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Abnormal small intestinal villus morphology

MedGen UID:
868929
•Concept ID:
C4023341
•
Anatomical Abnormality
Synonyms: Abnormal shape of small intestinal villus; Abnormality of small intestinal villus morphology
 
HPO: HP:0011472

Professional guidelines

PubMed

Small bowel enterocyte abnormalities caused by methotrexate treatment in acute lymphoblastic leukaemia of childhood.
Gwavava NJ, Pinkerton CR, Glasgow JF, Sloan JM, Bridges JM
J Clin Pathol 1981 Jul;34(7):790-5. doi: 10.1136/jcp.34.7.790. PMID: 6943149Free PMC Article
Radiation enteritis in children. A retrospective review, clinicopathologic correlation, and dietary management.
Donaldson SS, Jundt S, Ricour C, Sarrazin D, Lemerle J, Schweisguth O
Cancer 1975 Apr;35(4):1167-78. doi: 10.1002/1097-0142(197504)35:4<1167::aid-cncr2820350423>3.0.co;2-y. PMID: 163677

Recent clinical studies

Etiology

Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.
Israelyan N, Del Colle A, Li Z, Park Y, Xing A, Jacobsen JPR, Luna RA, Jensen DD, Madra M, Saurman V, Rahim R, Latorre R, Law K, Carson W, Bunnett NW, Caron MG, Margolis KG
Gastroenterology 2019 Aug;157(2):507-521.e4. Epub 2019 May 7 doi: 10.1053/j.gastro.2019.04.022. PMID: 31071306Free PMC Article
Short bowel mucosal morphology, proliferation and inflammation at first and repeat STEP procedures.
Mutanen A, Barrett M, Feng Y, Lohi J, Rabah R, Teitelbaum DH, Pakarinen MP
J Pediatr Surg 2019 Mar;54(3):511-516. Epub 2018 Apr 17 doi: 10.1016/j.jpedsurg.2018.04.016. PMID: 29753524
Histological abnormalities of the small bowel mucosa in cirrhosis and portal hypertension.
Wakim-Fleming J, Zein NN, Bennett A, Lopez R, Santisi J, Carey WD
World J Gastroenterol 2008 Nov 7;14(41):6370-5. doi: 10.3748/wjg.14.6370. PMID: 19009654Free PMC Article
Pediatric duodenal biopsies: mucosal morphology and glycohydrolase expression do not change along the duodenum.
Van Beers EH, Einerhand AW, Taminiau JA, Heymans HS, Dekker J, Büller HA
J Pediatr Gastroenterol Nutr 1998 Feb;26(2):186-93. doi: 10.1097/00005176-199802000-00013. PMID: 9481636
Intestinal immune cells in Strongyloides stercoralis infection.
Trajman A, MacDonald TT, Elia CC
J Clin Pathol 1997 Dec;50(12):991-5. doi: 10.1136/jcp.50.12.991. PMID: 9516879Free PMC Article

Diagnosis

Measuring Change In Small Intestinal Histology In Patients With Celiac Disease.
Adelman DC, Murray J, Wu TT, Mäki M, Green PH, Kelly CP
Am J Gastroenterol 2018 Mar;113(3):339-347. Epub 2018 Feb 20 doi: 10.1038/ajg.2017.480. PMID: 29460921
Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis.
Lee SJ, Lee J, Li KK, Holland D, Maughan H, Guttman DS, Yusta B, Drucker DJ
Endocrinology 2012 Mar;153(3):1141-51. Epub 2012 Jan 17 doi: 10.1210/en.2011-1954. PMID: 22253424Free PMC Article
Histological abnormalities of the small bowel mucosa in cirrhosis and portal hypertension.
Wakim-Fleming J, Zein NN, Bennett A, Lopez R, Santisi J, Carey WD
World J Gastroenterol 2008 Nov 7;14(41):6370-5. doi: 10.3748/wjg.14.6370. PMID: 19009654Free PMC Article
Food-induced malabsorption syndromes.
Savilahti E
J Pediatr Gastroenterol Nutr 2000;30 Suppl:S61-6. doi: 10.1097/00005176-200001001-00010. PMID: 10634301
Pediatric duodenal biopsies: mucosal morphology and glycohydrolase expression do not change along the duodenum.
Van Beers EH, Einerhand AW, Taminiau JA, Heymans HS, Dekker J, Büller HA
J Pediatr Gastroenterol Nutr 1998 Feb;26(2):186-93. doi: 10.1097/00005176-199802000-00013. PMID: 9481636

Therapy

Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.
Israelyan N, Del Colle A, Li Z, Park Y, Xing A, Jacobsen JPR, Luna RA, Jensen DD, Madra M, Saurman V, Rahim R, Latorre R, Law K, Carson W, Bunnett NW, Caron MG, Margolis KG
Gastroenterology 2019 Aug;157(2):507-521.e4. Epub 2019 May 7 doi: 10.1053/j.gastro.2019.04.022. PMID: 31071306Free PMC Article
Short bowel mucosal morphology, proliferation and inflammation at first and repeat STEP procedures.
Mutanen A, Barrett M, Feng Y, Lohi J, Rabah R, Teitelbaum DH, Pakarinen MP
J Pediatr Surg 2019 Mar;54(3):511-516. Epub 2018 Apr 17 doi: 10.1016/j.jpedsurg.2018.04.016. PMID: 29753524
Transglutaminase 2-specific coeliac disease autoantibodies induce morphological changes and signs of inflammation in the small-bowel mucosa of mice.
Kalliokoski S, Piqueras VO, Frías R, Sulic AM, Määttä JA, Kähkönen N, Viiri K, Huhtala H, Pasternack A, Laurila K, Sblattero D, Korponay-Szabó IR, Mäki M, Caja S, Kaukinen K, Lindfors K
Amino Acids 2017 Mar;49(3):529-540. Epub 2016 Aug 9 doi: 10.1007/s00726-016-2306-0. PMID: 27503559
Glutamine: commercially essential or conditionally essential? A critical appraisal of the human data.
Buchman AL
Am J Clin Nutr 2001 Jul;74(1):25-32. doi: 10.1093/ajcn/74.1.25. PMID: 11451714
A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS.
Noyer CM, Simon D, Borczuk A, Brandt LJ, Lee MJ, Nehra V
Am J Gastroenterol 1998 Jun;93(6):972-5. doi: 10.1111/j.1572-0241.1998.00290.x. PMID: 9647031

Prognosis

Measuring Change In Small Intestinal Histology In Patients With Celiac Disease.
Adelman DC, Murray J, Wu TT, Mäki M, Green PH, Kelly CP
Am J Gastroenterol 2018 Mar;113(3):339-347. Epub 2018 Feb 20 doi: 10.1038/ajg.2017.480. PMID: 29460921
Application of novel magnified single balloon enteroscopy for a patient with Cronkhite-Canada syndrome.
Murata M, Bamba S, Takahashi K, Imaeda H, Nishida A, Inatomi O, Tsujikawa T, Kushima R, Sugimoto M, Andoh A
World J Gastroenterol 2017 Jun 14;23(22):4121-4126. doi: 10.3748/wjg.v23.i22.4121. PMID: 28652665Free PMC Article
Histological abnormalities of the small bowel mucosa in cirrhosis and portal hypertension.
Wakim-Fleming J, Zein NN, Bennett A, Lopez R, Santisi J, Carey WD
World J Gastroenterol 2008 Nov 7;14(41):6370-5. doi: 10.3748/wjg.14.6370. PMID: 19009654Free PMC Article
Disaccharidase activities in children: normal values and comparison based on symptoms and histologic changes.
Gupta SK, Chong SK, Fitzgerald JF
J Pediatr Gastroenterol Nutr 1999 Mar;28(3):246-51. doi: 10.1097/00005176-199903000-00007. PMID: 10067723
Duodenal histology, ulceration, and Helicobacter pylori in the presence or absence of non-steroidal anti-inflammatory drugs.
Taha AS, Dahill S, Nakshabendi I, Lee FD, Sturrock RD, Russell RI
Gut 1993 Sep;34(9):1162-6. doi: 10.1136/gut.34.9.1162. PMID: 8406146Free PMC Article

Clinical prediction guides

Short bowel mucosal morphology, proliferation and inflammation at first and repeat STEP procedures.
Mutanen A, Barrett M, Feng Y, Lohi J, Rabah R, Teitelbaum DH, Pakarinen MP
J Pediatr Surg 2019 Mar;54(3):511-516. Epub 2018 Apr 17 doi: 10.1016/j.jpedsurg.2018.04.016. PMID: 29753524
Measuring Change In Small Intestinal Histology In Patients With Celiac Disease.
Adelman DC, Murray J, Wu TT, Mäki M, Green PH, Kelly CP
Am J Gastroenterol 2018 Mar;113(3):339-347. Epub 2018 Feb 20 doi: 10.1038/ajg.2017.480. PMID: 29460921
Histological abnormalities of the small bowel mucosa in cirrhosis and portal hypertension.
Wakim-Fleming J, Zein NN, Bennett A, Lopez R, Santisi J, Carey WD
World J Gastroenterol 2008 Nov 7;14(41):6370-5. doi: 10.3748/wjg.14.6370. PMID: 19009654Free PMC Article
Uncertain clinical significance of duodenal mucosal abnormalities in HIV-infected individuals. Results of a case-control study.
Rabeneck L, Genta RM, Risser JM, Bailey ME, Clarridge JE, Gyorkey F
J Clin Gastroenterol 1996 Jul;23(1):11-4. doi: 10.1097/00004836-199607000-00004. PMID: 8835891
Ultrastructural changes in the upper small intestinal mucosa in patients with cholera.
Mathan MM, Chandy G, Mathan VI
Gastroenterology 1995 Aug;109(2):422-30. doi: 10.1016/0016-5085(95)90329-1. PMID: 7615191

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