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Hyperoxemia

MedGen UID:
868512
•Concept ID:
C4022910
•
Pathologic Function
HPO: HP:0012419

Definition

An abnormally high level of blood oxygen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperoxemia

Professional guidelines

PubMed

German S3 Guideline: Oxygen Therapy in the Acute Care of Adult Patients.
Gottlieb J, Capetian P, Hamsen U, Janssens U, Karagiannidis C, Kluge S, Nothacker M, Roiter S, Volk T, Worth H, Fühner T
Respiration 2022;101(2):214-252. Epub 2021 Dec 21 doi: 10.1159/000520294. PMID: 34933311
Perceptions of Hyperoxemia and Conservative Oxygen Therapy in the Management of Acute Respiratory Failure.
Curtis BR, Rak KJ, Richardson A, Linstrum K, Kahn JM, Girard TD
Ann Am Thorac Soc 2021 Aug;18(8):1369-1379. doi: 10.1513/AnnalsATS.202007-802OC. PMID: 33332994Free PMC Article
Haemodynamic and ventilator management in patients following cardiac arrest.
Topjian AA, Berg RA, Taccone FS
Curr Opin Crit Care 2015 Jun;21(3):195-201. doi: 10.1097/MCC.0000000000000205. PMID: 25887300Free PMC Article

Recent clinical studies

Etiology

Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study.
Robba C, Battaglini D, Cinotti R, Asehnoune K, Stevens R, Taccone FS, Badenes R, Pelosi P; ENIO Collaborators
Neurocrit Care 2024 Apr;40(2):515-528. Epub 2023 Jun 15 doi: 10.1007/s12028-023-01761-x. PMID: 37322325
German S3 Guideline: Oxygen Therapy in the Acute Care of Adult Patients.
Gottlieb J, Capetian P, Hamsen U, Janssens U, Karagiannidis C, Kluge S, Nothacker M, Roiter S, Volk T, Worth H, Fühner T
Respiration 2022;101(2):214-252. Epub 2021 Dec 21 doi: 10.1159/000520294. PMID: 34933311
Benefits and risks of oxygen therapy during acute medical illness: Just a matter of dose!
Allardet-Servent J, Sicard G, Metz V, Chiche L
Rev Med Interne 2019 Oct;40(10):670-676. Epub 2019 May 1 doi: 10.1016/j.revmed.2019.04.003. PMID: 31054779
Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration.
Askie LM, Darlow BA, Finer N, Schmidt B, Stenson B, Tarnow-Mordi W, Davis PG, Carlo WA, Brocklehurst P, Davies LC, Das A, Rich W, Gantz MG, Roberts RS, Whyte RK, Costantini L, Poets C, Asztalos E, Battin M, Halliday HL, Marlow N, Tin W, King A, Juszczak E, Morley CJ, Doyle LW, Gebski V, Hunter KE, Simes RJ; Neonatal Oxygenation Prospective Meta-analysis (NeOProM) Collaboration
JAMA 2018 Jun 5;319(21):2190-2201. doi: 10.1001/jama.2018.5725. PMID: 29872859Free PMC Article
Oxygen in the critically ill: friend or foe?
Damiani E, Donati A, Girardis M
Curr Opin Anaesthesiol 2018 Apr;31(2):129-135. doi: 10.1097/ACO.0000000000000559. PMID: 29334496

Diagnosis

The Effect of Hyperoxemia on Neurological Outcomes of Adult Patients: A Systematic Review and Meta-Analysis.
Hirunpattarasilp C, Shiina H, Na-Ek N, Attwell D
Neurocrit Care 2022 Jun;36(3):1027-1043. Epub 2022 Jan 31 doi: 10.1007/s12028-021-01423-w. PMID: 35099713Free PMC Article
German S3 Guideline: Oxygen Therapy in the Acute Care of Adult Patients.
Gottlieb J, Capetian P, Hamsen U, Janssens U, Karagiannidis C, Kluge S, Nothacker M, Roiter S, Volk T, Worth H, Fühner T
Respiration 2022;101(2):214-252. Epub 2021 Dec 21 doi: 10.1159/000520294. PMID: 34933311
Hyperoxemia and Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage.
Reynolds RA, Amin SN, Jonathan SV, Tang AR, Lan M, Wang C, Bastarache JA, Ware LB, Thompson RC
Neurocrit Care 2021 Aug;35(1):30-38. Epub 2020 Nov 4 doi: 10.1007/s12028-020-01136-6. PMID: 33150573Free PMC Article
Effects of Perinatal Hyperoxia on Breathing.
Bavis RW
Compr Physiol 2020 Mar 12;10(2):597-636. doi: 10.1002/cphy.c190023. PMID: 32163205
Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration.
Askie LM, Darlow BA, Finer N, Schmidt B, Stenson B, Tarnow-Mordi W, Davis PG, Carlo WA, Brocklehurst P, Davies LC, Das A, Rich W, Gantz MG, Roberts RS, Whyte RK, Costantini L, Poets C, Asztalos E, Battin M, Halliday HL, Marlow N, Tin W, King A, Juszczak E, Morley CJ, Doyle LW, Gebski V, Hunter KE, Simes RJ; Neonatal Oxygenation Prospective Meta-analysis (NeOProM) Collaboration
JAMA 2018 Jun 5;319(21):2190-2201. doi: 10.1001/jama.2018.5725. PMID: 29872859Free PMC Article

Therapy

German S3 Guideline: Oxygen Therapy in the Acute Care of Adult Patients.
Gottlieb J, Capetian P, Hamsen U, Janssens U, Karagiannidis C, Kluge S, Nothacker M, Roiter S, Volk T, Worth H, Fühner T
Respiration 2022;101(2):214-252. Epub 2021 Dec 21 doi: 10.1159/000520294. PMID: 34933311
Perceptions of Hyperoxemia and Conservative Oxygen Therapy in the Management of Acute Respiratory Failure.
Curtis BR, Rak KJ, Richardson A, Linstrum K, Kahn JM, Girard TD
Ann Am Thorac Soc 2021 Aug;18(8):1369-1379. doi: 10.1513/AnnalsATS.202007-802OC. PMID: 33332994Free PMC Article
Benefits and risks of oxygen therapy during acute medical illness: Just a matter of dose!
Allardet-Servent J, Sicard G, Metz V, Chiche L
Rev Med Interne 2019 Oct;40(10):670-676. Epub 2019 May 1 doi: 10.1016/j.revmed.2019.04.003. PMID: 31054779
Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration.
Askie LM, Darlow BA, Finer N, Schmidt B, Stenson B, Tarnow-Mordi W, Davis PG, Carlo WA, Brocklehurst P, Davies LC, Das A, Rich W, Gantz MG, Roberts RS, Whyte RK, Costantini L, Poets C, Asztalos E, Battin M, Halliday HL, Marlow N, Tin W, King A, Juszczak E, Morley CJ, Doyle LW, Gebski V, Hunter KE, Simes RJ; Neonatal Oxygenation Prospective Meta-analysis (NeOProM) Collaboration
JAMA 2018 Jun 5;319(21):2190-2201. doi: 10.1001/jama.2018.5725. PMID: 29872859Free PMC Article
Oxygen in the critically ill: friend or foe?
Damiani E, Donati A, Girardis M
Curr Opin Anaesthesiol 2018 Apr;31(2):129-135. doi: 10.1097/ACO.0000000000000559. PMID: 29334496

Prognosis

Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study.
Robba C, Battaglini D, Cinotti R, Asehnoune K, Stevens R, Taccone FS, Badenes R, Pelosi P; ENIO Collaborators
Neurocrit Care 2024 Apr;40(2):515-528. Epub 2023 Jun 15 doi: 10.1007/s12028-023-01761-x. PMID: 37322325
Hyperoxemia and Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage.
Reynolds RA, Amin SN, Jonathan SV, Tang AR, Lan M, Wang C, Bastarache JA, Ware LB, Thompson RC
Neurocrit Care 2021 Aug;35(1):30-38. Epub 2020 Nov 4 doi: 10.1007/s12028-020-01136-6. PMID: 33150573Free PMC Article
Perioperative Lung Protection: Clinical Implications.
Hol L, Nijbroek SGLH, Schultz MJ
Anesth Analg 2020 Dec;131(6):1721-1729. doi: 10.1213/ANE.0000000000005187. PMID: 33186160
A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less?
Stolmeijer R, Bouma HR, Zijlstra JG, Drost-de Klerck AM, Ter Maaten JC, Ligtenberg JJM
Biomed Res Int 2018;2018:7841295. Epub 2018 May 14 doi: 10.1155/2018/7841295. PMID: 29888278Free PMC Article
Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration.
Askie LM, Darlow BA, Finer N, Schmidt B, Stenson B, Tarnow-Mordi W, Davis PG, Carlo WA, Brocklehurst P, Davies LC, Das A, Rich W, Gantz MG, Roberts RS, Whyte RK, Costantini L, Poets C, Asztalos E, Battin M, Halliday HL, Marlow N, Tin W, King A, Juszczak E, Morley CJ, Doyle LW, Gebski V, Hunter KE, Simes RJ; Neonatal Oxygenation Prospective Meta-analysis (NeOProM) Collaboration
JAMA 2018 Jun 5;319(21):2190-2201. doi: 10.1001/jama.2018.5725. PMID: 29872859Free PMC Article

Clinical prediction guides

Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study.
Robba C, Battaglini D, Cinotti R, Asehnoune K, Stevens R, Taccone FS, Badenes R, Pelosi P; ENIO Collaborators
Neurocrit Care 2024 Apr;40(2):515-528. Epub 2023 Jun 15 doi: 10.1007/s12028-023-01761-x. PMID: 37322325
Hyperoxia-induced lung injury in acute respiratory distress syndrome: what is its relative impact?
Lilien TA, van Meenen DMP, Schultz MJ, Bos LDJ, Bem RA
Am J Physiol Lung Cell Mol Physiol 2023 Jul 1;325(1):L9-L16. Epub 2023 May 2 doi: 10.1152/ajplung.00443.2022. PMID: 37129255
The Effect of Hyperoxemia on Neurological Outcomes of Adult Patients: A Systematic Review and Meta-Analysis.
Hirunpattarasilp C, Shiina H, Na-Ek N, Attwell D
Neurocrit Care 2022 Jun;36(3):1027-1043. Epub 2022 Jan 31 doi: 10.1007/s12028-021-01423-w. PMID: 35099713Free PMC Article
Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration.
Askie LM, Darlow BA, Finer N, Schmidt B, Stenson B, Tarnow-Mordi W, Davis PG, Carlo WA, Brocklehurst P, Davies LC, Das A, Rich W, Gantz MG, Roberts RS, Whyte RK, Costantini L, Poets C, Asztalos E, Battin M, Halliday HL, Marlow N, Tin W, King A, Juszczak E, Morley CJ, Doyle LW, Gebski V, Hunter KE, Simes RJ; Neonatal Oxygenation Prospective Meta-analysis (NeOProM) Collaboration
JAMA 2018 Jun 5;319(21):2190-2201. doi: 10.1001/jama.2018.5725. PMID: 29872859Free PMC Article
Oxygen in the critically ill: friend or foe?
Damiani E, Donati A, Girardis M
Curr Opin Anaesthesiol 2018 Apr;31(2):129-135. doi: 10.1097/ACO.0000000000000559. PMID: 29334496

Recent systematic reviews

Exposure to severe hyperoxemia worsens survival and neurological outcome in patients supported by veno-arterial extracorporeal membrane oxygenation: A meta-analysis.
Tigano S, Caruso A, Liotta C, LaVia L, Vargas M, Romagnoli S, Landoni G, Sanfilippo F
Resuscitation 2024 Jan;194:110071. Epub 2023 Dec 5 doi: 10.1016/j.resuscitation.2023.110071. PMID: 38061577
The effects of exposure to severe hyperoxemia on neurological outcome and mortality after cardiac arrest.
LA Via L, Astuto M, Bignami EG, Busalacchi D, Dezio V, Girardis M, Lanzafame B, Ristagno G, Pelosi P, Sanfilippo F
Minerva Anestesiol 2022 Oct;88(10):853-863. Epub 2022 Mar 23 doi: 10.23736/S0375-9393.22.16449-7. PMID: 35319851
Effects of hyperoxemia on aneurysmal subarachnoid hemorrhage outcomes: a systematic review and meta-analysis.
Ahn J, Mastorakos P, Sokolowski JD, Chen CJ, Kellogg R, Park MS
Neurosurg Focus 2022 Mar;52(3):E7. doi: 10.3171/2021.12.FOCUS21660. PMID: 35231897
The Effect of Hyperoxemia on Neurological Outcomes of Adult Patients: A Systematic Review and Meta-Analysis.
Hirunpattarasilp C, Shiina H, Na-Ek N, Attwell D
Neurocrit Care 2022 Jun;36(3):1027-1043. Epub 2022 Jan 31 doi: 10.1007/s12028-021-01423-w. PMID: 35099713Free PMC Article
A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less?
Stolmeijer R, Bouma HR, Zijlstra JG, Drost-de Klerck AM, Ter Maaten JC, Ligtenberg JJM
Biomed Res Int 2018;2018:7841295. Epub 2018 May 14 doi: 10.1155/2018/7841295. PMID: 29888278Free PMC Article

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