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Mirror movements 3(MRMV3)

MedGen UID:
863561
•Concept ID:
C4015124
•
Disease or Syndrome
Synonym: MRMV3
 
Gene (location): DNAL4 (22q13.1)
 
Monarch Initiative: MONDO:0014478
OMIM®: 616059

Definition

Any familial congenital mirror movements in which the cause of the disease is a mutation in the DNAL4 gene. [from MONDO]

Clinical features

From HPO
Situs inversus
MedGen UID:
1642262
•Concept ID:
C4551493
•
Congenital Abnormality
A left-right reversal (or "mirror reflection") of the anatomical location of the major thoracic and abdominal organs.
See: Feature record | Search on this feature
Bimanual synkinesia
MedGen UID:
473166
•Concept ID:
C0454455
•
Disease or Syndrome
Involuntary movements of one hand that accompany and mirror intentional movements of the opposite hand.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

Mirror Therapy for the Management of Phantom Limb Pain: A Single- Center Experience.
Chong DST, Pople M, Hardy TJ, Cowan A, Birchley D, Guy A, McCarthy R, Welchman SA
Ann Vasc Surg 2023 Sep;95:184-187. Epub 2023 Apr 17 doi: 10.1016/j.avsg.2023.03.033. PMID: 37075833
Effect of mirror therapy in the treatment of phantom limb pain in amputees: A systematic review of randomized placebo-controlled trials does not find any evidence of efficacy.
Guémann M, Olié E, Raquin L, Courtet P, Risch N
Eur J Pain 2023 Jan;27(1):3-13. Epub 2022 Sep 19 doi: 10.1002/ejp.2035. PMID: 36094758Free PMC Article
Neglect syndrome in post-stroke conditions: assessment and treatment (scoping review).
Tavaszi I, Nagy AS, Szabo G, Fazekas G
Int J Rehabil Res 2021 Mar 1;44(1):3-14. doi: 10.1097/MRR.0000000000000438. PMID: 32991354

Recent clinical studies

Etiology

Therapeutic Role of Additional Mirror Therapy on the Recovery of Upper Extremity Motor Function after Stroke: A Single-Blind, Randomized Controlled Trial.
Wen X, Li L, Li X, Zha H, Liu Z, Peng Y, Liu X, Liu H, Yang Q, Wang J
Neural Plast 2022;2022:8966920. Epub 2022 Dec 31 doi: 10.1155/2022/8966920. PMID: 36624743Free PMC Article
Effect and mechanism of mirror therapy on lower limb rehabilitation after ischemic stroke: A fMRI study.
Cui W, Huang L, Tian Y, Luo H, Chen S, Yang Y, Li Y, Fu J, Yu Q, Xu L
NeuroRehabilitation 2022;51(1):65-77. doi: 10.3233/NRE-210307. PMID: 35311718
Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-analysis.
Xie HM, Zhang KX, Wang S, Wang N, Wang N, Li X, Huang LP
Arch Phys Med Rehabil 2022 May;103(5):988-997. Epub 2021 Aug 28 doi: 10.1016/j.apmr.2021.07.810. PMID: 34461084
Effects of phantom exercises on pain, mobility, and quality of life among lower limb amputees; a randomized controlled trial.
Zaheer A, Malik AN, Masood T, Fatima S
BMC Neurol 2021 Oct 27;21(1):416. doi: 10.1186/s12883-021-02441-z. PMID: 34706654Free PMC Article
Mirror therapy for improving motor function after stroke.
Thieme H, Mehrholz J, Pohl M, Behrens J, Dohle C
Cochrane Database Syst Rev 2012 Mar 14;2012(3):CD008449. doi: 10.1002/14651858.CD008449.pub2. PMID: 22419334Free PMC Article

Diagnosis

Approach to the Patient with Gait Disturbance.
Tarolli CG, Lizarraga KJ
Semin Neurol 2021 Dec;41(6):717-730. Epub 2021 Nov 26 doi: 10.1055/s-0041-1726355. PMID: 34826874
Extracellular Vesicles in Glioblastoma: Role in Biological Processes and in Therapeutic Applications.
Giusti I, Di Francesco M, Dolo V
Curr Cancer Drug Targets 2017;17(3):221-235. doi: 10.2174/1568009616666160813182959. PMID: 27528364
Transition in endocrinology: induction of puberty.
Dunkel L, Quinton R
Eur J Endocrinol 2014 Jun;170(6):R229-39. Epub 2014 May 17 doi: 10.1530/EJE-13-0894. PMID: 24836550
New insights (and new interrogations) in perinatal arterial ischemic stroke.
Chabrier S, Husson B, Dinomais M, Landrieu P, Nguyen The Tich S
Thromb Res 2011 Jan;127(1):13-22. Epub 2010 Nov 4 doi: 10.1016/j.thromres.2010.10.003. PMID: 21055794
How does the brain create rhythms?
Szirmai I
Ideggyogy Sz 2010 Jan 30;63(1-2):13-23. PMID: 20420120

Therapy

Therapeutic Role of Additional Mirror Therapy on the Recovery of Upper Extremity Motor Function after Stroke: A Single-Blind, Randomized Controlled Trial.
Wen X, Li L, Li X, Zha H, Liu Z, Peng Y, Liu X, Liu H, Yang Q, Wang J
Neural Plast 2022;2022:8966920. Epub 2022 Dec 31 doi: 10.1155/2022/8966920. PMID: 36624743Free PMC Article
Mirror therapy for unilateral neglect after stroke: A systematic review.
Zhang Y, Xing Y, Li C, Hua Y, Hu J, Wang Y, Ya R, Meng Q, Bai Y
Eur J Neurol 2022 Jan;29(1):358-371. Epub 2021 Oct 5 doi: 10.1111/ene.15122. PMID: 34558762
Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-analysis.
Xie HM, Zhang KX, Wang S, Wang N, Wang N, Li X, Huang LP
Arch Phys Med Rehabil 2022 May;103(5):988-997. Epub 2021 Aug 28 doi: 10.1016/j.apmr.2021.07.810. PMID: 34461084
The effects of mirror therapy on pain and motor control of phantom limb in amputees: A systematic review.
Barbin J, Seetha V, Casillas JM, Paysant J, Pérennou D
Ann Phys Rehabil Med 2016 Sep;59(4):270-5. Epub 2016 May 30 doi: 10.1016/j.rehab.2016.04.001. PMID: 27256539
Mirror therapy for improving motor function after stroke.
Thieme H, Mehrholz J, Pohl M, Behrens J, Dohle C
Cochrane Database Syst Rev 2012 Mar 14;2012(3):CD008449. doi: 10.1002/14651858.CD008449.pub2. PMID: 22419334Free PMC Article

Prognosis

Mirror movements and brain pathology in children with unilateral cerebral palsy.
Kuo HC, Ferre CL, Chin KY, Friel KM, Gordon AM
Dev Med Child Neurol 2023 Feb;65(2):264-273. Epub 2022 Jun 24 doi: 10.1111/dmcn.15322. PMID: 35751166
Callosal agenesis and congenital mirror movements: outcomes associated with DCC mutations.
Spencer-Smith M, Knight JL, Lacaze E; Irc5 Consortium, Depienne C, Lockhart PJ, Richards LJ, Heron D, Leventer RJ, Robinson GA
Dev Med Child Neurol 2020 Jun;62(6):758-762. Epub 2020 Feb 14 doi: 10.1111/dmcn.14486. PMID: 32060908
Mirror Movements are Linked to Executive Control in Healthy and Brain-injured Adults.
Tisseyre J, Amarantini D, Chalard A, Marque P, Gasq D, Tallet J
Neuroscience 2018 May 21;379:246-256. Epub 2018 Mar 26 doi: 10.1016/j.neuroscience.2018.03.027. PMID: 29592842
New insights (and new interrogations) in perinatal arterial ischemic stroke.
Chabrier S, Husson B, Dinomais M, Landrieu P, Nguyen The Tich S
Thromb Res 2011 Jan;127(1):13-22. Epub 2010 Nov 4 doi: 10.1016/j.thromres.2010.10.003. PMID: 21055794
Self-perception and action in infancy.
Rochat P
Exp Brain Res 1998 Nov;123(1-2):102-9. doi: 10.1007/s002210050550. PMID: 9835398

Clinical prediction guides

Therapeutic Role of Additional Mirror Therapy on the Recovery of Upper Extremity Motor Function after Stroke: A Single-Blind, Randomized Controlled Trial.
Wen X, Li L, Li X, Zha H, Liu Z, Peng Y, Liu X, Liu H, Yang Q, Wang J
Neural Plast 2022;2022:8966920. Epub 2022 Dec 31 doi: 10.1155/2022/8966920. PMID: 36624743Free PMC Article
Efficacy of mirror therapy and virtual reality therapy in alleviating phantom limb pain: a meta-analysis and systematic review.
Rajendram C, Ken-Dror G, Han T, Sharma P
BMJ Mil Health 2022 Apr;168(2):173-177. Epub 2022 Jan 18 doi: 10.1136/bmjmilitary-2021-002018. PMID: 35042760
Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-analysis.
Xie HM, Zhang KX, Wang S, Wang N, Wang N, Li X, Huang LP
Arch Phys Med Rehabil 2022 May;103(5):988-997. Epub 2021 Aug 28 doi: 10.1016/j.apmr.2021.07.810. PMID: 34461084
Effects of phantom exercises on pain, mobility, and quality of life among lower limb amputees; a randomized controlled trial.
Zaheer A, Malik AN, Masood T, Fatima S
BMC Neurol 2021 Oct 27;21(1):416. doi: 10.1186/s12883-021-02441-z. PMID: 34706654Free PMC Article
Mirror therapy for improving motor function after stroke.
Thieme H, Mehrholz J, Pohl M, Behrens J, Dohle C
Cochrane Database Syst Rev 2012 Mar 14;2012(3):CD008449. doi: 10.1002/14651858.CD008449.pub2. PMID: 22419334Free PMC Article

Recent systematic reviews

Effect of mirror therapy in the treatment of phantom limb pain in amputees: A systematic review of randomized placebo-controlled trials does not find any evidence of efficacy.
Guémann M, Olié E, Raquin L, Courtet P, Risch N
Eur J Pain 2023 Jan;27(1):3-13. Epub 2022 Sep 19 doi: 10.1002/ejp.2035. PMID: 36094758Free PMC Article
Mirror therapy for unilateral neglect after stroke: A systematic review.
Zhang Y, Xing Y, Li C, Hua Y, Hu J, Wang Y, Ya R, Meng Q, Bai Y
Eur J Neurol 2022 Jan;29(1):358-371. Epub 2021 Oct 5 doi: 10.1111/ene.15122. PMID: 34558762
Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-analysis.
Xie HM, Zhang KX, Wang S, Wang N, Wang N, Li X, Huang LP
Arch Phys Med Rehabil 2022 May;103(5):988-997. Epub 2021 Aug 28 doi: 10.1016/j.apmr.2021.07.810. PMID: 34461084
The effects of mirror therapy on pain and motor control of phantom limb in amputees: A systematic review.
Barbin J, Seetha V, Casillas JM, Paysant J, Pérennou D
Ann Phys Rehabil Med 2016 Sep;59(4):270-5. Epub 2016 May 30 doi: 10.1016/j.rehab.2016.04.001. PMID: 27256539
Mirror therapy for improving motor function after stroke.
Thieme H, Mehrholz J, Pohl M, Behrens J, Dohle C
Cochrane Database Syst Rev 2012 Mar 14;2012(3):CD008449. doi: 10.1002/14651858.CD008449.pub2. PMID: 22419334Free PMC Article

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