U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Laryngeal cartilage malformation

MedGen UID:
867172
•Concept ID:
C4021530
•
Anatomical Abnormality
Synonym: Vocal impairment, severe, due to laryngeal cartilage abnormalities
 
HPO: HP:0008752

Definition

A malformation of the laryngeal cartilage. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal cartilage malformation

Professional guidelines

PubMed

Complex Airway Management in Patients with Tracheal Cartilaginous Sleeves.
Noble AR, Cunningham ML, Lam A, Wenger TL, Sie KC, Perkins JA, Dahl JP
Laryngoscope 2022 Jan;132(1):215-221. Epub 2021 Jun 16 doi: 10.1002/lary.29692. PMID: 34133757
Management of laryngomalacia.
Ayari S, Aubertin G, Girschig H, Van Den Abbeele T, Denoyelle F, Couloignier V, Mondain M
Eur Ann Otorhinolaryngol Head Neck Dis 2013 Feb;130(1):15-21. Epub 2012 Jul 24 doi: 10.1016/j.anorl.2012.04.003. PMID: 22835508
Posterior glottic stenosis and bilateral vocal fold immobility: diagnosis and treatment.
Gardner GM
Otolaryngol Clin North Am 2000 Aug;33(4):855-78. doi: 10.1016/s0030-6665(05)70248-6. PMID: 10918665

Recent clinical studies

Etiology

Histopathology of laryngomalacia.
Gan RWC, Moustafa A, Turner K, Knight L
Acta Otolaryngol 2021 Jan;141(1):85-88. Epub 2020 Oct 14 doi: 10.1080/00016489.2020.1821246. PMID: 33393421
Subglottic Stenosis.
Marston AP, White DR
Clin Perinatol 2018 Dec;45(4):787-804. Epub 2018 Aug 27 doi: 10.1016/j.clp.2018.07.013. PMID: 30396418
Laryngeal Split and Rib Cartilage Interpositional Grafting: Treatment Option for Glottic and Subglottic Stenosis in Adults.
Hasan W, Gullane P
Thorac Surg Clin 2018 May;28(2):189-197. doi: 10.1016/j.thorsurg.2018.01.013. PMID: 29627053
Laryngeal anomalies: Pitfalls in adult forensic autopsies.
Advenier AS, De La Grandmaison GL, Cavard S, Pyatigorskaya N, Malicier D, Charlier P
Med Sci Law 2014 Jan;54(1):1-7. Epub 2013 Jun 26 doi: 10.1177/0025802413485731. PMID: 23804583
Laryngeal electromyography.
Heman-Ackah YD, Mandel S, Manon-Espaillat R, Abaza MM, Sataloff RT
Otolaryngol Clin North Am 2007 Oct;40(5):1003-23, vi-vii. doi: 10.1016/j.otc.2007.05.007. PMID: 17765693

Diagnosis

Subglottic Stenosis.
Marston AP, White DR
Clin Perinatol 2018 Dec;45(4):787-804. Epub 2018 Aug 27 doi: 10.1016/j.clp.2018.07.013. PMID: 30396418
Subglottic stenosis.
Jefferson ND, Cohen AP, Rutter MJ
Semin Pediatr Surg 2016 Jun;25(3):138-43. Epub 2016 Feb 20 doi: 10.1053/j.sempedsurg.2016.02.006. PMID: 27301599
Laryngomalacia.
Bedwell J, Zalzal G
Semin Pediatr Surg 2016 Jun;25(3):119-22. Epub 2016 Feb 18 doi: 10.1053/j.sempedsurg.2016.02.004. PMID: 27301595
Congenital laryngeal stenosis.
Schroeder JW Jr, Holinger LD
Otolaryngol Clin North Am 2008 Oct;41(5):865-75, viii. doi: 10.1016/j.otc.2008.04.015. PMID: 18775338
Laryngeal electromyography.
Heman-Ackah YD, Mandel S, Manon-Espaillat R, Abaza MM, Sataloff RT
Otolaryngol Clin North Am 2007 Oct;40(5):1003-23, vi-vii. doi: 10.1016/j.otc.2007.05.007. PMID: 17765693

Therapy

Neonatal Lateral Epiglottic Defects.
Peterson JD, Goyal V, Puricelli MD, Thatcher A, Smith RJ
Ann Otol Rhinol Laryngol 2021 Mar;130(3):311-313. Epub 2020 Aug 8 doi: 10.1177/0003489420948546. PMID: 32772542
Rigid airway.
Itagane M, Yano H, Kishaba T, Kinjo M
Cleve Clin J Med 2020 Jun;87(6):334-336. doi: 10.3949/ccjm.87a.19129. PMID: 32487551
Multidetector CT of Laryngeal Injuries: Principles of Injury Recognition.
Shi J, Uyeda JW, Duran-Mendicuti A, Potter CA, Nunez DB
Radiographics 2019 May-Jun;39(3):879-892. Epub 2019 Apr 12 doi: 10.1148/rg.2019180076. PMID: 30978150
Laryngeal Split and Rib Cartilage Interpositional Grafting: Treatment Option for Glottic and Subglottic Stenosis in Adults.
Hasan W, Gullane P
Thorac Surg Clin 2018 May;28(2):189-197. doi: 10.1016/j.thorsurg.2018.01.013. PMID: 29627053
Management of laryngomalacia.
Ayari S, Aubertin G, Girschig H, Van Den Abbeele T, Denoyelle F, Couloignier V, Mondain M
Eur Ann Otorhinolaryngol Head Neck Dis 2013 Feb;130(1):15-21. Epub 2012 Jul 24 doi: 10.1016/j.anorl.2012.04.003. PMID: 22835508

Prognosis

Histoanatomical structures of laryngeal atresia: Functional considerations.
Fayoux P, Devisme L
Laryngoscope 2020 Jan;130(1):252-256. Epub 2019 Feb 8 doi: 10.1002/lary.27855. PMID: 30734293
Partial Cricotracheal Resection and Extended Cricotracheal Resection for Pediatric Laryngotracheal Stenosis.
Monnier P
Thorac Surg Clin 2018 May;28(2):177-187. doi: 10.1016/j.thorsurg.2018.01.012. PMID: 29627052
The laryngeal saccule: clinical significance.
Porter PW, Vilensky JA
Clin Anat 2012 Jul;25(5):647-9. Epub 2011 Dec 12 doi: 10.1002/ca.22015. PMID: 22162142
Electromyography and the immobile vocal fold.
Sulica L, Blitzer A
Otolaryngol Clin North Am 2004 Feb;37(1):59-74. doi: 10.1016/S0030-6665(03)00168-3. PMID: 15062687
Laryngotracheoesophageal cleft.
Chaloryoo S
J Med Assoc Thai 1994 Apr;77(4):220-4. PMID: 7844497

Clinical prediction guides

Synthetic Simulator for Surgical Training in Tracheostomy and Open Airway Surgery.
Deonarain AR, Harrison RV, Gordon KA, Looi T, Agur AMR, Estrada M, Wolter NE, Propst EJ
Laryngoscope 2021 Jul;131(7):E2378-E2386. Epub 2021 Jan 16 doi: 10.1002/lary.29359. PMID: 33452681
CT-based assessment of laryngeal fracture patterns and associated soft tissue abnormality.
Buch K, Takumi K, Curtin HD, Sakai O
Eur Radiol 2021 Jul;31(7):5212-5221. Epub 2021 Jan 6 doi: 10.1007/s00330-020-07548-4. PMID: 33409785
Laryngeal Split and Rib Cartilage Interpositional Grafting: Treatment Option for Glottic and Subglottic Stenosis in Adults.
Hasan W, Gullane P
Thorac Surg Clin 2018 May;28(2):189-197. doi: 10.1016/j.thorsurg.2018.01.013. PMID: 29627053
Ankyloglossia with deviation of the epiglottis and larynx.
Mukai S, Mukai C, Asaoka K
Ann Otol Rhinol Laryngol Suppl 1991 May;153:3-20. doi: 10.1177/00034894911000s501. PMID: 2024905
Contemporary surgical management of laryngeal stenosis in children.
Cotton RT, Myer CM 3rd
Am J Otolaryngol 1984 Sep-Oct;5(5):360-8. doi: 10.1016/s0196-0709(84)80006-x. PMID: 6388386

Recent systematic reviews

Systematic review of pediatric postcricoid cushion and postcricoid lesions.
Lee A, Patel NA
Int J Pediatr Otorhinolaryngol 2022 Nov;162:111293. Epub 2022 Aug 27 doi: 10.1016/j.ijporl.2022.111293. PMID: 36044795
The groningen laryngomalacia classification system--based on systematic review and dynamic airway changes.
van der Heijden M, Dikkers FG, Halmos GB
Pediatr Pulmonol 2015 Dec;50(12):1368-73. Epub 2015 Mar 30 doi: 10.1002/ppul.23186. PMID: 25825153

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...