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Focal T2 hyperintense brainstem lesion

MedGen UID:
868354
Concept ID:
C4022748
Finding
HPO: HP:0012748

Definition

A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a localized hyperintensity affecting a particular region of the brainstem. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal T2 hyperintense brainstem lesion

Professional guidelines

PubMed

Guzmán-De-Villoria JA, Fernández-García P, Ferreiro-Argüelles C
Semin Ultrasound CT MR 2010 Jun;31(3):246-59. doi: 10.1053/j.sult.2010.03.001. PMID: 20483392
Dağlioğlu E, Cataltepe O, Akalan N
Pediatr Neurosurg 2003 May;38(5):223-31. doi: 10.1159/000069823. PMID: 12686764
Pollack IF, Shultz B, Mulvihill JJ
Neurology 1996 Jun;46(6):1652-60. doi: 10.1212/wnl.46.6.1652. PMID: 8649565

Recent clinical studies

Etiology

Song X, Ma J
Front Immunol 2022;13:1050688. Epub 2022 Dec 1 doi: 10.3389/fimmu.2022.1050688. PMID: 36532000Free PMC Article
Roosendaal SD, van de Brug T, Alves CAPF, Blaser S, Vanderver A, Wolf NI, van der Knaap MS
AJNR Am J Neuroradiol 2021 Jul;42(7):1334-1340. Epub 2021 Apr 1 doi: 10.3174/ajnr.A7097. PMID: 34255734Free PMC Article
Kim E, Na DG, Kim EY, Kim JH, Son KR, Chang KH
AJNR Am J Neuroradiol 2007 Oct;28(9):1652-8. Epub 2007 Sep 20 doi: 10.3174/ajnr.A0655. PMID: 17885234Free PMC Article
Gill DS, Hyman SL, Steinberg A, North KN
Pediatr Radiol 2006 Oct;36(10):1048-56. Epub 2006 Aug 16 doi: 10.1007/s00247-006-0267-2. PMID: 16912896
Pollack IF, Shultz B, Mulvihill JJ
Neurology 1996 Jun;46(6):1652-60. doi: 10.1212/wnl.46.6.1652. PMID: 8649565

Diagnosis

Ingrasci G, Tornes L, Brown A, Delgado S, Hernandez J, Yap QV, Yosipovitch G
J Eur Acad Dermatol Venereol 2023 Jan;37(1):154-159. Epub 2022 Sep 13 doi: 10.1111/jdv.18561. PMID: 36017740
Roosendaal SD, van de Brug T, Alves CAPF, Blaser S, Vanderver A, Wolf NI, van der Knaap MS
AJNR Am J Neuroradiol 2021 Jul;42(7):1334-1340. Epub 2021 Apr 1 doi: 10.3174/ajnr.A7097. PMID: 34255734Free PMC Article
Mahato D, Vivas-Buitrago T, Gassie K, Jentoft M, Tavanaiepour D, Quiñones-Hinojosa A
J Neurooncol 2018 Jan;136(2):299-306. Epub 2017 Nov 2 doi: 10.1007/s11060-017-2653-z. PMID: 29098570
Guzmán-De-Villoria JA, Fernández-García P, Ferreiro-Argüelles C
Semin Ultrasound CT MR 2010 Jun;31(3):246-59. doi: 10.1053/j.sult.2010.03.001. PMID: 20483392
Garg RK
Postgrad Med J 2001 Jan;77(903):24-8. doi: 10.1136/pmj.77.903.24. PMID: 11123390Free PMC Article

Therapy

Yuen CA, Mastrianni J, Ali S, Pytel P, Park DM, Rezania K
Medicine (Baltimore) 2020 Sep 18;99(38):e22062. doi: 10.1097/MD.0000000000022062. PMID: 32957327Free PMC Article
Kuhnt D, Becker A, Benes L, Nimsky C
J Neurol Surg A Cent Eur Neurosurg 2013 Dec;74 Suppl 1:e128-32. Epub 2012 Oct 5 doi: 10.1055/s-0032-1327448. PMID: 23042139
Ii Y, Shindo A, Sasaki R, Naito Y, Tanaka K, Kuzuhara S
Rheumatol Int 2008 Oct;28(12):1277-80. Epub 2008 May 21 doi: 10.1007/s00296-008-0611-y. PMID: 18493764
Kim E, Na DG, Kim EY, Kim JH, Son KR, Chang KH
AJNR Am J Neuroradiol 2007 Oct;28(9):1652-8. Epub 2007 Sep 20 doi: 10.3174/ajnr.A0655. PMID: 17885234Free PMC Article
Dichgans M, Holtmannspötter M, Herzog J, Peters N, Bergmann M, Yousry TA
Stroke 2002 Jan;33(1):67-71. doi: 10.1161/hs0102.100885. PMID: 11779891

Prognosis

Lim XY, Wai YZ, Yong YX, Lim LT
J Med Case Rep 2023 Mar 6;17(1):99. doi: 10.1186/s13256-022-03699-8. PMID: 36879252Free PMC Article
Koh YH, Ratnagopal P
Mult Scler Relat Disord 2020 Oct;45:102348. Epub 2020 Jul 1 doi: 10.1016/j.msard.2020.102348. PMID: 32623365
Mahato D, Vivas-Buitrago T, Gassie K, Jentoft M, Tavanaiepour D, Quiñones-Hinojosa A
J Neurooncol 2018 Jan;136(2):299-306. Epub 2017 Nov 2 doi: 10.1007/s11060-017-2653-z. PMID: 29098570
Schoenen J, De Leval L, Reznik M
Acta Neurol Belg 1996 Dec;96(4):294-300. PMID: 9008778
Pollack IF, Shultz B, Mulvihill JJ
Neurology 1996 Jun;46(6):1652-60. doi: 10.1212/wnl.46.6.1652. PMID: 8649565

Clinical prediction guides

Song X, Ma J
Front Immunol 2022;13:1050688. Epub 2022 Dec 1 doi: 10.3389/fimmu.2022.1050688. PMID: 36532000Free PMC Article
Lui A, Chong J, Flanagan E, Abrams AW, Krysko KM, Arikan B, Francisco C, Rutatangwa A, Waubant E, Ziaei A
Mult Scler Relat Disord 2021 Nov;56:103253. Epub 2021 Sep 4 doi: 10.1016/j.msard.2021.103253. PMID: 34517190Free PMC Article
Xia NG, Chen YY, Li J, Chen X, Ye ZS, Chen SY, Zhu ZG
Int J Neurosci 2018 Aug;128(8):746-750. Epub 2017 Dec 29 doi: 10.1080/00207454.2017.1418344. PMID: 29243534
Kevelam SH, Bugiani M, Salomons GS, Feigenbaum A, Blaser S, Prasad C, Häberle J, Baric I, Bakker IM, Postma NL, Kanhai WA, Wolf NI, Abbink TE, Waisfisz Q, Heutink P, van der Knaap MS
Brain 2013 May;136(Pt 5):1534-43. Epub 2013 Mar 12 doi: 10.1093/brain/awt054. PMID: 23482991
Dichgans M, Holtmannspötter M, Herzog J, Peters N, Bergmann M, Yousry TA
Stroke 2002 Jan;33(1):67-71. doi: 10.1161/hs0102.100885. PMID: 11779891

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