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Abnormal corpus striatum morphology

MedGen UID:
869185
•Concept ID:
C4023607
•
Anatomical Abnormality
Synonym: Abnormality of the striatum
 
HPO: HP:0010994

Definition

Abnormality of the striatum, which is the largest nucleus of the basal ganglia, comprising the caudate, putamen and ventral striatum, including the nucleus accumbens. [from HPO]

Conditions with this feature

Striatal degeneration, autosomal dominant 2
MedGen UID:
934758
•Concept ID:
C4310791
•
Disease or Syndrome
Autosomal dominant striatal degeneration-2 is a neurologic disorder characterized by hyperkinetic movements, mainly chorea, resulting from dysfunction of the basal ganglia. Although symptoms appear in the first decade, the disorder is not progressive (summary by Mencacci et al., 2016). For a discussion of genetic heterogeneity of ADSD, see ADSD1 (609161).
See: Condition Record
Striatal degeneration, autosomal dominant 2

Professional guidelines

PubMed

Lithium treatment impacts nucleus accumbens shape in bipolar disorder.
Vecchio D, Piras F, Piras F, Banaj N, Janiri D, Simonetti A, Sani G, Spalletta G
Neuroimage Clin 2020;25:102167. Epub 2020 Jan 10 doi: 10.1016/j.nicl.2020.102167. PMID: 31972398Free PMC Article
Levodopa treatment and dendritic spine pathology.
Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414Free PMC Article
Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment.
Laruelle M, Kegeles LS, Abi-Dargham A
Ann N Y Acad Sci 2003 Nov;1003:138-58. doi: 10.1196/annals.1300.063. PMID: 14684442

Recent clinical studies

Etiology

Task-induced subjective fatigue and resting-state striatal connectivity following traumatic brain injury.
Bruijel J, Quaedflieg CWEM, Otto T, van de Ven V, Stapert SZ, van Heugten C, Vermeeren A
Neuroimage Clin 2022;33:102936. Epub 2022 Jan 4 doi: 10.1016/j.nicl.2022.102936. PMID: 35007852Free PMC Article
Neuro-Immune Cross-Talk in the Striatum: From Basal Ganglia Physiology to Circuit Dysfunction.
Mancini A, Ghiglieri V, Parnetti L, Calabresi P, Di Filippo M
Front Immunol 2021;12:644294. Epub 2021 Apr 19 doi: 10.3389/fimmu.2021.644294. PMID: 33953715Free PMC Article
Basal ganglia and thalamic morphology in schizophrenia and bipolar disorder.
Womer FY, Wang L, Alpert KI, Smith MJ, Csernansky JG, Barch DM, Mamah D
Psychiatry Res 2014 Aug 30;223(2):75-83. Epub 2014 Jun 6 doi: 10.1016/j.pscychresns.2014.05.017. PMID: 24957866Free PMC Article
The dopamine hypothesis of schizophrenia: version III--the final common pathway.
Howes OD, Kapur S
Schizophr Bull 2009 May;35(3):549-62. Epub 2009 Mar 26 doi: 10.1093/schbul/sbp006. PMID: 19325164Free PMC Article
Caudate infarcts.
Caplan LR, Schmahmann JD, Kase CS, Feldmann E, Baquis G, Greenberg JP, Gorelick PB, Helgason C, Hier DB
Arch Neurol 1990 Feb;47(2):133-43. doi: 10.1001/archneur.1990.00530020029011. PMID: 2405818

Diagnosis

An Autopsy Series of Seven Cases of VPS13A Disease (Chorea-Acanthocytosis).
Ditzel RM Jr, Walker RH, Nirenberg MJ, Tetlow AM, Farrell K, Lind-Watson KJ, Thorn EL, Dangoor DK, Gordon R, De Sanctis C, Barton B, Karp BI, Kirby A, Lett DJ, Mente K, Simon DK, Velayos-Baeza A, Miltenberger-Miltenyi G, Humphrey J, Crary JF
Mov Disord 2023 Dec;38(12):2163-2172. Epub 2023 Sep 5 doi: 10.1002/mds.29589. PMID: 37670483Free PMC Article
"Diabetic striatopathy": clinical presentations, controversy, pathogenesis, treatments, and outcomes.
Chua CB, Sun CK, Hsu CW, Tai YC, Liang CY, Tsai IT
Sci Rep 2020 Jan 31;10(1):1594. doi: 10.1038/s41598-020-58555-w. PMID: 32005905Free PMC Article
Postural & striatal deformities in Parkinson`s disease: Are these rare?
Pandey S, Garg H
Indian J Med Res 2016 Jan;143(1):11-7. doi: 10.4103/0971-5916.178577. PMID: 26997007Free PMC Article
Parkinson's disease: diagnosis.
Brooks DJ
Parkinsonism Relat Disord 2012 Jan;18 Suppl 1:S31-3. doi: 10.1016/S1353-8020(11)70012-8. PMID: 22166447
The dopamine hypothesis of schizophrenia: version III--the final common pathway.
Howes OD, Kapur S
Schizophr Bull 2009 May;35(3):549-62. Epub 2009 Mar 26 doi: 10.1093/schbul/sbp006. PMID: 19325164Free PMC Article

Therapy

Potential mechanisms for phencyclidine/ketamine-induced brain structural alterations and behavioral consequences.
Wang C, Inselman A, Liu S, Liu F
Neurotoxicology 2020 Jan;76:213-219. Epub 2019 Dec 5 doi: 10.1016/j.neuro.2019.12.005. PMID: 31812709
Motor complications in Parkinson's disease: Striatal molecular and electrophysiological mechanisms of dyskinesias.
Picconi B, Hernández LF, Obeso JA, Calabresi P
Mov Disord 2018 Jul;33(6):867-876. Epub 2017 Dec 8 doi: 10.1002/mds.27261. PMID: 29219207
Levodopa treatment and dendritic spine pathology.
Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414Free PMC Article
Exercise effects on depression: Possible neural mechanisms.
Gujral S, Aizenstein H, Reynolds CF 3rd, Butters MA, Erickson KI
Gen Hosp Psychiatry 2017 Nov;49:2-10. doi: 10.1016/j.genhosppsych.2017.04.012. PMID: 29122145Free PMC Article
Functional organization of the basal ganglia: therapeutic implications for Parkinson's disease.
Obeso JA, Rodríguez-Oroz MC, Benitez-Temino B, Blesa FJ, Guridi J, Marin C, Rodriguez M
Mov Disord 2008;23 Suppl 3:S548-59. doi: 10.1002/mds.22062. PMID: 18781672

Prognosis

Network diffusion modeling predicts neurodegeneration in traumatic brain injury.
Poudel GR, Dominguez D JF, Verhelst H, Vander Linden C, Deblaere K, Jones DK, Cerin E, Vingerhoets G, Caeyenberghs K
Ann Clin Transl Neurol 2020 Mar;7(3):270-279. Epub 2020 Feb 27 doi: 10.1002/acn3.50984. PMID: 32105414Free PMC Article
Apathy Is Related to Cognitive Control and Striatum Volumes in Prodromal Huntington's Disease.
Misiura MB, Ciarochi J, Vaidya J, Bockholt J, Johnson HJ, Calhoun VD, Paulsen JS, Turner JA; PREDICT-HD Investigators & Working Group
J Int Neuropsychol Soc 2019 May;25(5):462-469. Epub 2019 Feb 26 doi: 10.1017/S1355617719000067. PMID: 30806337Free PMC Article
Regional subcortical shape analysis in premanifest Huntington's disease.
Tang X, Ross CA, Johnson H, Paulsen JS, Younes L, Albin RL, Ratnanather JT, Miller MI
Hum Brain Mapp 2019 Apr 1;40(5):1419-1433. Epub 2018 Oct 30 doi: 10.1002/hbm.24456. PMID: 30376191Free PMC Article
Pallidal stimulation for dystonia.
Lozano AM, Abosch A
Adv Neurol 2004;94:301-8. PMID: 14509687
Glycogenosis type VIII.
Kornfeld M, LeBaron M
J Neuropathol Exp Neurol 1984 Nov;43(6):568-79. doi: 10.1097/00005072-198411000-00002. PMID: 6594438

Clinical prediction guides

Functional and Structural Connectivity of the Cerebellar Nuclei With the Striatum and Cerebral Cortex in First-Episode Psychosis.
Lee KH, Oh H, Suh JS, Cho KIK, Yoon YB, Shin WG, Lee TY, Kwon JS
J Neuropsychiatry Clin Neurosci 2019 Spring;31(2):143-151. Epub 2018 Dec 18 doi: 10.1176/appi.neuropsych.17110276. PMID: 30561280
Exercise effects on depression: Possible neural mechanisms.
Gujral S, Aizenstein H, Reynolds CF 3rd, Butters MA, Erickson KI
Gen Hosp Psychiatry 2017 Nov;49:2-10. doi: 10.1016/j.genhosppsych.2017.04.012. PMID: 29122145Free PMC Article
Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia.
Eskow Jaunarajs KL, Bonsi P, Chesselet MF, Standaert DG, Pisani A
Prog Neurobiol 2015 Apr;127-128:91-107. Epub 2015 Feb 17 doi: 10.1016/j.pneurobio.2015.02.002. PMID: 25697043Free PMC Article
The impairment of cholesterol metabolism in Huntington disease.
Leoni V, Caccia C
Biochim Biophys Acta 2015 Aug;1851(8):1095-105. Epub 2015 Jan 14 doi: 10.1016/j.bbalip.2014.12.018. PMID: 25596342
Basal ganglia and thalamic morphology in schizophrenia and bipolar disorder.
Womer FY, Wang L, Alpert KI, Smith MJ, Csernansky JG, Barch DM, Mamah D
Psychiatry Res 2014 Aug 30;223(2):75-83. Epub 2014 Jun 6 doi: 10.1016/j.pscychresns.2014.05.017. PMID: 24957866Free PMC Article

Recent systematic reviews

Resting-state fMRI in depressive and (hypo)manic mood states in bipolar disorders: A systematic review.
Claeys EHI, Mantingh T, Morrens M, Yalin N, Stokes PRA
Prog Neuropsychopharmacol Biol Psychiatry 2022 Mar 8;113:110465. Epub 2021 Nov 2 doi: 10.1016/j.pnpbp.2021.110465. PMID: 34736998
Advanced techniques in magnetic resonance imaging of the brain in children with ADHD.
Pastura G, Mattos P, Gasparetto EL, Araújo AP
Arq Neuropsiquiatr 2011 Apr;69(2A):242-52. doi: 10.1590/s0004-282x2011000200020. PMID: 21537569
Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis.
Arnone D, Cavanagh J, Gerber D, Lawrie SM, Ebmeier KP, McIntosh AM
Br J Psychiatry 2009 Sep;195(3):194-201. doi: 10.1192/bjp.bp.108.059717. PMID: 19721106
Towards a neuroanatomy of autism: a systematic review and meta-analysis of structural magnetic resonance imaging studies.
Stanfield AC, McIntosh AM, Spencer MD, Philip R, Gaur S, Lawrie SM
Eur Psychiatry 2008 Jun;23(4):289-99. Epub 2007 Aug 31 doi: 10.1016/j.eurpsy.2007.05.006. PMID: 17765485

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