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Decreased female libido

MedGen UID:
868284
•Concept ID:
C4022676
•
Finding
Synonym: Decreased female sex drive
 
HPO: HP:0030018

Definition

Diminished sexual desire in female. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased female libido

Professional guidelines

PubMed

The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review.
Uloko M, Rahman F, Puri LI, Rubin RS
Int J Impot Res 2022 Nov;34(7):635-641. Epub 2022 Oct 5 doi: 10.1038/s41443-022-00613-0. PMID: 36198811Free PMC Article
Supplementation of dehydroepiandrosterone (DHEA) in pre- and postmenopausal women - position statement of expert panel of Polish Menopause and Andropause Society.
Rabijewski M, Papierska L, Binkowska M, Maksym R, Jankowska K, Skrzypulec-Plinta W, Zgliczynski W
Ginekol Pol 2020;91(9):554-562. doi: 10.5603/GP.2020.0091. PMID: 33030737
Female sexual dysfunction: anatomy, physiology, evaluation and treatment options.
Berman JR, Berman LA, Werbin TJ, Goldstein I
Curr Opin Urol 1999 Nov;9(6):563-8. doi: 10.1097/00042307-199911000-00012. PMID: 10668578

Recent clinical studies

Etiology

The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review.
Uloko M, Rahman F, Puri LI, Rubin RS
Int J Impot Res 2022 Nov;34(7):635-641. Epub 2022 Oct 5 doi: 10.1038/s41443-022-00613-0. PMID: 36198811Free PMC Article
Symptoms and risk factors for long COVID in non-hospitalized adults.
Subramanian A, Nirantharakumar K, Hughes S, Myles P, Williams T, Gokhale KM, Taverner T, Chandan JS, Brown K, Simms-Williams N, Shah AD, Singh M, Kidy F, Okoth K, Hotham R, Bashir N, Cockburn N, Lee SI, Turner GM, Gkoutos GV, Aiyegbusi OL, McMullan C, Denniston AK, Sapey E, Lord JM, Wraith DC, Leggett E, Iles C, Marshall T, Price MJ, Marwaha S, Davies EH, Jackson LJ, Matthews KL, Camaradou J, Calvert M, Haroon S
Nat Med 2022 Aug;28(8):1706-1714. Epub 2022 Jul 25 doi: 10.1038/s41591-022-01909-w. PMID: 35879616Free PMC Article
Finasteride for hair loss: a review.
Gupta AK, Venkataraman M, Talukder M, Bamimore MA
J Dermatolog Treat 2022 Jun;33(4):1938-1946. Epub 2021 Aug 2 doi: 10.1080/09546634.2021.1959506. PMID: 34291720
Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
Sletten TL, Magee M, Murray JM, Gordon CJ, Lovato N, Kennaway DJ, Gwini SM, Bartlett DJ, Lockley SW, Lack LC, Grunstein RR, Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group
PLoS Med 2018 Jun;15(6):e1002587. Epub 2018 Jun 18 doi: 10.1371/journal.pmed.1002587. PMID: 29912983Free PMC Article
Selective serotonin reuptake inhibitors for premenstrual syndrome.
Marjoribanks J, Brown J, O'Brien PM, Wyatt K
Cochrane Database Syst Rev 2013 Jun 7;2013(6):CD001396. doi: 10.1002/14651858.CD001396.pub3. PMID: 23744611Free PMC Article

Diagnosis

The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review.
Uloko M, Rahman F, Puri LI, Rubin RS
Int J Impot Res 2022 Nov;34(7):635-641. Epub 2022 Oct 5 doi: 10.1038/s41443-022-00613-0. PMID: 36198811Free PMC Article
Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
Sletten TL, Magee M, Murray JM, Gordon CJ, Lovato N, Kennaway DJ, Gwini SM, Bartlett DJ, Lockley SW, Lack LC, Grunstein RR, Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group
PLoS Med 2018 Jun;15(6):e1002587. Epub 2018 Jun 18 doi: 10.1371/journal.pmed.1002587. PMID: 29912983Free PMC Article
Sexual Consequences of Post-SSRI Syndrome.
Reisman Y
Sex Med Rev 2017 Oct;5(4):429-433. Epub 2017 Jun 20 doi: 10.1016/j.sxmr.2017.05.002. PMID: 28642048
Hypoactive Sexual Desire Disorder: International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel Review.
Goldstein I, Kim NN, Clayton AH, DeRogatis LR, Giraldi A, Parish SJ, Pfaus J, Simon JA, Kingsberg SA, Meston C, Stahl SM, Wallen K, Worsley R
Mayo Clin Proc 2017 Jan;92(1):114-128. Epub 2016 Dec 1 doi: 10.1016/j.mayocp.2016.09.018. PMID: 27916394
Selective serotonin reuptake inhibitors for premenstrual syndrome.
Marjoribanks J, Brown J, O'Brien PM, Wyatt K
Cochrane Database Syst Rev 2013 Jun 7;2013(6):CD001396. doi: 10.1002/14651858.CD001396.pub3. PMID: 23744611Free PMC Article

Therapy

The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review.
Uloko M, Rahman F, Puri LI, Rubin RS
Int J Impot Res 2022 Nov;34(7):635-641. Epub 2022 Oct 5 doi: 10.1038/s41443-022-00613-0. PMID: 36198811Free PMC Article
Finasteride for hair loss: a review.
Gupta AK, Venkataraman M, Talukder M, Bamimore MA
J Dermatolog Treat 2022 Jun;33(4):1938-1946. Epub 2021 Aug 2 doi: 10.1080/09546634.2021.1959506. PMID: 34291720
Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
Sletten TL, Magee M, Murray JM, Gordon CJ, Lovato N, Kennaway DJ, Gwini SM, Bartlett DJ, Lockley SW, Lack LC, Grunstein RR, Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group
PLoS Med 2018 Jun;15(6):e1002587. Epub 2018 Jun 18 doi: 10.1371/journal.pmed.1002587. PMID: 29912983Free PMC Article
Hypoactive Sexual Desire Disorder: International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel Review.
Goldstein I, Kim NN, Clayton AH, DeRogatis LR, Giraldi A, Parish SJ, Pfaus J, Simon JA, Kingsberg SA, Meston C, Stahl SM, Wallen K, Worsley R
Mayo Clin Proc 2017 Jan;92(1):114-128. Epub 2016 Dec 1 doi: 10.1016/j.mayocp.2016.09.018. PMID: 27916394
Selective serotonin reuptake inhibitors for premenstrual syndrome.
Marjoribanks J, Brown J, O'Brien PM, Wyatt K
Cochrane Database Syst Rev 2013 Jun 7;2013(6):CD001396. doi: 10.1002/14651858.CD001396.pub3. PMID: 23744611Free PMC Article

Prognosis

Splenectomy is associated with sexual dysfunctions and decreased libido.
Sabino KR, Petroianu A
Sci Rep 2021 Nov 5;11(1):21770. doi: 10.1038/s41598-021-01371-7. PMID: 34741128Free PMC Article
Amitriptyline and Sexual Function: A Systematic Review Updated for Sexual Health Practice.
Chen LW, Chen MY, Lian ZP, Lin HS, Chien CC, Yin HL, Chu YH, Chen KY
Am J Mens Health 2018 Mar;12(2):370-379. Epub 2017 Oct 11 doi: 10.1177/1557988317734519. PMID: 29019272Free PMC Article
Female sexual function and response.
Arcos B
J Am Osteopath Assoc 2004 Jan;104(1 Suppl 1):S16-20. PMID: 14992322
Safety of estrogen/androgen regimens.
Simon JA
J Reprod Med 2001 Mar;46(3 Suppl):281-90. PMID: 11304876
Sexual dysfunction in uremia.
Palmer BF
J Am Soc Nephrol 1999 Jun;10(6):1381-8. doi: 10.1681/ASN.V1061381. PMID: 10361878

Clinical prediction guides

Symptoms and risk factors for long COVID in non-hospitalized adults.
Subramanian A, Nirantharakumar K, Hughes S, Myles P, Williams T, Gokhale KM, Taverner T, Chandan JS, Brown K, Simms-Williams N, Shah AD, Singh M, Kidy F, Okoth K, Hotham R, Bashir N, Cockburn N, Lee SI, Turner GM, Gkoutos GV, Aiyegbusi OL, McMullan C, Denniston AK, Sapey E, Lord JM, Wraith DC, Leggett E, Iles C, Marshall T, Price MJ, Marwaha S, Davies EH, Jackson LJ, Matthews KL, Camaradou J, Calvert M, Haroon S
Nat Med 2022 Aug;28(8):1706-1714. Epub 2022 Jul 25 doi: 10.1038/s41591-022-01909-w. PMID: 35879616Free PMC Article
Splenectomy is associated with sexual dysfunctions and decreased libido.
Sabino KR, Petroianu A
Sci Rep 2021 Nov 5;11(1):21770. doi: 10.1038/s41598-021-01371-7. PMID: 34741128Free PMC Article
Amitriptyline and Sexual Function: A Systematic Review Updated for Sexual Health Practice.
Chen LW, Chen MY, Lian ZP, Lin HS, Chien CC, Yin HL, Chu YH, Chen KY
Am J Mens Health 2018 Mar;12(2):370-379. Epub 2017 Oct 11 doi: 10.1177/1557988317734519. PMID: 29019272Free PMC Article
Selective serotonin reuptake inhibitors for premenstrual syndrome.
Marjoribanks J, Brown J, O'Brien PM, Wyatt K
Cochrane Database Syst Rev 2013 Jun 7;2013(6):CD001396. doi: 10.1002/14651858.CD001396.pub3. PMID: 23744611Free PMC Article
Androgen in postmenopausal women.
Yasui T, Matsui S, Tani A, Kunimi K, Yamamoto S, Irahara M
J Med Invest 2012;59(1-2):12-27. doi: 10.2152/jmi.59.12. PMID: 22449989

Recent systematic reviews

Erectile and Ejaculatory Dysfunction Associated with Use of Psychotropic Drugs: A Systematic Review.
Trinchieri M, Trinchieri M, Perletti G, Magri V, Stamatiou K, Cai T, Montanari E, Trinchieri A
J Sex Med 2021 Aug;18(8):1354-1363. Epub 2021 Jul 8 doi: 10.1016/j.jsxm.2021.05.016. PMID: 34247952
Amitriptyline and Sexual Function: A Systematic Review Updated for Sexual Health Practice.
Chen LW, Chen MY, Lian ZP, Lin HS, Chien CC, Yin HL, Chu YH, Chen KY
Am J Mens Health 2018 Mar;12(2):370-379. Epub 2017 Oct 11 doi: 10.1177/1557988317734519. PMID: 29019272Free PMC Article
Determinants of sexual function and dysfunction in men and women with stroke: A systematic review.
Dusenbury W, Palm Johansen P, Mosack V, Steinke EE
Int J Clin Pract 2017 Jul;71(7) Epub 2017 Jun 8 doi: 10.1111/ijcp.12969. PMID: 28594462
Selective serotonin reuptake inhibitors for premenstrual syndrome.
Marjoribanks J, Brown J, O'Brien PM, Wyatt K
Cochrane Database Syst Rev 2013 Jun 7;2013(6):CD001396. doi: 10.1002/14651858.CD001396.pub3. PMID: 23744611Free PMC Article
A systematic review of sexual concerns reported by gynecological cancer survivors.
Abbott-Anderson K, Kwekkeboom KL
Gynecol Oncol 2012 Mar;124(3):477-89. Epub 2011 Nov 28 doi: 10.1016/j.ygyno.2011.11.030. PMID: 22134375

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