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Decreased fucosylation of O-linked protein glycosylation

MedGen UID:
868532
•Concept ID:
C4022931
•
Finding
HPO: HP:0012360

Definition

A reduction of the addition of fucose sugar units to O-linked glycans. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased fucosylation of O-linked protein glycosylation

Recent clinical studies

Etiology

Alteration of the goat milk glycoproteins N/O-glycome at different lactation stages.
Lu Y, Li C, Liu J, Huang W, Yang Y, Jia Y, Liu T, Huang L, Wang Z
Food Chem 2021 Apr 16;342:128221. Epub 2020 Oct 12 doi: 10.1016/j.foodchem.2020.128221. PMID: 33092920
MUC1 glycoforms in breast cancer--cell line T47D as a model for carcinoma-associated alterations of 0-glycosylation.
Hanisch FG, Stadie TR, Deutzmann F, Peter-Katalinic J
Eur J Biochem 1996 Feb 15;236(1):318-27. doi: 10.1111/j.1432-1033.1996.00318.x. PMID: 8617281

Diagnosis

Identification of N- and O-linked glycans recognized by AAL in saliva of patients with atrophic gastritis and gastric cancer.
Shu J, Yu H, Du H, Zhang J, Zhang K, Li X, Xie H, Li Z
Cancer Biomark 2018;22(4):669-681. doi: 10.3233/CBM-171087. PMID: 29865036
Carbohydrate and peptide structure of the alpha- and beta-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma.
Elliott MM, Kardana A, Lustbader JW, Cole LA
Endocrine 1997 Aug;7(1):15-32. doi: 10.1007/BF02778058. PMID: 9449027
Cancer-associated carbohydrates identified by monoclonal antibodies.
Sell S
Hum Pathol 1990 Oct;21(10):1003-19. doi: 10.1016/0046-8177(90)90250-9. PMID: 2210723

Therapy

Differential effect of GalNAcalpha-O-bn on intracellular trafficking in enterocytic HT-29 and Caco-2 cells: correlation with the glycosyltransferase expression pattern.
Gouyer V, Leteurtre E, Delmotte P, Steelant WF, Krzewinski-Recchi MA, Zanetta JP, Lesuffleur T, Trugnan G, Delannoy P, Huet G
J Cell Sci 2001 Apr;114(Pt 8):1455-71. doi: 10.1242/jcs.114.8.1455. PMID: 11282022

Prognosis

Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan.
Wang LW, Leonhard-Melief C, Haltiwanger RS, Apte SS
J Biol Chem 2009 Oct 30;284(44):30004-15. Epub 2009 Aug 11 doi: 10.1074/jbc.M109.038059. PMID: 19671700Free PMC Article
Cancer-associated carbohydrates identified by monoclonal antibodies.
Sell S
Hum Pathol 1990 Oct;21(10):1003-19. doi: 10.1016/0046-8177(90)90250-9. PMID: 2210723

Clinical prediction guides

Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan.
Wang LW, Leonhard-Melief C, Haltiwanger RS, Apte SS
J Biol Chem 2009 Oct 30;284(44):30004-15. Epub 2009 Aug 11 doi: 10.1074/jbc.M109.038059. PMID: 19671700Free PMC Article
Differential effect of GalNAcalpha-O-bn on intracellular trafficking in enterocytic HT-29 and Caco-2 cells: correlation with the glycosyltransferase expression pattern.
Gouyer V, Leteurtre E, Delmotte P, Steelant WF, Krzewinski-Recchi MA, Zanetta JP, Lesuffleur T, Trugnan G, Delannoy P, Huet G
J Cell Sci 2001 Apr;114(Pt 8):1455-71. doi: 10.1242/jcs.114.8.1455. PMID: 11282022

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