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Anti-muscle-specific tyrosine kinase antibody

MedGen UID:
866697
•Concept ID:
C4021044
•
Finding
Synonyms: Anti-MUSK antibodies; Muscle specific kinase antibody positivity
 
HPO: HP:0030210

Definition

The presence of autoantibodies (immunoglobulins) in the serum that react against muscle specific kinase (anti-MuSK Ab). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-muscle-specific tyrosine kinase antibody

Professional guidelines

PubMed

Response to treatment of myasthenia gravis according to clinical subtype.
Akaishi T, Suzuki Y, Imai T, Tsuda E, Minami N, Nagane Y, Uzawa A, Kawaguchi N, Masuda M, Konno S, Suzuki H, Murai H, Aoki M, Utsugisawa K
BMC Neurol 2016 Nov 17;16(1):225. doi: 10.1186/s12883-016-0756-3. PMID: 27855632Free PMC Article

Recent clinical studies

Etiology

Characteristics of myasthenia gravis in elderly patients: a retrospective study.
Li Y, Dong X, Li Z, Peng Y, Jin W, Zhou R, Jiang F, Xu L, Luo Z, Yang H
Neurol Sci 2022 Apr;43(4):2775-2783. Epub 2021 Oct 22 doi: 10.1007/s10072-021-05599-z. PMID: 34677704
Prompt Response to Prednisone Predicts Benign Course in MuSK-MG.
Gungor-Tuncer O, Yilmaz V, Toker A, Saruhan-Direskeneli G, Gulsen-Parman Y, Oflazer-Serdaroglu P, Deymeer F
Eur Neurol 2017;78(3-4):137-142. Epub 2017 Jul 28 doi: 10.1159/000479228. PMID: 28768265
Clinical and immunological differences between early and late-onset myasthenia gravis in Japan.
Suzuki S, Utsugisawa K, Nagane Y, Satoh T, Kuwana M, Suzuki N
J Neuroimmunol 2011 Jan;230(1-2):148-52. Epub 2010 Nov 12 doi: 10.1016/j.jneuroim.2010.10.023. PMID: 21074862

Diagnosis

Bilateral vocal fold paresis: the only presenting sign of anti-MUSK antibody myasthenia gravis.
Arman S, Kock N, Mochloulis G, Kanabar G
BMJ Case Rep 2021 Jan 12;14(1) doi: 10.1136/bcr-2019-234070. PMID: 33436356Free PMC Article
Myasthenic Crisis Complicated with Myxedema, Positive for Both Anti-acetylcholine Receptor and Anti-muscle-specific Tyrosine Kinase Antibodies.
Horiuchi K, Nagai A, Wakita M, Ito S, Takamura K, Houzen H
Intern Med 2018 Jan 15;57(2):265-268. Epub 2017 Nov 1 doi: 10.2169/internalmedicine.9291-17. PMID: 29093409Free PMC Article

Therapy

Bilateral vocal fold paresis: the only presenting sign of anti-MUSK antibody myasthenia gravis.
Arman S, Kock N, Mochloulis G, Kanabar G
BMJ Case Rep 2021 Jan 12;14(1) doi: 10.1136/bcr-2019-234070. PMID: 33436356Free PMC Article
Longstanding and Refractory Anti-Muscle Specific Tyrosine Kinase Antibody-Associated Myasthenia Gravis (Anti-MuSK-MG) in a Child Successfully Treated with Rituximab.
Weger S, Appendino JP, Clark IH
J Binocul Vis Ocul Motil 2019 Jan-Mar;69(1):26-29. Epub 2019 Feb 27 doi: 10.1080/2576117X.2019.1578164. PMID: 30811277
Myasthenic Crisis Complicated with Myxedema, Positive for Both Anti-acetylcholine Receptor and Anti-muscle-specific Tyrosine Kinase Antibodies.
Horiuchi K, Nagai A, Wakita M, Ito S, Takamura K, Houzen H
Intern Med 2018 Jan 15;57(2):265-268. Epub 2017 Nov 1 doi: 10.2169/internalmedicine.9291-17. PMID: 29093409Free PMC Article
Prompt Response to Prednisone Predicts Benign Course in MuSK-MG.
Gungor-Tuncer O, Yilmaz V, Toker A, Saruhan-Direskeneli G, Gulsen-Parman Y, Oflazer-Serdaroglu P, Deymeer F
Eur Neurol 2017;78(3-4):137-142. Epub 2017 Jul 28 doi: 10.1159/000479228. PMID: 28768265

Prognosis

Characteristics of myasthenia gravis in elderly patients: a retrospective study.
Li Y, Dong X, Li Z, Peng Y, Jin W, Zhou R, Jiang F, Xu L, Luo Z, Yang H
Neurol Sci 2022 Apr;43(4):2775-2783. Epub 2021 Oct 22 doi: 10.1007/s10072-021-05599-z. PMID: 34677704
Bilateral vocal fold paresis: the only presenting sign of anti-MUSK antibody myasthenia gravis.
Arman S, Kock N, Mochloulis G, Kanabar G
BMJ Case Rep 2021 Jan 12;14(1) doi: 10.1136/bcr-2019-234070. PMID: 33436356Free PMC Article
Longstanding and Refractory Anti-Muscle Specific Tyrosine Kinase Antibody-Associated Myasthenia Gravis (Anti-MuSK-MG) in a Child Successfully Treated with Rituximab.
Weger S, Appendino JP, Clark IH
J Binocul Vis Ocul Motil 2019 Jan-Mar;69(1):26-29. Epub 2019 Feb 27 doi: 10.1080/2576117X.2019.1578164. PMID: 30811277
Prompt Response to Prednisone Predicts Benign Course in MuSK-MG.
Gungor-Tuncer O, Yilmaz V, Toker A, Saruhan-Direskeneli G, Gulsen-Parman Y, Oflazer-Serdaroglu P, Deymeer F
Eur Neurol 2017;78(3-4):137-142. Epub 2017 Jul 28 doi: 10.1159/000479228. PMID: 28768265
Childhood-onset anti-MuSK antibody positive myasthenia gravis demonstrates a distinct clinical course.
Takahashi Y, Sugiyama M, Ueda Y, Itoh T, Yagyu K, Shiraishi H, Ukeba-Terashita Y, Nakanishi M, Nagashima T, Imai T, Motomura M, Saitoh S
Brain Dev 2012 Oct;34(9):784-6. Epub 2012 Jan 25 doi: 10.1016/j.braindev.2011.12.014. PMID: 22277190

Clinical prediction guides

Prompt Response to Prednisone Predicts Benign Course in MuSK-MG.
Gungor-Tuncer O, Yilmaz V, Toker A, Saruhan-Direskeneli G, Gulsen-Parman Y, Oflazer-Serdaroglu P, Deymeer F
Eur Neurol 2017;78(3-4):137-142. Epub 2017 Jul 28 doi: 10.1159/000479228. PMID: 28768265

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