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Pseudo-fractures

MedGen UID:
866681
•Concept ID:
C4021028
•
Anatomical Abnormality
Synonym: Looser zones
 
HPO: HP:0100036

Definition

A band of bone material of decreased density forming alongside the surface of the cortical bone with thickening of the periosteum. Callus formation in the affected area is common and gives the appearance of a false fracture. [from HPO]

Professional guidelines

PubMed

Changes in bone mineral density following treatment of osteomalacia.
Bhambri R, Naik V, Malhotra N, Taneja S, Rastogi S, Ravishanker U, Mithal A
J Clin Densitom 2006 Jan-Mar;9(1):120-7. Epub 2006 Mar 27 doi: 10.1016/j.jocd.2005.11.001. PMID: 16731441

Recent clinical studies

Etiology

Burden of disease associated with X-linked hypophosphataemia in adults: a systematic literature review.
Seefried L, Smyth M, Keen R, Harvengt P
Osteoporos Int 2021 Jan;32(1):7-22. Epub 2020 Jul 24 doi: 10.1007/s00198-020-05548-0. PMID: 32710160Free PMC Article
Phenytoin induced severe disabling osteomalacia in a young male with seizure disorder.
Khaira A, Gupta A, Madhu SV, Khaira DD
J Assoc Physicians India 2008 May;56:376-8. PMID: 18700645
Changes in bone mineral density following treatment of osteomalacia.
Bhambri R, Naik V, Malhotra N, Taneja S, Rastogi S, Ravishanker U, Mithal A
J Clin Densitom 2006 Jan-Mar;9(1):120-7. Epub 2006 Mar 27 doi: 10.1016/j.jocd.2005.11.001. PMID: 16731441
A potential risk for osteomalacia due to sociocultural lifestyle in Turkish women.
Güllü S, Erdoğan MF, Uysal AR, Başkal N, Kamel AN, Erdoğan G
Endocr J 1998 Oct;45(5):675-8. doi: 10.1507/endocrj.45.675. PMID: 10395248

Diagnosis

The Right Leg that Troubled the Left Leg.
B S, V A
J Assoc Physicians India 2023 Jan;71(1):1. PMID: 37116017
X-linked hypophosphatemia and burosumab: Practical clinical points from the French experience.
Bacchetta J, Rothenbuhler A, Gueorguieva I, Kamenicky P, Salles JP, Briot K, Linglart A
Joint Bone Spine 2021 Oct;88(5):105208. Epub 2021 Jun 6 doi: 10.1016/j.jbspin.2021.105208. PMID: 34102329
Occult phosphaturic mesenchymal tumour of femur cortex causing oncogenic osteomalacia - diagnostic challenges and clinical outcomes.
Dutta D, Pandey RK, Gogoi R, Solanki N, Madan R, Mondal A, Dogra S, Thapa P
Endokrynol Pol 2018;69(2):205-210. Epub 2018 Feb 14 doi: 10.5603/EP.a2018.0016. PMID: 29442350
Hypophosphataemic rickets/osteomalacia: a descriptive analysis.
Bhadada SK, Bhansali A, Upreti V, Dutta P, Santosh R, Das S, Nahar U
Indian J Med Res 2010 Mar;131:399-404. PMID: 20418553
Spinal deformities and pseudofractures.
Boechat MI
AJR Am J Roentgenol 1987 Jan;148(1):97-8. doi: 10.2214/ajr.148.1.97. PMID: 3491529

Therapy

Efficacy of Burosumab in Adults with X-linked Hypophosphatemia (XLH): A Post Hoc Subgroup Analysis of a Randomized Double-Blind Placebo-Controlled Phase 3 Study.
Brandi ML, Jan de Beur S, Briot K, Carpenter T, Cheong HI, Cohen-Solal M, Crowley RK, Eastell R, Imanishi Y, Imel EA, Ing SW, Insogna K, Ito N, Javaid K, Kamenicky P, Keen R, Kubota T, Lachmann RH, Perwad F, Pitukcheewanont P, Portale A, Ralston SH, Tanaka H, Weber TJ, Yoo HW, Sun W, Williams A, Nixon A, Takeuchi Y
Calcif Tissue Int 2022 Oct;111(4):409-418. Epub 2022 Aug 4 doi: 10.1007/s00223-022-01006-7. PMID: 35927518
Occult phosphaturic mesenchymal tumour of femur cortex causing oncogenic osteomalacia - diagnostic challenges and clinical outcomes.
Dutta D, Pandey RK, Gogoi R, Solanki N, Madan R, Mondal A, Dogra S, Thapa P
Endokrynol Pol 2018;69(2):205-210. Epub 2018 Feb 14 doi: 10.5603/EP.a2018.0016. PMID: 29442350
Phenytoin induced severe disabling osteomalacia in a young male with seizure disorder.
Khaira A, Gupta A, Madhu SV, Khaira DD
J Assoc Physicians India 2008 May;56:376-8. PMID: 18700645
Changes in bone mineral density following treatment of osteomalacia.
Bhambri R, Naik V, Malhotra N, Taneja S, Rastogi S, Ravishanker U, Mithal A
J Clin Densitom 2006 Jan-Mar;9(1):120-7. Epub 2006 Mar 27 doi: 10.1016/j.jocd.2005.11.001. PMID: 16731441

Prognosis

Tumour induced osteopenia due to phosphaturic mesenchymal sinonasal tumour presenting with delayed onset insufficiency fractures.
Jawan F, Lim W, Francis J
J Radiol Case Rep 2023 Jul;17(7):8-16. Epub 2023 Jul 31 doi: 10.3941/jrcr.v17i7.4912. PMID: 37602195Free PMC Article
The Right Leg that Troubled the Left Leg.
B S, V A
J Assoc Physicians India 2023 Jan;71(1):1. PMID: 37116017

Clinical prediction guides

Efficacy of Burosumab in Adults with X-linked Hypophosphatemia (XLH): A Post Hoc Subgroup Analysis of a Randomized Double-Blind Placebo-Controlled Phase 3 Study.
Brandi ML, Jan de Beur S, Briot K, Carpenter T, Cheong HI, Cohen-Solal M, Crowley RK, Eastell R, Imanishi Y, Imel EA, Ing SW, Insogna K, Ito N, Javaid K, Kamenicky P, Keen R, Kubota T, Lachmann RH, Perwad F, Pitukcheewanont P, Portale A, Ralston SH, Tanaka H, Weber TJ, Yoo HW, Sun W, Williams A, Nixon A, Takeuchi Y
Calcif Tissue Int 2022 Oct;111(4):409-418. Epub 2022 Aug 4 doi: 10.1007/s00223-022-01006-7. PMID: 35927518
Hypophosphataemic rickets/osteomalacia: a descriptive analysis.
Bhadada SK, Bhansali A, Upreti V, Dutta P, Santosh R, Das S, Nahar U
Indian J Med Res 2010 Mar;131:399-404. PMID: 20418553

Recent systematic reviews

Burden of disease associated with X-linked hypophosphataemia in adults: a systematic literature review.
Seefried L, Smyth M, Keen R, Harvengt P
Osteoporos Int 2021 Jan;32(1):7-22. Epub 2020 Jul 24 doi: 10.1007/s00198-020-05548-0. PMID: 32710160Free PMC Article

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