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Chorionic Plate Vessel Thrombus

MedGen UID:
859225
•Concept ID:
C3899631
•
Finding

Definition

A focus of thrombus adhered to the wall of a fetal blood vessel in the chorionic plate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChorionic Plate Vessel Thrombus

Professional guidelines

PubMed

Placental histologic criteria for umbilical blood flow restriction in unexplained stillbirth.
Parast MM, Crum CP, Boyd TK
Hum Pathol 2008 Jun;39(6):948-53. Epub 2008 Apr 21 doi: 10.1016/j.humpath.2007.10.032. PMID: 18430456

Recent clinical studies

Etiology

Ferumoxytol-enhanced MR demonstration of changes to internal placental structure in placenta accreta spectrum: Preliminary findings.
Kliewer MA, Bockoven CG, Reeder SB, Bagley AR, Sadowski EA, Iruretagoyena JI, Beninati MJ, Fritsch MK
Placenta 2023 Mar 24;134:1-8. Epub 2023 Feb 10 doi: 10.1016/j.placenta.2023.02.003. PMID: 36807998
COVID-19 as an independent risk factor for subclinical placental dysfunction.
Jaiswal N, Puri M, Agarwal K, Singh S, Yadav R, Tiwary N, Tayal P, Vats B
Eur J Obstet Gynecol Reprod Biol 2021 Apr;259:7-11. Epub 2021 Jan 29 doi: 10.1016/j.ejogrb.2021.01.049. PMID: 33556768Free PMC Article
The correlation of morphological and thrombotic villous arterial lesions with fetal Doppler echocardiographic measurements in the placentas of low-risk term pregnancies.
Sekii K, Yaguchi C, Itoh H
Eur J Obstet Gynecol Reprod Biol 2018 Apr;223:39-45. Epub 2018 Feb 14 doi: 10.1016/j.ejogrb.2018.02.006. PMID: 29475119
Vasculitis as part of the fetal response to acute chorioamnionitis likely plays a role in the development of necrotizing enterocolitis and spontaneous intestinal perforation in premature neonates.
Ducey J, Owen A, Coombs R, Cohen M
Eur J Pediatr Surg 2015 Jun;25(3):284-91. Epub 2014 May 12 doi: 10.1055/s-0034-1373849. PMID: 24819242
Calcification of umbilical artery: two distinct lesions.
Khong TY, Dilly SA
J Clin Pathol 1989 Sep;42(9):931-4. doi: 10.1136/jcp.42.9.931. PMID: 2794081Free PMC Article

Diagnosis

Ferumoxytol-enhanced MR demonstration of changes to internal placental structure in placenta accreta spectrum: Preliminary findings.
Kliewer MA, Bockoven CG, Reeder SB, Bagley AR, Sadowski EA, Iruretagoyena JI, Beninati MJ, Fritsch MK
Placenta 2023 Mar 24;134:1-8. Epub 2023 Feb 10 doi: 10.1016/j.placenta.2023.02.003. PMID: 36807998
Placental Fetal Thrombotic Vasculopathy Occurring in Association with Megacystis-microcolon-intestinal Hypoperistalsis Syndrome: A Case Report.
Vélez-Pérez A, Younes P, Tatevian N
Ann Clin Lab Sci 2017 May;47(3):357-361. PMID: 28667041
Vasculitis as part of the fetal response to acute chorioamnionitis likely plays a role in the development of necrotizing enterocolitis and spontaneous intestinal perforation in premature neonates.
Ducey J, Owen A, Coombs R, Cohen M
Eur J Pediatr Surg 2015 Jun;25(3):284-91. Epub 2014 May 12 doi: 10.1055/s-0034-1373849. PMID: 24819242
First trimester maternal concentrations of thrombin-inhibitor complexes and the presence of histologic placental lesions at delivery.
Hackney DN, Chiao JP, Macpherson TA, Simhan HN
J Matern Fetal Neonatal Med 2009 Oct;22(10):837-42. doi: 10.1080/14767050902822211. PMID: 19658036
Placental histologic criteria for umbilical blood flow restriction in unexplained stillbirth.
Parast MM, Crum CP, Boyd TK
Hum Pathol 2008 Jun;39(6):948-53. Epub 2008 Apr 21 doi: 10.1016/j.humpath.2007.10.032. PMID: 18430456

Therapy

Gross umbilical cord complications are associated with placental lesions of circulatory stasis and fetal hypoxia.
Chan JS, Baergen RN
Pediatr Dev Pathol 2012 Nov-Dec;15(6):487-94. Epub 2012 Sep 14 doi: 10.2350/12-06-1211-OA.1. PMID: 22978619
Morphological changes in the placenta and decidua after induction of abortion by extra-amniotic prostaglandin.
Fox H, Herd ME, Harilal KR
Histopathology 1978 Mar;2(2):145-51. doi: 10.1111/j.1365-2559.1978.tb01702.x. PMID: 669592

Prognosis

A Case Report of Fetal Thrombotic Vasculopathy in a COVID Placenta.
Mai B, Alrais M, Tchakarov A
Ann Clin Lab Sci 2021 Jul;51(4):570-572. PMID: 34452898
The correlation of morphological and thrombotic villous arterial lesions with fetal Doppler echocardiographic measurements in the placentas of low-risk term pregnancies.
Sekii K, Yaguchi C, Itoh H
Eur J Obstet Gynecol Reprod Biol 2018 Apr;223:39-45. Epub 2018 Feb 14 doi: 10.1016/j.ejogrb.2018.02.006. PMID: 29475119
Placental Fetal Thrombotic Vasculopathy Occurring in Association with Megacystis-microcolon-intestinal Hypoperistalsis Syndrome: A Case Report.
Vélez-Pérez A, Younes P, Tatevian N
Ann Clin Lab Sci 2017 May;47(3):357-361. PMID: 28667041
Placental histologic criteria for umbilical blood flow restriction in unexplained stillbirth.
Parast MM, Crum CP, Boyd TK
Hum Pathol 2008 Jun;39(6):948-53. Epub 2008 Apr 21 doi: 10.1016/j.humpath.2007.10.032. PMID: 18430456
Incidental finding of Zygomyceteslike hyphae in the placenta. A case report.
Kambham N, Heller DS, Weitzman I
J Reprod Med 1998 Mar;43(3):230-2. PMID: 9564653

Clinical prediction guides

The correlation of morphological and thrombotic villous arterial lesions with fetal Doppler echocardiographic measurements in the placentas of low-risk term pregnancies.
Sekii K, Yaguchi C, Itoh H
Eur J Obstet Gynecol Reprod Biol 2018 Apr;223:39-45. Epub 2018 Feb 14 doi: 10.1016/j.ejogrb.2018.02.006. PMID: 29475119
Histological characteristics of singleton placentas delivered before the 28th week of gestation.
Hecht JL, Allred EN, Kliman HJ, Zambrano E, Doss BJ, Husain A, Pflueger SM, Chang CH, Livasy CA, Roberts D, Bhan I, Ross DW, Senagore PK, Leviton A; Elgan Study Investigators
Pathology 2008 Jun;40(4):372-6. doi: 10.1080/00313020802035865. PMID: 18446627Free PMC Article
Umbilical cord stricture and overcoiling are common causes of fetal demise.
Peng HQ, Levitin-Smith M, Rochelson B, Kahn E
Pediatr Dev Pathol 2006 Jan-Feb;9(1):14-9. Epub 2006 Apr 4 doi: 10.2350/05-05-0051.1. PMID: 16808633
Incidental finding of Zygomyceteslike hyphae in the placenta. A case report.
Kambham N, Heller DS, Weitzman I
J Reprod Med 1998 Mar;43(3):230-2. PMID: 9564653

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