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Abnormal circulating methionine concentration

MedGen UID:
869242
•Concept ID:
C4023665
•
Finding
Synonym: Abnormality of methionine metabolism
 
HPO: HP:0010901

Definition

Any deviation from the normal concentration of methionine in the blood circulation. [from HPO]

Recent clinical studies

Etiology

Targeted metabolomic analysis of serum amino acids in the adult Fontan patient with a dominant left ventricle.
Michel M, Dubowy KO, Entenmann A, Karall D, Adam MG, Zlamy M, Odri Komazec I, Geiger R, Niederwanger C, Salvador C, Müller U, Laser KT, Scholl-Bürgi S
Sci Rep 2020 Jun 2;10(1):8930. doi: 10.1038/s41598-020-65852-x. PMID: 32488174Free PMC Article
Abnormal liver phosphatidylcholine synthesis revealed in patients with acute respiratory distress syndrome.
Dushianthan A, Cusack R, Grocott MPW, Postle AD
J Lipid Res 2018 Jun;59(6):1034-1045. Epub 2018 May 1 doi: 10.1194/jlr.P085050. PMID: 29716960Free PMC Article
Homocysteine, intracellular signaling and thrombotic disorders.
Dionisio N, Jardín I, Salido GM, Rosado JA
Curr Med Chem 2010;17(27):3109-19. doi: 10.2174/092986710791959783. PMID: 20629621
Methods for measuring sulfur amino acid metabolism.
Hoffer LJ
Curr Opin Clin Nutr Metab Care 2002 Sep;5(5):511-7. doi: 10.1097/00075197-200209000-00009. PMID: 12172474
The effect of a subnormal vitamin B-6 status on homocysteine metabolism.
Ubbink JB, van der Merwe A, Delport R, Allen RH, Stabler SP, Riezler R, Vermaak WJ
J Clin Invest 1996 Jul 1;98(1):177-84. doi: 10.1172/JCI118763. PMID: 8690790Free PMC Article

Diagnosis

Circulating surfactant protein D is decreased in early rheumatoid arthritis: a 1-year prospective study.
Hoegh SV, Lindegaard HM, Sorensen GL, Høj A, Bendixen C, Junker P, Holmskov U
Scand J Immunol 2008 Jan;67(1):71-6. doi: 10.1111/j.1365-3083.2007.02039.x. PMID: 18052966
Is an elevated circulating maternal homocysteine concentration a risk factor for neural tube defects?
Ubbink JB
Nutr Rev 1995 Jun;53(6):173-5. doi: 10.1111/j.1753-4887.1995.tb01546.x. PMID: 7478313
Plasma beta-endorphin, but not met-enkephalin levels are abnormal in chronic alcoholics.
Vescovi PP, Coiro V, Volpi R, Giannini A, Passeri M
Alcohol Alcohol 1992 Sep;27(5):471-5. PMID: 1335722

Therapy

Targeted metabolomic analysis of serum amino acids in the adult Fontan patient with a dominant left ventricle.
Michel M, Dubowy KO, Entenmann A, Karall D, Adam MG, Zlamy M, Odri Komazec I, Geiger R, Niederwanger C, Salvador C, Müller U, Laser KT, Scholl-Bürgi S
Sci Rep 2020 Jun 2;10(1):8930. doi: 10.1038/s41598-020-65852-x. PMID: 32488174Free PMC Article
The effect of a subnormal vitamin B-6 status on homocysteine metabolism.
Ubbink JB, van der Merwe A, Delport R, Allen RH, Stabler SP, Riezler R, Vermaak WJ
J Clin Invest 1996 Jul 1;98(1):177-84. doi: 10.1172/JCI118763. PMID: 8690790Free PMC Article
Irreversibly sickled erythrocytes: a consequence of the heterogeneous distribution of hemoglobin types in sickle-cell anemia.
Bertles JF, Milner PF
J Clin Invest 1968 Aug;47(8):1731-41. doi: 10.1172/JCI105863. PMID: 5666109Free PMC Article

Prognosis

Circulating surfactant protein D is decreased in early rheumatoid arthritis: a 1-year prospective study.
Hoegh SV, Lindegaard HM, Sorensen GL, Høj A, Bendixen C, Junker P, Holmskov U
Scand J Immunol 2008 Jan;67(1):71-6. doi: 10.1111/j.1365-3083.2007.02039.x. PMID: 18052966
Methods for measuring sulfur amino acid metabolism.
Hoffer LJ
Curr Opin Clin Nutr Metab Care 2002 Sep;5(5):511-7. doi: 10.1097/00075197-200209000-00009. PMID: 12172474
Irreversibly sickled erythrocytes: a consequence of the heterogeneous distribution of hemoglobin types in sickle-cell anemia.
Bertles JF, Milner PF
J Clin Invest 1968 Aug;47(8):1731-41. doi: 10.1172/JCI105863. PMID: 5666109Free PMC Article

Clinical prediction guides

Methods for measuring sulfur amino acid metabolism.
Hoffer LJ
Curr Opin Clin Nutr Metab Care 2002 Sep;5(5):511-7. doi: 10.1097/00075197-200209000-00009. PMID: 12172474
Increased membrane-protein methylation in hereditary spherocytosis. A marker of cytoskeletal disarray.
Ingrosso D, D'Angelo S, Perna AF, Iolascon A, Miraglia del Giudice E, Perrotta S, Zappia V, Galletti P
Eur J Biochem 1995 Mar 15;228(3):894-8. doi: 10.1111/j.1432-1033.1995.tb20337.x. PMID: 7737191
Plasma beta-endorphin, but not met-enkephalin levels are abnormal in chronic alcoholics.
Vescovi PP, Coiro V, Volpi R, Giannini A, Passeri M
Alcohol Alcohol 1992 Sep;27(5):471-5. PMID: 1335722
Irreversibly sickled erythrocytes: a consequence of the heterogeneous distribution of hemoglobin types in sickle-cell anemia.
Bertles JF, Milner PF
J Clin Invest 1968 Aug;47(8):1731-41. doi: 10.1172/JCI105863. PMID: 5666109Free PMC Article

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