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EEG with periodic lateralized epileptiform discharges

MedGen UID:: 866860
•Concept ID:: C4021215
•: Finding

Synonym:	EEG: periodic lateralized epileptiform discharges

HPO:	HP:0010853

Definition

Periodic lateralized epileptiform discharges (PLEDs)are periodic, lateralized, and epileptiform. PLEDs show a relatively constant interval between discharges (0.5 to 3 seconds). [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVEEG with periodic lateralized epileptiform discharges

Abnormality of central nervous system electrophysiology
- EEG abnormality
  - Interictal EEG abnormality
    - Interictal epileptiform activity
      - EEG with focal epileptiform discharges
        Focal epileptiform discharges with limited propagation to contralateral hemisphere
        EEG with periodic lateralized epileptiform discharges

Professional guidelines

PubMed

Immediate and long-term management practices of acute symptomatic seizures and epileptiform abnormalities: A cross-sectional international survey.

Punia V, Daruvala S, Dhakar MB, Zafar SF, Rubinos C, Ayub N, Hirsch LJ, Sivaraju A; for Post‐Acute Symptomatic Seizure Investigation and Outcomes Network (PASSION) investigators
Epilepsia 2024 Apr;65(4):909-919. Epub 2024 Feb 15 doi: 10.1111/epi.17915. PMID: 38358383

Epileptiform Abnormalities in Acute Ischemic Stroke: Impact on Clinical Management and Outcomes.

Dhakar MB, Sheikh Z, Kumari P, Lawson EC, Jeanneret V, Desai D, Rodriguez Ruiz A, Haider HA
J Clin Neurophysiol 2022 Sep 1;39(6):446-452. Epub 2020 Dec 8 doi: 10.1097/WNP.0000000000000801. PMID: 33298681 Free PMC Article

Periodic lateralized epileptiform discharges: Do they represent an ictal pattern requiring treatment?

Hughes JR
Epilepsy Behav 2010 Jul;18(3):162-5. Epub 2010 May 31 doi: 10.1016/j.yebeh.2010.04.047. PMID: 20554251

See all (4)

Recent clinical studies

Etiology

High incidence of epileptiform activity in adults undergoing extracorporeal membrane oxygenation.

Amorim E, Firme MS, Zheng WL, Shelton KT, Akeju O, Cudemus G, Yuval R, Westover MB
Clin Neurophysiol 2022 Aug;140:4-11. Epub 2022 May 6 doi: 10.1016/j.clinph.2022.04.018. PMID: 35691268 Free PMC Article

Epileptiform Abnormalities in Acute Ischemic Stroke: Impact on Clinical Management and Outcomes.

Simultaneous Electroencephalographic and Electocorticographic Recordings of Lateralized Periodic Discharges in Temporal Lobe Epilepsy.

Sakata A, Mukae N, Morioka T, Tanaka S, Shimogawa T, Shigeto H, Hotta T, Kang D, Mizoguchi M
Clin EEG Neurosci 2022 Jan;53(1):61-69. Epub 2020 Nov 11 doi: 10.1177/1550059420972266. PMID: 33172294

Should epileptiform discharges be treated?

Sánchez Fernández I, Loddenkemper T, Galanopoulou AS, Moshé SL
Epilepsia 2015 Oct;56(10):1492-504. Epub 2015 Aug 21 doi: 10.1111/epi.13108. PMID: 26293670 Free PMC Article

Alcohol withdrawal seizures.

Hughes JR
Epilepsy Behav 2009 Jun;15(2):92-7. Epub 2009 Feb 26 doi: 10.1016/j.yebeh.2009.02.037. PMID: 19249388

See all (120)

Diagnosis

Simultaneous Electroencephalographic and Electocorticographic Recordings of Lateralized Periodic Discharges in Temporal Lobe Epilepsy.

Sakata A, Mukae N, Morioka T, Tanaka S, Shimogawa T, Shigeto H, Hotta T, Kang D, Mizoguchi M
Clin EEG Neurosci 2022 Jan;53(1):61-69. Epub 2020 Nov 11 doi: 10.1177/1550059420972266. PMID: 33172294

Lateralized Periodic Discharges: A Literature Review.

Lin L, Drislane FW
J Clin Neurophysiol 2018 May;35(3):189-198. doi: 10.1097/WNP.0000000000000448. PMID: 29718828

Which EEG patterns in coma are nonconvulsive status epilepticus?

Trinka E, Leitinger M
Epilepsy Behav 2015 Aug;49:203-22. Epub 2015 Jul 4 doi: 10.1016/j.yebeh.2015.05.005. PMID: 26148985

EEG of partial seizures.

Verma A, Radtke R
J Clin Neurophysiol 2006 Aug;23(4):333-9. doi: 10.1097/01.wnp.0000228497.89734.7a. PMID: 16885707

Is it status?

Brenner RP
Epilepsia 2002;43 Suppl 3:103-13. doi: 10.1046/j.1528-1157.43.s.3.9.x. PMID: 12060012

See all (167)

Therapy

Ictal EEG: Etiology and Mortality in Older Adults With Nonconvulsive Status Epilepticus.

Tedrus GMAS
Clin EEG Neurosci 2024 Mar;55(2):278-282. Epub 2023 Jul 27 doi: 10.1177/15500594231183554. PMID: 37498994

EEG Correlates of Delirium in Children and Young Adults With CD19-Directed CAR T Cell Treatment-Related Neurotoxicity.

Gust J, Annesley CE, Gardner RA, Bozarth X
J Clin Neurophysiol 2021 Mar 1;38(2):135-142. doi: 10.1097/WNP.0000000000000669. PMID: 31851018 Free PMC Article

Periodic focal epileptiform discharges.

Tatum WO, Feyissa AM, ReFaey K, Grewal SS, Alvi MA, Castro-Apolo R, Roth G, Segura-Duran I, Mahato D, Ruiz-Garcia H, Pamias-Portalatin E, Yelvington K, Chaichana K, Bechtle P, Quinones-Hinojosa A
Clin Neurophysiol 2019 Aug;130(8):1320-1328. Epub 2019 May 31 doi: 10.1016/j.clinph.2019.04.718. PMID: 31185363

Periodic lateralized epileptiform discharges: Do they represent an ictal pattern requiring treatment?

Hughes JR
Epilepsy Behav 2010 Jul;18(3):162-5. Epub 2010 May 31 doi: 10.1016/j.yebeh.2010.04.047. PMID: 20554251

Structural lesions in periodic lateralized epileptiform discharges (PLEDs).

Gurer G, Yemisci M, Saygi S, Ciger A
Clin EEG Neurosci 2004 Apr;35(2):88-93. doi: 10.1177/155005940403500207. PMID: 15164816

See all (61)

Prognosis

High incidence of epileptiform activity in adults undergoing extracorporeal membrane oxygenation.

Electrographic and Clinical Natural History of Lateralized Periodic Discharges.

Punia V, Vakani R, Burgess R, Hantus S
J Clin Neurophysiol 2018 Jan;35(1):71-76. doi: 10.1097/WNP.0000000000000428. PMID: 29099408

MTLE with hippocampal sclerosis in adult as a syndrome.

Baulac M
Rev Neurol (Paris) 2015 Mar;171(3):259-66. Epub 2015 Feb 26 doi: 10.1016/j.neurol.2015.02.004. PMID: 25727907

The EEG of status epilepticus.

Kaplan PW
J Clin Neurophysiol 2006 Jun;23(3):221-9. doi: 10.1097/01.wnp.0000220837.99490.66. PMID: 16751722

Is it status?

Brenner RP
Epilepsia 2002;43 Suppl 3:103-13. doi: 10.1046/j.1528-1157.43.s.3.9.x. PMID: 12060012

See all (99)

Clinical prediction guides

High incidence of epileptiform activity in adults undergoing extracorporeal membrane oxygenation.

Simultaneous Electroencephalographic and Electocorticographic Recordings of Lateralized Periodic Discharges in Temporal Lobe Epilepsy.

Sakata A, Mukae N, Morioka T, Tanaka S, Shimogawa T, Shigeto H, Hotta T, Kang D, Mizoguchi M
Clin EEG Neurosci 2022 Jan;53(1):61-69. Epub 2020 Nov 11 doi: 10.1177/1550059420972266. PMID: 33172294

Periodic Discharges: Insight From Magnetoencephalography.

Shvarts V, Zoltay G, Bowyer SM, Zillgitt A, Moran JE, Mason K, Tepley N, Burdette D
J Clin Neurophysiol 2017 May;34(3):196-206. doi: 10.1097/WNP.0000000000000356. PMID: 27832046

Interictal epileptiform discharge effects on neuropsychological assessment and epilepsy surgical planning.

Drane DL, Ojemann JG, Kim MS, Gross RE, Miller JW, Faught RE Jr, Loring DW
Epilepsy Behav 2016 Mar;56:131-8. Epub 2016 Feb 12 doi: 10.1016/j.yebeh.2016.01.001. PMID: 26874864 Free PMC Article

Periodic Lateralized Epileptiform Discharges and Afterdischarges: Common Dynamic Mechanisms.

Kalamangalam GP, Slater JD
J Clin Neurophysiol 2015 Aug;32(4):331-40. doi: 10.1097/WNP.0000000000000173. PMID: 25710632 Free PMC Article

See all (86)

Recent systematic reviews

Systematic review of EEG findings in 617 patients diagnosed with COVID-19.

Antony AR, Haneef Z
Seizure 2020 Dec;83:234-241. Epub 2020 Oct 19 doi: 10.1016/j.seizure.2020.10.014. PMID: 33121875 Free PMC Article

See all (1)

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EEG with periodic lateralized epileptiform discharges

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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