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Short 4th finger

MedGen UID:
867144
•Concept ID:
C4021502
•
Congenital Abnormality
Synonyms: Hypoplastic/small 4th finger; Short ring finger
 
HPO: HP:0009280

Definition

Hypoplasia (congenital reduction in size) of the fourth finger, also known as the ring finger. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVShort 4th finger

Recent clinical studies

Etiology

On-top plasty using a free metacarpal head graft for lengthening of proximal phalanx in symbrachydactyly--a case report.
Iba K, Wada T, Yamashita T
Hand Surg 2013;18(2):273-5. doi: 10.1142/S0218810413720192. PMID: 24164137
Evaluation of qualitative methods for phenotyping brachymesophalangia-V from radiographs of children.
Williams KD, Nahhas RW, Cottom CR, Lawrence S, Subedi J, Jha B, Czerwinski SA, Blangero J, Williams-Blangero S, Towne B
Am J Hum Biol 2012 Jan-Feb;24(1):68-73. Epub 2011 Dec 1 doi: 10.1002/ajhb.22205. PMID: 22131202Free PMC Article
The ratio of 2nd to 4th digit length: a proxy for transactivation activity of the androgen receptor gene?
Manning JT, Bundred PE, Flanagan BF
Med Hypotheses 2002 Sep;59(3):334-6. doi: 10.1016/s0306-9877(02)00181-0. PMID: 12208164
Diagnostic value of hand X-rays in Turner's syndrome.
Necić S, Grant DB
Acta Paediatr Scand 1978 May;67(3):309-12. doi: 10.1111/j.1651-2227.1978.tb16326.x. PMID: 654909

Diagnosis

Ophthalmo-acromelic syndrome in an infant.
Ürel-Demir G, Taşkıran EZ, Akgün-Doğan Ö, Şimşek-Kiper PÖ, Utine GE
Eur J Med Genet 2019 Jul;62(7):103664. Epub 2019 May 5 doi: 10.1016/j.ejmg.2019.05.003. PMID: 31067494
Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction: A case report and literature review.
Angkathunyakul N, Treepongkaruna S, Molagool S, Ruangwattanapaisarn N
World J Gastroenterol 2015 Jun 14;21(22):7059-64. doi: 10.3748/wjg.v21.i22.7059. PMID: 26078585Free PMC Article
How many entities exist for the spectrum of disorders associated with brachydactyly, syndactyly, short stature, microcephaly, and intellectual disability?
Ravel A, Chouery E, Stora S, Jalkh N, Villard L, Temtamy S, Mégarbané A
Am J Med Genet A 2011 Apr;155A(4):880-4. Epub 2011 Mar 17 doi: 10.1002/ajmg.a.33879. PMID: 21416592
The ratio of 2nd to 4th digit length: a proxy for transactivation activity of the androgen receptor gene?
Manning JT, Bundred PE, Flanagan BF
Med Hypotheses 2002 Sep;59(3):334-6. doi: 10.1016/s0306-9877(02)00181-0. PMID: 12208164
Diagnostic value of hand X-rays in Turner's syndrome.
Necić S, Grant DB
Acta Paediatr Scand 1978 May;67(3):309-12. doi: 10.1111/j.1651-2227.1978.tb16326.x. PMID: 654909

Therapy

Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction: A case report and literature review.
Angkathunyakul N, Treepongkaruna S, Molagool S, Ruangwattanapaisarn N
World J Gastroenterol 2015 Jun 14;21(22):7059-64. doi: 10.3748/wjg.v21.i22.7059. PMID: 26078585Free PMC Article
Pseudoaminopterin syndrome: clinical report with new characteristics.
Sobreira N, Cernach M, Batista D, Brunoni D, Perez A
Am J Med Genet A 2009 Dec;149A(12):2843-8. doi: 10.1002/ajmg.a.33125. PMID: 19938091
Testing the prenatal androgen hypothesis: measuring digit ratios, sexual orientation, and spatial abilities in adults.
van Anders SM, Hampson E
Horm Behav 2005 Jan;47(1):92-8. doi: 10.1016/j.yhbeh.2004.09.003. PMID: 15579270
Neurobehavioral Evaluation System (NES): comparative performance of 2nd-, 4th-, and 8th-grade Czech children.
Otto DA, Skalik I, House DE, Hudnell HK
Neurotoxicol Teratol 1996 Jul-Aug;18(4):421-8. doi: 10.1016/0892-0362(96)00036-0. PMID: 8866533
Short-term changes of finger representation at the somatosensory cortex in humans.
Buchner H, Kauert C, Radermacher I
Neurosci Lett 1995 Sep 22;198(1):57-9. doi: 10.1016/0304-3940(95)11950-2. PMID: 8570097

Prognosis

On-top plasty using a free metacarpal head graft for lengthening of proximal phalanx in symbrachydactyly--a case report.
Iba K, Wada T, Yamashita T
Hand Surg 2013;18(2):273-5. doi: 10.1142/S0218810413720192. PMID: 24164137
The ratio of 2nd to 4th digit length: a proxy for transactivation activity of the androgen receptor gene?
Manning JT, Bundred PE, Flanagan BF
Med Hypotheses 2002 Sep;59(3):334-6. doi: 10.1016/s0306-9877(02)00181-0. PMID: 12208164

Clinical prediction guides

Biallelic ZNF407 mutations in a neurodevelopmental disorder with ID, short stature and variable microcephaly, hypotonia, ocular anomalies and facial dysmorphism.
Zahra Q, Çakmak Ç, Koprulu M, Shuaib M, Sobreira N, Kalsner L, Sobreira J, Guillen Sacoto MJ, Malik S, Tolun A
J Hum Genet 2020 Dec;65(12):1115-1123. Epub 2020 Jul 31 doi: 10.1038/s10038-020-0812-0. PMID: 32737394
Custom-made silicone hand prosthesis: A case study.
Nayak S, Lenka PK, Equebal A, Biswas A
Hand Surg Rehabil 2016 Sep;35(4):299-303. Epub 2016 Jul 21 doi: 10.1016/j.hansur.2016.05.004. PMID: 27781997
The ratio of 2nd to 4th digit length: a proxy for transactivation activity of the androgen receptor gene?
Manning JT, Bundred PE, Flanagan BF
Med Hypotheses 2002 Sep;59(3):334-6. doi: 10.1016/s0306-9877(02)00181-0. PMID: 12208164
Neurobehavioral Evaluation System (NES): comparative performance of 2nd-, 4th-, and 8th-grade Czech children.
Otto DA, Skalik I, House DE, Hudnell HK
Neurotoxicol Teratol 1996 Jul-Aug;18(4):421-8. doi: 10.1016/0892-0362(96)00036-0. PMID: 8866533

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