U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal muscle glycogen content

MedGen UID:
868581
•Concept ID:
C4022980
•
Anatomical Abnormality
HPO: HP:0012269

Definition

Any anomaly in the amount of glycogen in muscle tissue. [from HPO]

Recent clinical studies

Etiology

Low Aerobic Capacity Accelerates Lipid Accumulation and Metabolic Abnormalities Caused by High-Fat Diet-Induced Obesity in Postpartum Mice.
Lee MC, Hsu YJ, Sung HC, Wen YT, Wei L, Huang CC
Nutrients 2022 Sep 10;14(18) doi: 10.3390/nu14183746. PMID: 36145123Free PMC Article
Bisphenol AF exposure causes fasting hyperglycemia in zebrafish (Danio rerio) by interfering with glycometabolic networks.
Wei P, Jiang G, Wang H, Ru S, Zhao F
Aquat Toxicol 2021 Dec;241:106000. Epub 2021 Oct 19 doi: 10.1016/j.aquatox.2021.106000. PMID: 34715482
Impaired insulin activation and dephosphorylation of glycogen synthase in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.
Glintborg D, Højlund K, Andersen NR, Hansen BF, Beck-Nielsen H, Wojtaszewski JF
J Clin Endocrinol Metab 2008 Sep;93(9):3618-26. Epub 2008 Jun 10 doi: 10.1210/jc.2008-0760. PMID: 18544618
Impaired glycogen synthase activity and mitochondrial dysfunction in skeletal muscle: markers or mediators of insulin resistance in type 2 diabetes?
Højlund K, Beck-Nielsen H
Curr Diabetes Rev 2006 Nov;2(4):375-95. doi: 10.2174/1573399810602040375. PMID: 18220643
Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with Type II diabetes.
Levin K, Daa Schroeder H, Alford FP, Beck-Nielsen H
Diabetologia 2001 Jul;44(7):824-33. doi: 10.1007/s001250100545. PMID: 11508266

Diagnosis

Sensitive quantification of α-glucans in mouse tissues, cell cultures, and human cerebrospinal fluid.
Nitschke S, Petković S, Ahonen S, Minassian BA, Nitschke F
J Biol Chem 2020 Oct 23;295(43):14698-14709. Epub 2020 Aug 13 doi: 10.1074/jbc.RA120.015061. PMID: 32817315Free PMC Article
Cardiac manifestations of PRKAG2 mutation.
Banankhah P, Fishbein GA, Dota A, Ardehali R
BMC Med Genet 2018 Jan 3;19(1):1. doi: 10.1186/s12881-017-0512-6. PMID: 29298659Free PMC Article
Ultrastructural aspects of vacuolar degeneration of cardiomyocytes in human endomyocardial biopsies.
Takemura G, Kanamori H, Okada H, Tsujimoto A, Miyazaki N, Takada C, Hotta Y, Takatsu Y, Fujiwara T, Fujiwara H
Cardiovasc Pathol 2017 Sep-Oct;30:64-71. Epub 2017 Jul 4 doi: 10.1016/j.carpath.2017.06.012. PMID: 28779645
Diagnostic evaluation of rhabdomyolysis.
Nance JR, Mammen AL
Muscle Nerve 2015 Jun;51(6):793-810. Epub 2015 Mar 14 doi: 10.1002/mus.24606. PMID: 25678154Free PMC Article
Impaired insulin activation and dephosphorylation of glycogen synthase in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.
Glintborg D, Højlund K, Andersen NR, Hansen BF, Beck-Nielsen H, Wojtaszewski JF
J Clin Endocrinol Metab 2008 Sep;93(9):3618-26. Epub 2008 Jun 10 doi: 10.1210/jc.2008-0760. PMID: 18544618

Therapy

Skeletal Muscle Phenotype in Patients Undergoing Long-Term Hemodialysis Awaiting Kidney Transplantation.
Souweine JS, Gouzi F, Badia É, Pomies P, Garrigue V, Morena M, Hayot M, Mercier J, Ayoub B, Quintrec ML, Raynaud F, Cristol JP
Clin J Am Soc Nephrol 2021 Nov;16(11):1676-1685. doi: 10.2215/CJN.02390221. PMID: 34750160Free PMC Article
GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance.
Biensø RS, Ringholm S, Kiilerich K, Aachmann-Andersen NJ, Krogh-Madsen R, Guerra B, Plomgaard P, van Hall G, Treebak JT, Saltin B, Lundby C, Calbet JA, Pilegaard H, Wojtaszewski JF
Diabetes 2012 May;61(5):1090-9. Epub 2012 Mar 8 doi: 10.2337/db11-0884. PMID: 22403297Free PMC Article
Impaired insulin activation and dephosphorylation of glycogen synthase in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.
Glintborg D, Højlund K, Andersen NR, Hansen BF, Beck-Nielsen H, Wojtaszewski JF
J Clin Endocrinol Metab 2008 Sep;93(9):3618-26. Epub 2008 Jun 10 doi: 10.1210/jc.2008-0760. PMID: 18544618
Slowed glycogen utilization enhances exercise endurance in patients with heart failure.
Mancini D, Benaminovitz A, Cordisco ME, Karmally W, Weinberg A
J Am Coll Cardiol 1999 Nov 15;34(6):1807-12. doi: 10.1016/s0735-1097(99)00413-1. PMID: 10577574
The effect of treatment with recombinant human erythropoietin on the histological appearance and glycogen content of skeletal muscle in patients with chronic renal failure treated by regular hospital haemodialysis.
Davenport A, King RF, Ironside JW, Will EJ, Davison AM
Nephron 1993;64(1):89-94. doi: 10.1159/000187284. PMID: 8502342

Prognosis

Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease.
Koeberl DD, Case LE, Smith EC, Walters C, Han SO, Li Y, Chen W, Hornik CP, Huffman KM, Kraus WE, Thurberg BL, Corcoran DL, Bali D, Bursac N, Kishnani PS
Mol Ther 2018 Sep 5;26(9):2304-2314. Epub 2018 Jul 5 doi: 10.1016/j.ymthe.2018.06.023. PMID: 30025991Free PMC Article
Reversible infantile respiratory chain deficiency is a unique, genetically heterogenous mitochondrial disease.
Uusimaa J, Jungbluth H, Fratter C, Crisponi G, Feng L, Zeviani M, Hughes I, Treacy EP, Birks J, Brown GK, Sewry CA, McDermott M, Muntoni F, Poulton J
J Med Genet 2011 Oct;48(10):660-668. doi: 10.1136/jmg.2011.089995. PMID: 21931168Free PMC Article
Nosology of lysosomal glycogen storage diseases without in vitro acid maltase deficiency. Delineation of a neonatal form.
Verloes A, Massin M, Lombet J, Grattagliano B, Soyeur D, Rigo J, Koulischer L, Van Hoof F
Am J Med Genet 1997 Oct 17;72(2):135-42. PMID: 9382133
Histological alterations in chronically hypoperfused myocardium. Correlation with PET findings.
Maes A, Flameng W, Nuyts J, Borgers M, Shivalkar B, Ausma J, Bormans G, Schiepers C, De Roo M, Mortelmans L
Circulation 1994 Aug;90(2):735-45. doi: 10.1161/01.cir.90.2.735. PMID: 8044942
Morphologic findings in biopsied skeletal muscle and cultured fibroblasts from a female patient with Danon's disease (lysosomal glycogen storage disease without acid maltase deficiency).
Usuki F, Takenaga S, Higuchi I, Kashio N, Nakagawa M, Osame M
J Neurol Sci 1994 Dec 1;127(1):54-60. doi: 10.1016/0022-510x(94)90135-x. PMID: 7699392

Clinical prediction guides

Low Aerobic Capacity Accelerates Lipid Accumulation and Metabolic Abnormalities Caused by High-Fat Diet-Induced Obesity in Postpartum Mice.
Lee MC, Hsu YJ, Sung HC, Wen YT, Wei L, Huang CC
Nutrients 2022 Sep 10;14(18) doi: 10.3390/nu14183746. PMID: 36145123Free PMC Article
Skeletal Muscle Phenotype in Patients Undergoing Long-Term Hemodialysis Awaiting Kidney Transplantation.
Souweine JS, Gouzi F, Badia É, Pomies P, Garrigue V, Morena M, Hayot M, Mercier J, Ayoub B, Quintrec ML, Raynaud F, Cristol JP
Clin J Am Soc Nephrol 2021 Nov;16(11):1676-1685. doi: 10.2215/CJN.02390221. PMID: 34750160Free PMC Article
Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease.
Koeberl DD, Case LE, Smith EC, Walters C, Han SO, Li Y, Chen W, Hornik CP, Huffman KM, Kraus WE, Thurberg BL, Corcoran DL, Bali D, Bursac N, Kishnani PS
Mol Ther 2018 Sep 5;26(9):2304-2314. Epub 2018 Jul 5 doi: 10.1016/j.ymthe.2018.06.023. PMID: 30025991Free PMC Article
The Angiotensin Converting Enzyme Insertion/Deletion Polymorphism Modifies Exercise-Induced Muscle Metabolism.
Vaughan D, Brogioli M, Maier T, White A, Waldron S, Rittweger J, Toigo M, Wettstein J, Laczko E, Flück M
PLoS One 2016;11(3):e0149046. Epub 2016 Mar 16 doi: 10.1371/journal.pone.0149046. PMID: 26982073Free PMC Article
Overexpression of the orphan receptor Nur77 alters glucose metabolism in rat muscle cells and rat muscle in vivo.
Kanzleiter T, Preston E, Wilks D, Ho B, Benrick A, Reznick J, Heilbronn LK, Turner N, Cooney GJ
Diabetologia 2010 Jun;53(6):1174-83. Epub 2010 Mar 9 doi: 10.1007/s00125-010-1703-2. PMID: 20217038

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...