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Abnormal urine chloride concentration

MedGen UID:
868433
•Concept ID:
C4022827
•
Finding
Synonyms: Abnormal urine Cl concentration; Abnormal urine Cl- concentration
 
HPO: HP:0012600

Definition

An abnormal concentration of chloride in the urine. [from HPO]

Professional guidelines

PubMed

Differential diagnosis of Bartter syndrome, Gitelman syndrome, and pseudo-Bartter/Gitelman syndrome based on clinical characteristics.
Matsunoshita N, Nozu K, Shono A, Nozu Y, Fu XJ, Morisada N, Kamiyoshi N, Ohtsubo H, Ninchoji T, Minamikawa S, Yamamura T, Nakanishi K, Yoshikawa N, Shima Y, Kaito H, Iijima K
Genet Med 2016 Feb;18(2):180-8. Epub 2015 Apr 16 doi: 10.1038/gim.2015.56. PMID: 25880437
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Abnormal urine color: differential diagnosis.
Raymond JR, Yarger WE
South Med J 1988 Jul;81(7):837-41. doi: 10.1097/00007611-198807000-00008. PMID: 3393939

Recent clinical studies

Etiology

Efficacy of Potassium Supplementation in Hypokalemic Patients Receiving Peritoneal Dialysis: A Randomized Controlled Trial.
Pichitporn W, Kanjanabuch T, Phannajit J, Puapatanakul P, Chuengsaman P, Parapiboon W, Treamtrakanpon W, Boonyakrai C, Matayart S, Katavetin P, Perl J, Praditpornilpa K, Eiam-Ong S, Tungsanga K, Johnson DW
Am J Kidney Dis 2022 Nov;80(5):580-588.e1. Epub 2022 May 18 doi: 10.1053/j.ajkd.2022.03.013. PMID: 35597332
Efficacy of Furosemide, Oral Sodium Chloride, and Fluid Restriction for Treatment of Syndrome of Inappropriate Antidiuresis (SIAD): An Open-label Randomized Controlled Study (The EFFUSE-FLUID Trial).
Krisanapan P, Vongsanim S, Pin-On P, Ruengorn C, Noppakun K
Am J Kidney Dis 2020 Aug;76(2):203-212. Epub 2020 Mar 19 doi: 10.1053/j.ajkd.2019.11.012. PMID: 32199708
Tubular Acidification Defect in Adults with Sickle Cell Disease.
Cazenave M, Audard V, Bertocchio JP, Habibi A, Baron S, Prot-Bertoye C, Berkenou J, Maruani G, Stehlé T, Cornière N, Ayari H, Friedlander G, Galacteros F, Houillier P, Bartolucci P, Courbebaisse M
Clin J Am Soc Nephrol 2020 Jan 7;15(1):16-24. Epub 2019 Dec 10 doi: 10.2215/CJN.07830719. PMID: 31822527Free PMC Article
Diet and polycystic kidney disease: A pilot intervention study.
Taylor JM, Hamilton-Reeves JM, Sullivan DK, Gibson CA, Creed C, Carlson SE, Wesson DE, Grantham JJ
Clin Nutr 2017 Apr;36(2):458-466. Epub 2016 Jan 11 doi: 10.1016/j.clnu.2016.01.003. PMID: 26811129Free PMC Article
Epidemiology and clinical pathophysiology of uric acid kidney stones.
Sakhaee K
J Nephrol 2014 Jun;27(3):241-5. Epub 2014 Feb 5 doi: 10.1007/s40620-013-0034-z. PMID: 24497296Free PMC Article

Diagnosis

Tubular Acidification Defect in Adults with Sickle Cell Disease.
Cazenave M, Audard V, Bertocchio JP, Habibi A, Baron S, Prot-Bertoye C, Berkenou J, Maruani G, Stehlé T, Cornière N, Ayari H, Friedlander G, Galacteros F, Houillier P, Bartolucci P, Courbebaisse M
Clin J Am Soc Nephrol 2020 Jan 7;15(1):16-24. Epub 2019 Dec 10 doi: 10.2215/CJN.07830719. PMID: 31822527Free PMC Article
Epidemiology and clinical pathophysiology of uric acid kidney stones.
Sakhaee K
J Nephrol 2014 Jun;27(3):241-5. Epub 2014 Feb 5 doi: 10.1007/s40620-013-0034-z. PMID: 24497296Free PMC Article
Primer on clinical acid-base problem solving.
Whittier WL, Rutecki GW
Dis Mon 2004 Mar;50(3):122-62. doi: 10.1016/j.disamonth.2004.01.002. PMID: 15069420
Urine electrolytes and osmolality: when and how to use them.
Kamel KS, Ethier JH, Richardson RM, Bear RA, Halperin ML
Am J Nephrol 1990;10(2):89-102. doi: 10.1159/000168062. PMID: 2190469
Abnormal urine color: differential diagnosis.
Raymond JR, Yarger WE
South Med J 1988 Jul;81(7):837-41. doi: 10.1097/00007611-198807000-00008. PMID: 3393939

Therapy

Efficacy of Potassium Supplementation in Hypokalemic Patients Receiving Peritoneal Dialysis: A Randomized Controlled Trial.
Pichitporn W, Kanjanabuch T, Phannajit J, Puapatanakul P, Chuengsaman P, Parapiboon W, Treamtrakanpon W, Boonyakrai C, Matayart S, Katavetin P, Perl J, Praditpornilpa K, Eiam-Ong S, Tungsanga K, Johnson DW
Am J Kidney Dis 2022 Nov;80(5):580-588.e1. Epub 2022 May 18 doi: 10.1053/j.ajkd.2022.03.013. PMID: 35597332
Efficacy of Furosemide, Oral Sodium Chloride, and Fluid Restriction for Treatment of Syndrome of Inappropriate Antidiuresis (SIAD): An Open-label Randomized Controlled Study (The EFFUSE-FLUID Trial).
Krisanapan P, Vongsanim S, Pin-On P, Ruengorn C, Noppakun K
Am J Kidney Dis 2020 Aug;76(2):203-212. Epub 2020 Mar 19 doi: 10.1053/j.ajkd.2019.11.012. PMID: 32199708
Tubular Acidification Defect in Adults with Sickle Cell Disease.
Cazenave M, Audard V, Bertocchio JP, Habibi A, Baron S, Prot-Bertoye C, Berkenou J, Maruani G, Stehlé T, Cornière N, Ayari H, Friedlander G, Galacteros F, Houillier P, Bartolucci P, Courbebaisse M
Clin J Am Soc Nephrol 2020 Jan 7;15(1):16-24. Epub 2019 Dec 10 doi: 10.2215/CJN.07830719. PMID: 31822527Free PMC Article
Diet and polycystic kidney disease: A pilot intervention study.
Taylor JM, Hamilton-Reeves JM, Sullivan DK, Gibson CA, Creed C, Carlson SE, Wesson DE, Grantham JJ
Clin Nutr 2017 Apr;36(2):458-466. Epub 2016 Jan 11 doi: 10.1016/j.clnu.2016.01.003. PMID: 26811129Free PMC Article
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article

Prognosis

A machine learning approach for predicting treatment response of hyponatremia.
Kinoshita T, Oyama S, Hagiwara D, Azuma Y, Arima H
Endocr J 2024 Apr 30;71(4):345-355. Epub 2024 Mar 2 doi: 10.1507/endocrj.EJ23-0561. PMID: 38311418
Association of Renal Glomerular and Tubular Function With Renal Outcome in Patients With Posterior Urethral Valves.
Heikkilä J, Jahnukainen T, Holmberg C, Taskinen S
Urology 2021 Jul;153:285-290. Epub 2020 Dec 6 doi: 10.1016/j.urology.2020.11.045. PMID: 33296697
Epidemiology and clinical pathophysiology of uric acid kidney stones.
Sakhaee K
J Nephrol 2014 Jun;27(3):241-5. Epub 2014 Feb 5 doi: 10.1007/s40620-013-0034-z. PMID: 24497296Free PMC Article
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
The electrolytes in hyponatremia.
Graber M, Corish D
Am J Kidney Dis 1991 Nov;18(5):527-45. doi: 10.1016/s0272-6386(12)80647-0. PMID: 1835285

Clinical prediction guides

A machine learning approach for predicting treatment response of hyponatremia.
Kinoshita T, Oyama S, Hagiwara D, Azuma Y, Arima H
Endocr J 2024 Apr 30;71(4):345-355. Epub 2024 Mar 2 doi: 10.1507/endocrj.EJ23-0561. PMID: 38311418
Association of Renal Glomerular and Tubular Function With Renal Outcome in Patients With Posterior Urethral Valves.
Heikkilä J, Jahnukainen T, Holmberg C, Taskinen S
Urology 2021 Jul;153:285-290. Epub 2020 Dec 6 doi: 10.1016/j.urology.2020.11.045. PMID: 33296697
Developmental neurotoxicity of ortho-phthalate diesters: review of human and experimental evidence.
Miodovnik A, Edwards A, Bellinger DC, Hauser R
Neurotoxicology 2014 Mar;41:112-22. Epub 2014 Jan 31 doi: 10.1016/j.neuro.2014.01.007. PMID: 24486776
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Phylogenetic, ontogenetic, and pathological aspects of the urine-concentrating mechanism.
Kondo Y, Morimoto T, Nishio T, Aslanova UF, Nishino M, Farajov EI, Sugawara N, Kumagai N, Ohsaga A, Maruyama Y, Takahashi S
Clin Exp Nephrol 2006 Sep;10(3):165-74. doi: 10.1007/s10157-006-0429-4. PMID: 17009073

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