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Fatigable weakness of chewing muscles

MedGen UID:
868198
•Concept ID:
C4022590
•
Finding
HPO: HP:0030193

Definition

A type of weakness of the muscles involved in chewing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFatigable weakness of chewing muscles

Recent clinical studies

Etiology

Sarcopenia of the longitudinal tongue muscles in rats.
Sieck GC, Hernandez-Vizcarrondo GA, Brown AD, Fogarty MJ
Respir Physiol Neurobiol 2024 Jan;319:104180. Epub 2023 Oct 18 doi: 10.1016/j.resp.2023.104180. PMID: 37863156Free PMC Article
New compound heterozygous variants of the cholinergic receptor nicotinic delta subunit gene in a Chinese male with congenital myasthenic syndrome: A case report.
Feng H, Zhou H
Medicine (Baltimore) 2017 Dec;96(51):e8981. doi: 10.1097/MD.0000000000008981. PMID: 29390429Free PMC Article
Myasthenic syndrome of snake envenomation: a clinical and neurophysiological study.
Sanmuganathan PS
Postgrad Med J 1998 Oct;74(876):596-9. doi: 10.1136/pgmj.74.876.596. PMID: 10211352Free PMC Article

Diagnosis

New compound heterozygous variants of the cholinergic receptor nicotinic delta subunit gene in a Chinese male with congenital myasthenic syndrome: A case report.
Feng H, Zhou H
Medicine (Baltimore) 2017 Dec;96(51):e8981. doi: 10.1097/MD.0000000000008981. PMID: 29390429Free PMC Article
Childhood-onset myasthenia gravis with thymoma.
Nikolic DM, Nikolic AV, Lavrnic DV, Medjo BP, Ivanovski PI
Pediatr Neurol 2012 May;46(5):329-31. doi: 10.1016/j.pediatrneurol.2012.02.025. PMID: 22520357

Prognosis

Childhood-onset myasthenia gravis with thymoma.
Nikolic DM, Nikolic AV, Lavrnic DV, Medjo BP, Ivanovski PI
Pediatr Neurol 2012 May;46(5):329-31. doi: 10.1016/j.pediatrneurol.2012.02.025. PMID: 22520357

Clinical prediction guides

Sarcopenia of the longitudinal tongue muscles in rats.
Sieck GC, Hernandez-Vizcarrondo GA, Brown AD, Fogarty MJ
Respir Physiol Neurobiol 2024 Jan;319:104180. Epub 2023 Oct 18 doi: 10.1016/j.resp.2023.104180. PMID: 37863156Free PMC Article

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