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Abnormal number of vertebrae

MedGen UID:
868132
•Concept ID:
C4022523
•
Anatomical Abnormality
HPO: HP:0030304

Definition

A deviation from the normal number of vertebrae in the spinal column. [from HPO]

Professional guidelines

PubMed

Klippel-Feil Syndrome: Pathogenesis, Diagnosis, and Management.
Litrenta J, Bi AS, Dryer JW
J Am Acad Orthop Surg 2021 Nov 15;29(22):951-960. doi: 10.5435/JAAOS-D-21-00190. PMID: 34288888
Levodopa treatment and dendritic spine pathology.
Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414Free PMC Article
Early-onset scoliosis: current treatment.
Cunin V
Orthop Traumatol Surg Res 2015 Feb;101(1 Suppl):S109-18. Epub 2015 Jan 23 doi: 10.1016/j.otsr.2014.06.032. PMID: 25623270

Recent clinical studies

Etiology

Do mobility exercises in different environments have different effects in ankylosing spondylitis?
Gurpinar B, Ilcin N, Savci S, Akkoc N
Acta Reumatol Port 2021 Oct-Dec;46(4):297-316. PMID: 34962245
Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration.
Krut Z, Pelled G, Gazit D, Gazit Z
Cells 2021 Aug 29;10(9) doi: 10.3390/cells10092241. PMID: 34571890Free PMC Article
Effectiveness of pediatric integrative manual therapy in cervical movement limitation in infants with positional plagiocephaly: a randomized controlled trial.
Pastor-Pons I, Hidalgo-García C, Lucha-López MO, Barrau-Lalmolda M, Rodes-Pastor I, Rodríguez-Fernández ÁL, Tricás-Moreno JM
Ital J Pediatr 2021 Feb 25;47(1):41. doi: 10.1186/s13052-021-00995-9. PMID: 33632268Free PMC Article
Red flags of low back pain.
DePalma MG
JAAPA 2020 Aug;33(8):8-11. doi: 10.1097/01.JAA.0000684112.91641.4c. PMID: 32740106
Lumbar lordosis.
Been E, Kalichman L
Spine J 2014 Jan;14(1):87-97. Epub 2013 Oct 2 doi: 10.1016/j.spinee.2013.07.464. PMID: 24095099

Diagnosis

Klippel-Feil Syndrome: Pathogenesis, Diagnosis, and Management.
Litrenta J, Bi AS, Dryer JW
J Am Acad Orthop Surg 2021 Nov 15;29(22):951-960. doi: 10.5435/JAAOS-D-21-00190. PMID: 34288888
Red flags of low back pain.
DePalma MG
JAAPA 2020 Aug;33(8):8-11. doi: 10.1097/01.JAA.0000684112.91641.4c. PMID: 32740106
Gorlin-Goltz syndrome.
Bartoš V, Kullová M, Adamicová K, Paučinová I
Klin Onkol 2019 Spring;32(2):124-128. doi: 10.14735/amko2019124. PMID: 30995852
Thoracic Insufficiency Syndrome.
Mayer O, Campbell R, Cahill P, Redding G
Curr Probl Pediatr Adolesc Health Care 2016 Mar;46(3):72-97. Epub 2015 Dec 30 doi: 10.1016/j.cppeds.2015.11.001. PMID: 26747620
Primary Osteoporosis.
Arundel P, Bishop N
Endocr Dev 2015;28:162-175. Epub 2015 Jun 12 doi: 10.1159/000381037. PMID: 26138841

Therapy

Do mobility exercises in different environments have different effects in ankylosing spondylitis?
Gurpinar B, Ilcin N, Savci S, Akkoc N
Acta Reumatol Port 2021 Oct-Dec;46(4):297-316. PMID: 34962245
Effectiveness of pediatric integrative manual therapy in cervical movement limitation in infants with positional plagiocephaly: a randomized controlled trial.
Pastor-Pons I, Hidalgo-García C, Lucha-López MO, Barrau-Lalmolda M, Rodes-Pastor I, Rodríguez-Fernández ÁL, Tricás-Moreno JM
Ital J Pediatr 2021 Feb 25;47(1):41. doi: 10.1186/s13052-021-00995-9. PMID: 33632268Free PMC Article
Red flags of low back pain.
DePalma MG
JAAPA 2020 Aug;33(8):8-11. doi: 10.1097/01.JAA.0000684112.91641.4c. PMID: 32740106
Hypertonic Saline is Superior to Mannitol for the Combined Effect on Intracranial Pressure and Cerebral Perfusion Pressure Burdens in Patients With Severe Traumatic Brain Injury.
Mangat HS, Wu X, Gerber LM, Schwarz JT, Fakhar M, Murthy SB, Stieg PE, Ghajar J, Härtl R
Neurosurgery 2020 Feb 1;86(2):221-230. doi: 10.1093/neuros/nyz046. PMID: 30877299Free PMC Article
Bisphosphonate therapy for osteogenesis imperfecta.
Dwan K, Phillipi CA, Steiner RD, Basel D
Cochrane Database Syst Rev 2016 Oct 19;10(10):CD005088. doi: 10.1002/14651858.CD005088.pub4. PMID: 27760454Free PMC Article

Prognosis

Effectiveness of pediatric integrative manual therapy in cervical movement limitation in infants with positional plagiocephaly: a randomized controlled trial.
Pastor-Pons I, Hidalgo-García C, Lucha-López MO, Barrau-Lalmolda M, Rodes-Pastor I, Rodríguez-Fernández ÁL, Tricás-Moreno JM
Ital J Pediatr 2021 Feb 25;47(1):41. doi: 10.1186/s13052-021-00995-9. PMID: 33632268Free PMC Article
Gaucher Disease in Bone: From Pathophysiology to Practice.
Hughes D, Mikosch P, Belmatoug N, Carubbi F, Cox T, Goker-Alpan O, Kindmark A, Mistry P, Poll L, Weinreb N, Deegan P
J Bone Miner Res 2019 Jun;34(6):996-1013. Epub 2019 Jun 24 doi: 10.1002/jbmr.3734. PMID: 31233632Free PMC Article
Gorlin-Goltz syndrome.
Bartoš V, Kullová M, Adamicová K, Paučinová I
Klin Onkol 2019 Spring;32(2):124-128. doi: 10.14735/amko2019124. PMID: 30995852
Perioperative Nutritional Optimization in Spine Surgery.
Qureshi R, Rasool M, Puvanesarajah V, Hassanzadeh H
Clin Spine Surg 2018 Apr;31(3):103-107. doi: 10.1097/BSD.0000000000000579. PMID: 29596212
Pediatric neurosonography.
Grant EG, White EM
J Child Neurol 1986 Oct;1(4):319-37. doi: 10.1177/088307388600100403. PMID: 3298401

Clinical prediction guides

Klippel-Feil Syndrome: Pathogenesis, Diagnosis, and Management.
Litrenta J, Bi AS, Dryer JW
J Am Acad Orthop Surg 2021 Nov 15;29(22):951-960. doi: 10.5435/JAAOS-D-21-00190. PMID: 34288888
Hypertonic Saline is Superior to Mannitol for the Combined Effect on Intracranial Pressure and Cerebral Perfusion Pressure Burdens in Patients With Severe Traumatic Brain Injury.
Mangat HS, Wu X, Gerber LM, Schwarz JT, Fakhar M, Murthy SB, Stieg PE, Ghajar J, Härtl R
Neurosurgery 2020 Feb 1;86(2):221-230. doi: 10.1093/neuros/nyz046. PMID: 30877299Free PMC Article
Gaucher Disease in Bone: From Pathophysiology to Practice.
Hughes D, Mikosch P, Belmatoug N, Carubbi F, Cox T, Goker-Alpan O, Kindmark A, Mistry P, Poll L, Weinreb N, Deegan P
J Bone Miner Res 2019 Jun;34(6):996-1013. Epub 2019 Jun 24 doi: 10.1002/jbmr.3734. PMID: 31233632Free PMC Article
Perioperative Nutritional Optimization in Spine Surgery.
Qureshi R, Rasool M, Puvanesarajah V, Hassanzadeh H
Clin Spine Surg 2018 Apr;31(3):103-107. doi: 10.1097/BSD.0000000000000579. PMID: 29596212
Bisphosphonate therapy for osteogenesis imperfecta.
Dwan K, Phillipi CA, Steiner RD, Basel D
Cochrane Database Syst Rev 2016 Oct 19;10(10):CD005088. doi: 10.1002/14651858.CD005088.pub4. PMID: 27760454Free PMC Article

Recent systematic reviews

Comparison of ultrasound-guided and traditional localisation in intraspinal anesthesia: a systematic review and network meta-analysis.
Zhang Y, Peng M, Wei J, Huang J, Ma W, Li Y
BMJ Open 2023 Nov 2;13(11):e071253. doi: 10.1136/bmjopen-2022-071253. PMID: 37918920Free PMC Article
Incidence of cardiac anomalies in congenital vertebral deformity: systematic review and meta-analysis of 2910 patients.
Bas JL, Pérez S, Rubio P, Mariscal G, Bonilla F, Bovea M, Bas P, Bas T
Eur Spine J 2023 Sep;32(9):2967-2974. Epub 2023 Jun 9 doi: 10.1007/s00586-023-07817-y. PMID: 37294359
Vertebral anomalies in craniofacial microsomia: a systematic review.
Renkema RW, Caron CJJM, Mathijssen IMJ, Wolvius EB, Dunaway DJ, Forrest CR, Padwa BL, Koudstaal MJ
Int J Oral Maxillofac Surg 2017 Oct;46(10):1319-1329. Epub 2017 Jun 29 doi: 10.1016/j.ijom.2017.04.025. PMID: 28669484
Adverse Fetal and Neonatal Outcome and an Abnormal Vertebral Pattern: A Systematic Review.
Schut PC, Cohen-Overbeek TE, Galis F, Ten Broek CM, Steegers EA, Eggink AJ
Obstet Gynecol Surv 2016 Dec;71(12):741-750. doi: 10.1097/OGX.0000000000000388. PMID: 28005137
Bisphosphonate therapy for osteogenesis imperfecta.
Dwan K, Phillipi CA, Steiner RD, Basel D
Cochrane Database Syst Rev 2016 Oct 19;10(10):CD005088. doi: 10.1002/14651858.CD005088.pub4. PMID: 27760454Free PMC Article

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