of morphea in which the lesions are circular or ovoid, and may be superficial or deep. The superficial lesions can have an indurated, waxy, ivory colored center with surrounding erythema or violaceous color during the active stage. Deep lesions can be sclerotic and depressed from underlying atrophy, and may show minimal skin color changes. When there are several (greater than or equal to 4), larger (greater than 3cm) lesions on two or more body areas this is classified as ""generalized morphea"". [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCircumscribed Morphea

Professional guidelines

PubMed

Drug Survival and Predictors of Drug Survival for Methotrexate Treatment in a Retrospective Cohort of Adult Patients with Localized Scleroderma.
Mertens JS, van den Reek JM, Kievit W, van de Kerkhof PC, Thurlings RM, Radstake TR, Seyger MM, de Jong EM
Acta Derm Venereol 2016 Nov 2;96(7):943-947. doi: 10.2340/00015555-2411. PMID: 26983450
Diagnosis and management of morphea and lichen sclerosus and atrophicus in children.
Pope E, Laxer RM
Pediatr Clin North Am 2014 Apr;61(2):309-19. Epub 2013 Dec 27 doi: 10.1016/j.pcl.2013.11.006. PMID: 24636648
Management of localized scleroderma.
Hunzelmann N, Scharffetter Kochanek K, Hager C, Krieg T
Semin Cutan Med Surg 1998 Mar;17(1):34-40. doi: 10.1016/s1085-5629(98)80060-6. PMID: 9512105

Recent clinical studies

Etiology

Connective tissue nevus misdiagnosed as juvenile localized scleroderma.
Tirelli F, Giraudo C, Soliani M, Calabrese F, Martini G, Gisondi P, Meneghel A, Zulian F
Pediatr Rheumatol Online J 2023 Oct 17;21(1):125. doi: 10.1186/s12969-023-00913-9. PMID: 37848914Free PMC Article
A retrospective study on clinical subtypes and management of morphea in 10 Italian Dermatological Units.
Virdi A, Patrizi A, Cambiaghi S, Diociaiuti A, El Hachem M, Schena D, Bassi A, Bonamonte D, Brazzelli V, Belloni Fortina A, Pepe P, DI Lernia V, Neri I
Ital J Dermatol Venerol 2021 Aug;156(4):446-454. Epub 2020 Oct 16 doi: 10.23736/S2784-8671.20.06632-8. PMID: 33070566
Interventions for morphea.
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article

Diagnosis

Connective tissue nevus misdiagnosed as juvenile localized scleroderma.
Tirelli F, Giraudo C, Soliani M, Calabrese F, Martini G, Gisondi P, Meneghel A, Zulian F
Pediatr Rheumatol Online J 2023 Oct 17;21(1):125. doi: 10.1186/s12969-023-00913-9. PMID: 37848914Free PMC Article
A retrospective study on clinical subtypes and management of morphea in 10 Italian Dermatological Units.
Virdi A, Patrizi A, Cambiaghi S, Diociaiuti A, El Hachem M, Schena D, Bassi A, Bonamonte D, Brazzelli V, Belloni Fortina A, Pepe P, DI Lernia V, Neri I
Ital J Dermatol Venerol 2021 Aug;156(4):446-454. Epub 2020 Oct 16 doi: 10.23736/S2784-8671.20.06632-8. PMID: 33070566
Interventions for morphea.
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article
Bee venom acupuncture for circumscribed morphea in a patient with systemic sclerosis: A case report.
Hwang JH, Kim KH
Medicine (Baltimore) 2018 Dec;97(49):e13404. doi: 10.1097/MD.0000000000013404. PMID: 30544415Free PMC Article

Therapy

Connective tissue nevus misdiagnosed as juvenile localized scleroderma.
Tirelli F, Giraudo C, Soliani M, Calabrese F, Martini G, Gisondi P, Meneghel A, Zulian F
Pediatr Rheumatol Online J 2023 Oct 17;21(1):125. doi: 10.1186/s12969-023-00913-9. PMID: 37848914Free PMC Article
A retrospective study on clinical subtypes and management of morphea in 10 Italian Dermatological Units.
Virdi A, Patrizi A, Cambiaghi S, Diociaiuti A, El Hachem M, Schena D, Bassi A, Bonamonte D, Brazzelli V, Belloni Fortina A, Pepe P, DI Lernia V, Neri I
Ital J Dermatol Venerol 2021 Aug;156(4):446-454. Epub 2020 Oct 16 doi: 10.23736/S2784-8671.20.06632-8. PMID: 33070566
Interventions for morphea.
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article
Bee venom acupuncture for circumscribed morphea in a patient with systemic sclerosis: A case report.
Hwang JH, Kim KH
Medicine (Baltimore) 2018 Dec;97(49):e13404. doi: 10.1097/MD.0000000000013404. PMID: 30544415Free PMC Article

Clinical prediction guides

A retrospective study on clinical subtypes and management of morphea in 10 Italian Dermatological Units.
Virdi A, Patrizi A, Cambiaghi S, Diociaiuti A, El Hachem M, Schena D, Bassi A, Bonamonte D, Brazzelli V, Belloni Fortina A, Pepe P, DI Lernia V, Neri I
Ital J Dermatol Venerol 2021 Aug;156(4):446-454. Epub 2020 Oct 16 doi: 10.23736/S2784-8671.20.06632-8. PMID: 33070566
Interventions for morphea.
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article

Recent systematic reviews

Interventions for morphea.
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article

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