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Reduced number of corneal endothelial cells

MedGen UID:
868918
•Concept ID:
C4023329
•
Finding
HPO: HP:0011491

Definition

A reduction in the number of corneal endothelial cells. [from HPO]

Professional guidelines

PubMed

Photorefractive intrastromal corneal crosslinking for the treatment of myopic refractive errors: Six-month interim findings.
Elling M, Kersten-Gomez I, Dick HB
J Cataract Refract Surg 2017 Jun;43(6):789-795. doi: 10.1016/j.jcrs.2017.03.036. PMID: 28732613
Novel mucoadhesive polysaccharide isolated from Bletilla striata improves the intraocular penetration and efficacy of levofloxacin in the topical treatment of experimental bacterial keratitis.
Wu XG, Xin M, Chen H, Yang LN, Jiang HR
J Pharm Pharmacol 2010 Sep;62(9):1152-7. doi: 10.1111/j.2042-7158.2010.01137.x. PMID: 20796194
Synthesis, characterization, and preliminary assessment of anti-Flt1 peptide-hyaluronate conjugate for the treatment of corneal neovascularization.
Oh EJ, Park K, Choi JS, Joo CK, Hahn SK
Biomaterials 2009 Oct;30(30):6026-34. Epub 2009 Jul 31 doi: 10.1016/j.biomaterials.2009.07.024. PMID: 19647313

Recent clinical studies

Etiology

Optimization of polycaprolactone - based nanofiber matrices for the cultivation of corneal endothelial cells.
Himmler M, Garreis F, Paulsen F, Schubert DW, Fuchsluger TA
Sci Rep 2021 Sep 22;11(1):18858. doi: 10.1038/s41598-021-98426-6. PMID: 34552187Free PMC Article
Corneal endothelial status in different grades of late spontaneous in-the-bag IOL dislocation.
Vaiciuliene R, Jasinskas V
Int Ophthalmol 2021 May;41(5):1625-1634. Epub 2021 Feb 19 doi: 10.1007/s10792-021-01702-7. PMID: 33606154
The Effect of Tube Location on Corneal Endothelial Cells in Patients with Ahmed Glaucoma Valve.
Zhang Q, Liu Y, Thanapaisal S, Oatts J, Luo Y, Ying GS, Wang J, McLeod SD, Gedde SJ, Han Y
Ophthalmology 2021 Feb;128(2):218-226. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.050. PMID: 32603727Free PMC Article
EK (DLEK, DSEK, DMEK): New Frontier in Cornea Surgery.
Price MO, Gupta P, Lass J, Price FW Jr
Annu Rev Vis Sci 2017 Sep 15;3:69-90. Epub 2017 Jul 11 doi: 10.1146/annurev-vision-102016-061400. PMID: 28697678
Ipsilateral rotational autokeratoplasty: a review.
Arnalich-Montiel F, Dart JK
Eye (Lond) 2009 Oct;23(10):1931-8. Epub 2009 Jan 9 doi: 10.1038/eye.2008.386. PMID: 19136924

Diagnosis

Corneal endothelial status in different grades of late spontaneous in-the-bag IOL dislocation.
Vaiciuliene R, Jasinskas V
Int Ophthalmol 2021 May;41(5):1625-1634. Epub 2021 Feb 19 doi: 10.1007/s10792-021-01702-7. PMID: 33606154
The Effect of Tube Location on Corneal Endothelial Cells in Patients with Ahmed Glaucoma Valve.
Zhang Q, Liu Y, Thanapaisal S, Oatts J, Luo Y, Ying GS, Wang J, McLeod SD, Gedde SJ, Han Y
Ophthalmology 2021 Feb;128(2):218-226. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.050. PMID: 32603727Free PMC Article
Corneal endothelial cell abnormalities in X-linked Alport syndrome.
Nicklason E, Mack H, Beltz J, Jacob J, Farahani M, Colville D, Savige J
Ophthalmic Genet 2020 Feb;41(1):13-19. Epub 2020 Mar 11 doi: 10.1080/13816810.2019.1709126. PMID: 32159412
Further Analysis of the Predictability of Corneal Endothelial Cell Density Estimates When Polymegethism Is Present.
Doughty MJ
Cornea 2017 Aug;36(8):973-979. doi: 10.1097/ICO.0000000000001218. PMID: 28614153
Ipsilateral rotational autokeratoplasty: a review.
Arnalich-Montiel F, Dart JK
Eye (Lond) 2009 Oct;23(10):1931-8. Epub 2009 Jan 9 doi: 10.1038/eye.2008.386. PMID: 19136924

Therapy

The Effect of Tube Location on Corneal Endothelial Cells in Patients with Ahmed Glaucoma Valve.
Zhang Q, Liu Y, Thanapaisal S, Oatts J, Luo Y, Ying GS, Wang J, McLeod SD, Gedde SJ, Han Y
Ophthalmology 2021 Feb;128(2):218-226. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.050. PMID: 32603727Free PMC Article
Could adverse effects and complications of selective laser trabeculoplasty be decreased by low-power laser therapy?
Paiva ACM, da Fonseca AS
Int Ophthalmol 2019 Jan;39(1):243-257. Epub 2017 Nov 30 doi: 10.1007/s10792-017-0775-0. PMID: 29189945
Role of Dendritic Cells and Inflammatory Cells in Herpetic Endotheliitis: Analysis Using In Vivo Confocal Microscopy.
Wang T, Dong M, Jiang Y, Wang S, Shi W
Cornea 2018 Jun;37(6):748-754. doi: 10.1097/ICO.0000000000001571. PMID: 29543663
EK (DLEK, DSEK, DMEK): New Frontier in Cornea Surgery.
Price MO, Gupta P, Lass J, Price FW Jr
Annu Rev Vis Sci 2017 Sep 15;3:69-90. Epub 2017 Jul 11 doi: 10.1146/annurev-vision-102016-061400. PMID: 28697678
Comparison of corneal keratocytes before and after corneal collagen cross-linking in keratoconus patients.
Aminifard MN, Khallaghi H, Mohammadi M, Jafarzadeh R
Int Ophthalmol 2015 Dec;35(6):785-92. Epub 2015 Feb 4 doi: 10.1007/s10792-015-0041-2. PMID: 25649258

Prognosis

The Effect of Tube Location on Corneal Endothelial Cells in Patients with Ahmed Glaucoma Valve.
Zhang Q, Liu Y, Thanapaisal S, Oatts J, Luo Y, Ying GS, Wang J, McLeod SD, Gedde SJ, Han Y
Ophthalmology 2021 Feb;128(2):218-226. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.050. PMID: 32603727Free PMC Article
Corneal endothelial cell abnormalities in X-linked Alport syndrome.
Nicklason E, Mack H, Beltz J, Jacob J, Farahani M, Colville D, Savige J
Ophthalmic Genet 2020 Feb;41(1):13-19. Epub 2020 Mar 11 doi: 10.1080/13816810.2019.1709126. PMID: 32159412
A physical biomarker of the quality of cultured corneal endothelial cells and of the long-term prognosis of corneal restoration in patients.
Yamamoto A, Tanaka H, Toda M, Sotozono C, Hamuro J, Kinoshita S, Ueno M, Tanaka M
Nat Biomed Eng 2019 Dec;3(12):953-960. Epub 2019 Jul 22 doi: 10.1038/s41551-019-0429-9. PMID: 31332343
Further Analysis of the Predictability of Corneal Endothelial Cell Density Estimates When Polymegethism Is Present.
Doughty MJ
Cornea 2017 Aug;36(8):973-979. doi: 10.1097/ICO.0000000000001218. PMID: 28614153
Functional measurements on the enlarged endothelial cells of corneal transplants.
Bourne WM
Trans Am Ophthalmol Soc 1995;93:65-79; discussion 79-82. PMID: 8719671Free PMC Article

Clinical prediction guides

Optimization of polycaprolactone - based nanofiber matrices for the cultivation of corneal endothelial cells.
Himmler M, Garreis F, Paulsen F, Schubert DW, Fuchsluger TA
Sci Rep 2021 Sep 22;11(1):18858. doi: 10.1038/s41598-021-98426-6. PMID: 34552187Free PMC Article
Corneal endothelial status in different grades of late spontaneous in-the-bag IOL dislocation.
Vaiciuliene R, Jasinskas V
Int Ophthalmol 2021 May;41(5):1625-1634. Epub 2021 Feb 19 doi: 10.1007/s10792-021-01702-7. PMID: 33606154
Role of Dendritic Cells and Inflammatory Cells in Herpetic Endotheliitis: Analysis Using In Vivo Confocal Microscopy.
Wang T, Dong M, Jiang Y, Wang S, Shi W
Cornea 2018 Jun;37(6):748-754. doi: 10.1097/ICO.0000000000001571. PMID: 29543663
Further Analysis of the Predictability of Corneal Endothelial Cell Density Estimates When Polymegethism Is Present.
Doughty MJ
Cornea 2017 Aug;36(8):973-979. doi: 10.1097/ICO.0000000000001218. PMID: 28614153
Comparison of corneal keratocytes before and after corneal collagen cross-linking in keratoconus patients.
Aminifard MN, Khallaghi H, Mohammadi M, Jafarzadeh R
Int Ophthalmol 2015 Dec;35(6):785-92. Epub 2015 Feb 4 doi: 10.1007/s10792-015-0041-2. PMID: 25649258

Recent systematic reviews

Endothelial keratoplasty versus penetrating keratoplasty for Fuchs endothelial dystrophy.
Nanavaty MA, Wang X, Shortt AJ
Cochrane Database Syst Rev 2014 Feb 14;2014(2):CD008420. doi: 10.1002/14651858.CD008420.pub3. PMID: 24526345Free PMC Article
Endothelial keratoplasty versus penetrating keratoplasty for Fuchs endothelial dystrophy.
Nanavaty MA, Shortt AJ
Cochrane Database Syst Rev 2011 Jul 6;(7):CD008420. doi: 10.1002/14651858.CD008420.pub2. PMID: 21735430

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