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Abnormal circulating fatty-acid anion concentration

MedGen UID:
866854
•Concept ID:
C4021209
•
Finding
Synonym: Abnormality of fatty-acid anion metabolism
 
HPO: HP:0010966

Definition

Any deviation from the normal concentration of a fatty acid anion in the blood circulation. [from HPO]

Recent clinical studies

Etiology

Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm.
Abumrad N, Coburn C, Ibrahimi A
Biochim Biophys Acta 1999 Oct 18;1441(1):4-13. doi: 10.1016/s1388-1981(99)00137-7. PMID: 10526223

Diagnosis

Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991

Therapy

Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
The nutritional/metabolic and hormonal effects of 8 weeks of continuous ambulatory peritoneal dialysis with a 1% amino acid solution.
Arfeen S, Goodship TH, Kirkwood A, Ward MK
Clin Nephrol 1990 Apr;33(4):192-99. PMID: 2190721
The metabolic effects of fatal cyanide poisoning.
Singh BM, Coles N, Lewis P, Braithwaite RA, Nattrass M, FitzGerald MG
Postgrad Med J 1989 Dec;65(770):923-5. doi: 10.1136/pgmj.65.770.923. PMID: 2616434Free PMC Article

Prognosis

Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991

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