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Childhood Brain Oligodendroglioma

MedGen UID:
859268
•Concept ID:
C3899674
•
Neoplastic Process

Definition

An oligodendroglioma that arises from the brain and occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Brain Oligodendroglioma

Professional guidelines

PubMed

Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation.
Dodgshun AJ, SantaCruz N, Hwang J, Ramkissoon SH, Malkin H, Bergthold G, Manley P, Chi S, MacGregor D, Goumnerova L, Sullivan M, Ligon K, Beroukhim R, Herrington B, Kieran MW, Hansford JR, Bandopadhayay P
J Neurooncol 2016 Jun;128(2):293-302. Epub 2016 Mar 19 doi: 10.1007/s11060-016-2109-x. PMID: 26994902
The impact of technical adjuncts in the surgical management of cerebral hemispheric low-grade gliomas of childhood.
Berger MS
J Neurooncol 1996 May-Jun;28(2-3):129-55. doi: 10.1007/BF00250195. PMID: 8832458
Role of radiation therapy in the management of neoplasms of the central nervous system.
Mayer EG, Boone ML, Aristizabal SA
Adv Neurol 1976;15:201-20. PMID: 180777

Recent clinical studies

Etiology

Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article
Clinical and histopathological profile of dysembryoplastic neuroepithelial tumor: An experience from a tertiary care center.
Gupta P, Siraj F, Malik A, Shankar KB
J Cancer Res Ther 2021 Jul-Sep;17(4):912-916. doi: 10.4103/jcrt.JCRT_632_19. PMID: 34528541
Glioblastomas, astrocytomas and oligodendrogliomas linked to Lynch syndrome.
Therkildsen C, Ladelund S, Rambech E, Persson A, Petersen A, Nilbert M
Eur J Neurol 2015 Apr;22(4):717-24. Epub 2015 Jan 19 doi: 10.1111/ene.12647. PMID: 25648859
Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780
Malignant glioma: neuropathology and neurobiology.
Preusser M, Haberler C, Hainfellner JA
Wien Med Wochenschr 2006 Jun;156(11-12):332-7. doi: 10.1007/s10354-006-0304-7. PMID: 16944363

Diagnosis

Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article
Clinical and histopathological profile of dysembryoplastic neuroepithelial tumor: An experience from a tertiary care center.
Gupta P, Siraj F, Malik A, Shankar KB
J Cancer Res Ther 2021 Jul-Sep;17(4):912-916. doi: 10.4103/jcrt.JCRT_632_19. PMID: 34528541
Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780
Molecular genetics of gliomas.
Appin CL, Brat DJ
Cancer J 2014 Jan-Feb;20(1):66-72. doi: 10.1097/PPO.0000000000000020. PMID: 24445767
Malignant glioma: neuropathology and neurobiology.
Preusser M, Haberler C, Hainfellner JA
Wien Med Wochenschr 2006 Jun;156(11-12):332-7. doi: 10.1007/s10354-006-0304-7. PMID: 16944363

Therapy

Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis.
Manoharan N, Ajuyah P, Senapati A, Wong M, Mullins A, Rodriguez M, Doyle H, McCowage G, Lau LMS, Ekert PG, Ziegler DS
Acta Neuropathol Commun 2021 Sep 7;9(1):147. doi: 10.1186/s40478-021-01248-w. PMID: 34493325Free PMC Article
Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial.
Dubbink HJ, Atmodimedjo PN, Kros JM, French PJ, Sanson M, Idbaih A, Wesseling P, Enting R, Spliet W, Tijssen C, Dinjens WN, Gorlia T, van den Bent MJ
Neuro Oncol 2016 Mar;18(3):388-400. Epub 2015 Sep 9 doi: 10.1093/neuonc/nov182. PMID: 26354927Free PMC Article
Anaplastic oligodendroglioma after childhood acute lymphoblastic leukemia: chemotherapy and autologous peripheral blood stem cell transplantation.
Hah JO
J Pediatr Hematol Oncol 2008 Oct;30(10):764-7. doi: 10.1097/MPH.0b013e31817e4a55. PMID: 19011476
Disseminating anaplastic brainstem oligodendroglioma associated with allelic loss in the tumor suppressor candidate region D19S246 of chromosome 19 mimicking an inflammatory central nervous system disease in a 9-year-old boy.
Mittelbronn M, Wolff M, Bültmann E, Nägele T, Capper D, Beck R, Meyermann R, Beschorner R
Hum Pathol 2005 Jul;36(7):854-7. doi: 10.1016/j.humpath.2005.05.017. PMID: 16084959
Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma.
Massimino M, Gandola L, Luksch R, Spreafico F, Riva D, Solero C, Giangaspero F, Locatelli F, Podda M, Bozzi F, Pignoli E, Collini P, Cefalo G, Zecca M, Casanova M, Ferrari A, Terenziani M, Meazza C, Polastri D, Scaramuzza D, Ravagnani F, Fossati-Bellani F
Neuro Oncol 2005 Jan;7(1):41-8. doi: 10.1215/S1152851704000304. PMID: 15701281Free PMC Article

Prognosis

Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article
Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780
Molecular genetics of gliomas.
Appin CL, Brat DJ
Cancer J 2014 Jan-Feb;20(1):66-72. doi: 10.1097/PPO.0000000000000020. PMID: 24445767
Malignant glioma: neuropathology and neurobiology.
Preusser M, Haberler C, Hainfellner JA
Wien Med Wochenschr 2006 Jun;156(11-12):332-7. doi: 10.1007/s10354-006-0304-7. PMID: 16944363
Oligodendroglioma in childhood.
Wang KC, Chi JG, Cho BK
J Korean Med Sci 1993 Apr;8(2):110-6. doi: 10.3346/jkms.1993.8.2.110. PMID: 8397926Free PMC Article

Clinical prediction guides

Clinical and histopathological profile of dysembryoplastic neuroepithelial tumor: An experience from a tertiary care center.
Gupta P, Siraj F, Malik A, Shankar KB
J Cancer Res Ther 2021 Jul-Sep;17(4):912-916. doi: 10.4103/jcrt.JCRT_632_19. PMID: 34528541
Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780
Molecular genetics of gliomas.
Appin CL, Brat DJ
Cancer J 2014 Jan-Feb;20(1):66-72. doi: 10.1097/PPO.0000000000000020. PMID: 24445767
The applicability of Collins' Law to childhood brain tumors and its usefulness as a predictor of survival.
Brown WD, Tavaré CJ, Sobel EL, Gilles FH
Neurosurgery 1995 Jun;36(6):1093-6. doi: 10.1227/00006123-199506000-00004. PMID: 7643986
Oligodendroglioma in childhood.
Wang KC, Chi JG, Cho BK
J Korean Med Sci 1993 Apr;8(2):110-6. doi: 10.3346/jkms.1993.8.2.110. PMID: 8397926Free PMC Article

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