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Abnormal circulating creatine concentration

MedGen UID:: 866482
•Concept ID:: C4020731
•: Finding

Synonyms:	Abnormality of creatine metabolism; Creatine metabolism abnormal

HPO:	HP:0012113

Definition

A deviation from the normal concentration of creatine in the blood circulation. Creatine is a derivative of glycine having methyl and amidino groups attached to the nitrogen. Creatine is naturally produced from amino acids, primarily in liver and kidney, and acts as an energy source for cells, primarly for muscle cells. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal circulating creatine concentration

Phenotypic abnormality
- Abnormality of metabolism/homeostasis
  - Abnormal circulating metabolite concentration
    - Abnormal circulating organic compound concentration
      - Abnormal circulating creatine concentration
        Elevated circulating creatine concentration
        Reduced circulating creatine concentration

Recent clinical studies

Etiology

Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity after Kidney Transplantation.

Lepping RJ, Montgomery RN, Sharma P, Mahnken JD, Vidoni ED, Choi IY, Sarnak MJ, Brooks WM, Burns JM, Gupta A
J Am Soc Nephrol 2021 Jan;32(1):177-187. Epub 2020 Oct 16 doi: 10.1681/ASN.2020050584. PMID: 33067382 Free PMC Article

Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.

Sughimoto K, Kohira S, Hayashi H, Torii S, Kitamura T, Horai T, Miyaji K
J Thorac Cardiovasc Surg 2018 Dec;156(6):2251-2257. Epub 2018 Sep 28 doi: 10.1016/j.jtcvs.2018.08.097. PMID: 30449581

Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes.

Scheuermann-Freestone M, Madsen PL, Manners D, Blamire AM, Buckingham RE, Styles P, Radda GK, Neubauer S, Clarke K
Circulation 2003 Jun 24;107(24):3040-6. Epub 2003 Jun 16 doi: 10.1161/01.CIR.0000072789.89096.10. PMID: 12810608

Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.

Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538

Circulating cardiac troponin T in myocardial contusion.

Ferjani M, Droc G, Dreux S, Arthaud M, Goarin JP, Riou B, Coriat P
Chest 1997 Feb;111(2):427-33. doi: 10.1378/chest.111.2.427. PMID: 9041992

See all (16)

Diagnosis

Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes.

Imaging and epilepsy.

Duncan JS
Brain 1997 Feb;120 ( Pt 2):339-77. doi: 10.1093/brain/120.2.339. PMID: 9117380

Circulating cardiac troponin T in myocardial contusion.

Ferjani M, Droc G, Dreux S, Arthaud M, Goarin JP, Riou B, Coriat P
Chest 1997 Feb;111(2):427-33. doi: 10.1378/chest.111.2.427. PMID: 9041992

Duchenne muscular dystrophy: pathogenetic aspects and genetic prevention.

Moser H
Hum Genet 1984;66(1):17-40. doi: 10.1007/BF00275183. PMID: 6365739

See all (15)

Therapy

Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity after Kidney Transplantation.

Resistance to thyroid hormone caused by a mutation in thyroid hormone receptor (TR)α1 and TRα2: clinical, biochemical, and genetic analyses of three related patients.

Moran C, Agostini M, Visser WE, Schoenmakers E, Schoenmakers N, Offiah AC, Poole K, Rajanayagam O, Lyons G, Halsall D, Gurnell M, Chrysis D, Efthymiadou A, Buchanan C, Aylwin S, Chatterjee KK
Lancet Diabetes Endocrinol 2014 Aug;2(8):619-26. Epub 2014 Jun 23 doi: 10.1016/S2213-8587(14)70111-1. PMID: 24969835 Free PMC Article

High-dose aprotinin does not affect troponin I, N-Terminal pro-B-type natriuretic peptid and renal function in children submitted to surgical correction with extracorporeal circulation.

Ferreira CA, Vicente WV, Evora PR, Rodrigues AJ, Klamt JG, Carlotti AP, Carmona F, Manso PH
Rev Bras Cir Cardiovasc 2009 Oct-Dec;24(4):519-32. doi: 10.1590/s0102-76382009000500014. PMID: 20305926

Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes.

Inflammatory myopathy, IgA deficiency, and intestinal malabsorption.

Carroll JE, Silverman A, Isobe Y, Brown WR, Kelts KA, Brooke MH
J Pediatr 1976 Aug;89(2):216-9. doi: 10.1016/s0022-3476(76)80451-9. PMID: 940014

See all (12)

Prognosis

Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.

Sughimoto K, Kohira S, Hayashi H, Torii S, Kitamura T, Horai T, Miyaji K
J Thorac Cardiovasc Surg 2018 Dec;156(6):2251-2257. Epub 2018 Sep 28 doi: 10.1016/j.jtcvs.2018.08.097. PMID: 30449581

Tumor necrosis factor system activity is associated with insulin resistance and dyslipidemia in myotonic dystrophy.

Fernández-Real JM, Molina A, Broch M, Ricart W, Gutiérrez C, Casamitjana R, Vendrell J, Soler J, Gómez-Sáez JM
Diabetes 1999 May;48(5):1108-12. doi: 10.2337/diabetes.48.5.1108. PMID: 10331417

Renal function and urate metabolism in late survivors with cyanotic congenital heart disease.

Ross EA, Perloff JK, Danovitch GM, Child JS, Canobbio MM
Circulation 1986 Mar;73(3):396-400. doi: 10.1161/01.cir.73.3.396. PMID: 3948350

Creatine kinase BB: a new tumor-associated marker.

Silverman LM, Dermer GB, Zweig MH, Van Steirteghem AC, Tökés ZA
Clin Chem 1979 Aug;25(8):1432-5. PMID: 455680

See all (11)

Clinical prediction guides

Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.

Sughimoto K, Kohira S, Hayashi H, Torii S, Kitamura T, Horai T, Miyaji K
J Thorac Cardiovasc Surg 2018 Dec;156(6):2251-2257. Epub 2018 Sep 28 doi: 10.1016/j.jtcvs.2018.08.097. PMID: 30449581

Tumor necrosis factor system activity is associated with insulin resistance and dyslipidemia in myotonic dystrophy.

Fernández-Real JM, Molina A, Broch M, Ricart W, Gutiérrez C, Casamitjana R, Vendrell J, Soler J, Gómez-Sáez JM
Diabetes 1999 May;48(5):1108-12. doi: 10.2337/diabetes.48.5.1108. PMID: 10331417

Renal function and urate metabolism in late survivors with cyanotic congenital heart disease.

Ross EA, Perloff JK, Danovitch GM, Child JS, Canobbio MM
Circulation 1986 Mar;73(3):396-400. doi: 10.1161/01.cir.73.3.396. PMID: 3948350

Duchenne muscular dystrophy: pathogenetic aspects and genetic prevention.

Moser H
Hum Genet 1984;66(1):17-40. doi: 10.1007/BF00275183. PMID: 6365739

See all (14)

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Abnormal circulating creatine concentration

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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