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Focal T2 hypointense brainstem lesion

MedGen UID:
868353
•Concept ID:
C4022747
•
Finding
HPO: HP:0012749

Definition

A darker than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a localized hypointensity affecting a particular region of the brainstem. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal T2 hypointense brainstem lesion

Professional guidelines

PubMed

Skull base erosion by sphenoid fungus balls: diagnosis and endoscopic treatment.
Schlosser RJ, Gross CW, Kountakis S
Am J Rhinol 2002 May-Jun;16(3):161-4. PMID: 12141774
The management of brainstem gliomas in patients with neurofibromatosis 1.
Pollack IF, Shultz B, Mulvihill JJ
Neurology 1996 Jun;46(6):1652-60. doi: 10.1212/wnl.46.6.1652. PMID: 8649565

Recent clinical studies

Etiology

Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma.
Löbel U, Sedlacik J, Reddick WE, Kocak M, Ji Q, Broniscer A, Hillenbrand CM, Patay Z
AJNR Am J Neuroradiol 2011 Feb;32(2):315-22. Epub 2010 Nov 18 doi: 10.3174/ajnr.A2277. PMID: 21087935Free PMC Article
CT and MR imaging characteristics of intravestibular lipoma.
Dahlen RT, Johnson CE, Harnsberger HR, Biediger CP, Syms CA, Fischbein NJ, Schwartz JM
AJNR Am J Neuroradiol 2002 Sep;23(8):1413-7. PMID: 12223388Free PMC Article
Globular glioma of the tectum.
Antunes NL, Tavora L, Souweidane M
Pediatr Neurol 1999 Jul;21(1):492-5. doi: 10.1016/s0887-8994(99)00009-0. PMID: 10428437
Multifocal hypointense cerebral lesions on gradient-echo MR are associated with chronic hypertension.
Chan S, Kartha K, Yoon SS, Desmond DW, Hilal SK
AJNR Am J Neuroradiol 1996 Nov-Dec;17(10):1821-7. PMID: 8933864Free PMC Article
The management of brainstem gliomas in patients with neurofibromatosis 1.
Pollack IF, Shultz B, Mulvihill JJ
Neurology 1996 Jun;46(6):1652-60. doi: 10.1212/wnl.46.6.1652. PMID: 8649565

Diagnosis

An atypical presentation of primary central nervous system lymphoma: A case report.
Yuen CA, Mastrianni J, Ali S, Pytel P, Park DM, Rezania K
Medicine (Baltimore) 2020 Sep 18;99(38):e22062. doi: 10.1097/MD.0000000000022062. PMID: 32957327Free PMC Article
Intracranial melanotic schwannomas: a rare variant with unusual adherent features.
Mahato D, Vivas-Buitrago T, Gassie K, Jentoft M, Tavanaiepour D, Quiñones-Hinojosa A
J Neurooncol 2018 Jan;136(2):299-306. Epub 2017 Nov 2 doi: 10.1007/s11060-017-2653-z. PMID: 29098570
Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it?
Öğrenci A, Batçık OE, Ekşi MŞ, Koban O
Childs Nerv Syst 2016 Aug;32(8):1513-6. Epub 2015 Dec 12 doi: 10.1007/s00381-015-2982-1. PMID: 26661575
Globular glioma of the tectum.
Antunes NL, Tavora L, Souweidane M
Pediatr Neurol 1999 Jul;21(1):492-5. doi: 10.1016/s0887-8994(99)00009-0. PMID: 10428437
Quantitative volumetric analysis of brain magnetic resonance imaging from patients with multiple sclerosis.
Filippi M, Mastronardo G, Rocca MA, Pereira C, Comi G
J Neurol Sci 1998 Jun 30;158(2):148-53. doi: 10.1016/s0022-510x(98)00110-5. PMID: 9702685

Therapy

An atypical presentation of primary central nervous system lymphoma: A case report.
Yuen CA, Mastrianni J, Ali S, Pytel P, Park DM, Rezania K
Medicine (Baltimore) 2020 Sep 18;99(38):e22062. doi: 10.1097/MD.0000000000022062. PMID: 32957327Free PMC Article

Prognosis

Intracranial melanotic schwannomas: a rare variant with unusual adherent features.
Mahato D, Vivas-Buitrago T, Gassie K, Jentoft M, Tavanaiepour D, Quiñones-Hinojosa A
J Neurooncol 2018 Jan;136(2):299-306. Epub 2017 Nov 2 doi: 10.1007/s11060-017-2653-z. PMID: 29098570
Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it?
Öğrenci A, Batçık OE, Ekşi MŞ, Koban O
Childs Nerv Syst 2016 Aug;32(8):1513-6. Epub 2015 Dec 12 doi: 10.1007/s00381-015-2982-1. PMID: 26661575
Dorsal brain stem syndrome: MR imaging location of brain stem tegmental lesions in neonates with oral motor dysfunction.
Quattrocchi CC, Longo D, Delfino LN, Cilio MR, Piersigilli F, Capua MD, Seganti G, Danhaive O, Fariello G
AJNR Am J Neuroradiol 2010 Sep;31(8):1438-42. Epub 2010 Apr 15 doi: 10.3174/ajnr.A2103. PMID: 20395394Free PMC Article
Globular glioma of the tectum.
Antunes NL, Tavora L, Souweidane M
Pediatr Neurol 1999 Jul;21(1):492-5. doi: 10.1016/s0887-8994(99)00009-0. PMID: 10428437
The management of brainstem gliomas in patients with neurofibromatosis 1.
Pollack IF, Shultz B, Mulvihill JJ
Neurology 1996 Jun;46(6):1652-60. doi: 10.1212/wnl.46.6.1652. PMID: 8649565

Clinical prediction guides

Quantitative volumetric analysis of brain magnetic resonance imaging from patients with multiple sclerosis.
Filippi M, Mastronardo G, Rocca MA, Pereira C, Comi G
J Neurol Sci 1998 Jun 30;158(2):148-53. doi: 10.1016/s0022-510x(98)00110-5. PMID: 9702685

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