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Sclerosis of middle finger phalanx

MedGen UID:
866593
•Concept ID:
C4020939
•
Anatomical Abnormality
Synonyms: Increased bone density in middle finger bone of hand; Sclerosis of the middle phalanges of the hand
 
HPO: HP:0100916

Definition

An elevation in bone density in one or more middle phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity. [from HPO]

Professional guidelines

PubMed

Imaging Helps Guide Physical Therapy Treatment in a Patient With Diffuse Systemic Sclerosis (Scleroderma).
Curley RA, Markowski A
J Orthop Sports Phys Ther 2018 Mar;48(3):226. doi: 10.2519/jospt.2018.7662. PMID: 29490598

Recent clinical studies

Etiology

Photoacoustic imaging is a novel tool to measure finger artery structure and oxygenation in patients with SSc.
Wilkinson S, Cummings J, Zafar S, Kozar M, Manning J, Dinsdale G, Berks M, Taylor C, Dickinson M, Herrick AL, Murray AK
Sci Rep 2022 Nov 28;12(1):20446. doi: 10.1038/s41598-022-23826-1. PMID: 36443311Free PMC Article
The Role of Angiogenesis Factors in the Formation of Vascular Changes in Scleroderma by Assessment of the Concentrations of VEGF and sVEGFR2 in Blood Serum and Tear Fluid.
Waszczykowska A, Goś R, Waszczykowska E, Dziankowska-Bartkowiak B, Podgórski M, Jurowski P
Mediators Inflamm 2020;2020:7649480. Epub 2020 Jan 24 doi: 10.1155/2020/7649480. PMID: 32410862Free PMC Article
A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Imaging features of osteoid osteoma of the phalanges.
Kotnis N, James SL
Skeletal Radiol 2015 Oct;44(10):1461-6. Epub 2015 Jun 21 doi: 10.1007/s00256-015-2191-8. PMID: 26093538
Digital Ulcers in Systemic Sclerosis - Frequency, Subtype Distribution and Clinical Outcome.
Lambova S, Batalov A, Sapundzhiev L, Müller-Ladner U
Curr Rheumatol Rev 2013;9(4):268-73. doi: 10.2174/157339710904140417125627. PMID: 26932292

Diagnosis

Photoacoustic imaging is a novel tool to measure finger artery structure and oxygenation in patients with SSc.
Wilkinson S, Cummings J, Zafar S, Kozar M, Manning J, Dinsdale G, Berks M, Taylor C, Dickinson M, Herrick AL, Murray AK
Sci Rep 2022 Nov 28;12(1):20446. doi: 10.1038/s41598-022-23826-1. PMID: 36443311Free PMC Article
Correlations between blood perfusion and dermal thickness in different skin areas of systemic sclerosis patients.
Ruaro B, Sulli A, Pizzorni C, Paolino S, Smith V, Alessandri E, Trombetta AC, Alsheyyab J, Cutolo M
Microvasc Res 2018 Jan;115:28-33. Epub 2017 Aug 20 doi: 10.1016/j.mvr.2017.08.004. PMID: 28834709
Fingolimod-Associated Peripheral Vascular Adverse Effects.
Russo M, Guarneri C, Mazzon E, Sessa E, Bramanti P, Calabrò RS
Mayo Clin Proc 2015 Oct;90(10):1424-7. Epub 2015 Sep 5 doi: 10.1016/j.mayocp.2015.07.019. PMID: 26349949
Reliability of ultrasound measurements of dermal thickness at digits in systemic sclerosis: role of elastosonography.
Di Geso L, Filippucci E, Girolimetti R, Tardella M, Gutierrez M, De Angelis R, Salaffi F, Grassi W
Clin Exp Rheumatol 2011 Nov-Dec;29(6):926-32. Epub 2011 Dec 22 PMID: 22032470
Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis.
Akesson A, Hesselstrand R, Scheja A, Wildt M
Ann Rheum Dis 2004 Jul;63(7):791-6. doi: 10.1136/ard.2003.012146. PMID: 15194573Free PMC Article

Therapy

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Fingolimod-Associated Peripheral Vascular Adverse Effects.
Russo M, Guarneri C, Mazzon E, Sessa E, Bramanti P, Calabrò RS
Mayo Clin Proc 2015 Oct;90(10):1424-7. Epub 2015 Sep 5 doi: 10.1016/j.mayocp.2015.07.019. PMID: 26349949

Prognosis

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis.
Akesson A, Hesselstrand R, Scheja A, Wildt M
Ann Rheum Dis 2004 Jul;63(7):791-6. doi: 10.1136/ard.2003.012146. PMID: 15194573Free PMC Article

Clinical prediction guides

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Correlations between blood perfusion and dermal thickness in different skin areas of systemic sclerosis patients.
Ruaro B, Sulli A, Pizzorni C, Paolino S, Smith V, Alessandri E, Trombetta AC, Alsheyyab J, Cutolo M
Microvasc Res 2018 Jan;115:28-33. Epub 2017 Aug 20 doi: 10.1016/j.mvr.2017.08.004. PMID: 28834709
Digital Ulcers in Systemic Sclerosis - Frequency, Subtype Distribution and Clinical Outcome.
Lambova S, Batalov A, Sapundzhiev L, Müller-Ladner U
Curr Rheumatol Rev 2013;9(4):268-73. doi: 10.2174/157339710904140417125627. PMID: 26932292
Reliability of ultrasound measurements of dermal thickness at digits in systemic sclerosis: role of elastosonography.
Di Geso L, Filippucci E, Girolimetti R, Tardella M, Gutierrez M, De Angelis R, Salaffi F, Grassi W
Clin Exp Rheumatol 2011 Nov-Dec;29(6):926-32. Epub 2011 Dec 22 PMID: 22032470
Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis.
Akesson A, Hesselstrand R, Scheja A, Wildt M
Ann Rheum Dis 2004 Jul;63(7):791-6. doi: 10.1136/ard.2003.012146. PMID: 15194573Free PMC Article

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