U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sclerosis of proximal finger phalanx

MedGen UID:
866592
•Concept ID:
C4020938
•
Anatomical Abnormality
Synonyms: Increased bone density in innermost finger bone; Sclerosis of the proximal phalanges of the hand
 
HPO: HP:0100917

Definition

An elevation in bone density in one or more proximal phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity. [from HPO]

Recent clinical studies

Etiology

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
In vivo study of skin mechanical properties in Raynaud's phenomenon.
Dobrev H
Skin Res Technol 2007 Feb;13(1):91-4. doi: 10.1111/j.1600-0846.2007.00197.x. PMID: 17250538
Radiographic changes in the hands and fingers of young, high-level climbers.
Schöffl V, Hochholzer T, Imhoff A
Am J Sports Med 2004 Oct-Nov;32(7):1688-94. doi: 10.1177/0363546503262805. PMID: 15494334

Diagnosis

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Reliability of ultrasound measurements of dermal thickness at digits in systemic sclerosis: role of elastosonography.
Di Geso L, Filippucci E, Girolimetti R, Tardella M, Gutierrez M, De Angelis R, Salaffi F, Grassi W
Clin Exp Rheumatol 2011 Nov-Dec;29(6):926-32. Epub 2011 Dec 22 PMID: 22032470
Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis.
Akesson A, Hesselstrand R, Scheja A, Wildt M
Ann Rheum Dis 2004 Jul;63(7):791-6. doi: 10.1136/ard.2003.012146. PMID: 15194573Free PMC Article
Comparison of high frequency (20 MHz) ultrasound and palpation for the assessment of skin involvement in systemic sclerosis (scleroderma).
Scheja A, Akesson A
Clin Exp Rheumatol 1997 May-Jun;15(3):283-8. PMID: 9177923
Quantification of acrosclerosis: measurement of skin thickness and skin-phalanx distance in females with 15 MHz pulsed ultrasound.
Serup J
Acta Derm Venereol 1984;64(1):35-40. PMID: 6203279

Therapy

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article

Prognosis

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis.
Akesson A, Hesselstrand R, Scheja A, Wildt M
Ann Rheum Dis 2004 Jul;63(7):791-6. doi: 10.1136/ard.2003.012146. PMID: 15194573Free PMC Article

Clinical prediction guides

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Reliability of ultrasound measurements of dermal thickness at digits in systemic sclerosis: role of elastosonography.
Di Geso L, Filippucci E, Girolimetti R, Tardella M, Gutierrez M, De Angelis R, Salaffi F, Grassi W
Clin Exp Rheumatol 2011 Nov-Dec;29(6):926-32. Epub 2011 Dec 22 PMID: 22032470
Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis.
Akesson A, Hesselstrand R, Scheja A, Wildt M
Ann Rheum Dis 2004 Jul;63(7):791-6. doi: 10.1136/ard.2003.012146. PMID: 15194573Free PMC Article
The treatment of dorsal fracture-dislocation of the proximal interphalangeal joint by closed reduction and Kirschner wire fixation: a 16-year follow up.
Newington DP, Davis TR, Barton NJ
J Hand Surg Br 2001 Dec;26(6):537-40. doi: 10.1054/jhsb.2001.0698. PMID: 11884107
Comparison of high frequency (20 MHz) ultrasound and palpation for the assessment of skin involvement in systemic sclerosis (scleroderma).
Scheja A, Akesson A
Clin Exp Rheumatol 1997 May-Jun;15(3):283-8. PMID: 9177923

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...