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Symphalangism of the 3rd finger

MedGen UID:
869927
•Concept ID:
C4024358
•
Anatomical Abnormality
Synonym: Fused middle finger
 
HPO: HP:0009445

Definition

Fusion of two or more bones of the 3rd finger. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSymphalangism of the 3rd finger

Recent clinical studies

Etiology

Interconnection between Mixed-Handedness, Digit Ratios and Hand and Foot Minor Anomalies in Predicting Schizophrenia.
Babovic SS, Srdic Galic BD, Krstonosic BS, Petricevic SD, Siladji DS, Ralevic S, Babic SM, Novakovic AD, Stilinovic NP
Psychiatr Danub 2022 Fall;34(3):431-438. doi: 10.24869/psyd.2022.431. PMID: 36256980
Radiographic Characteristics of the Hand in Apert Syndrome.
Kracoff SL
J Hand Surg Asian Pac Vol 2020 Mar;25(1):82-86. doi: 10.1142/S2424835520500113. PMID: 32000596
ORAL-FACIAL-DIGITAL SYNDROME TYPE I (CLINICAL CASE).
Horlenko O, Lenchenko A, Kossey G, Tomey A, Debretseni O
Georgian Med News 2018 Dec;(285):47-51. PMID: 30702069
Normative data for anthropometric parameters used in delineation of dysmorphic features in north Indian children.
Kapoor S, Bhuhsan S, Ghosh VB, Pandey RM, Kalaivani M
Indian J Pediatr 2012 May;79(5):619-31. Epub 2011 Nov 9 doi: 10.1007/s12098-011-0572-0. PMID: 22069166
Autosomal dominant syndrome of camptodactyly, clinodactyly, syndactyly, and bifid toes.
Malik S, Afzal M, Gul S, Wahab A, Ahmad M
Am J Med Genet A 2010 Sep;152A(9):2313-7. doi: 10.1002/ajmg.a.33552. PMID: 20683984

Diagnosis

Interconnection between Mixed-Handedness, Digit Ratios and Hand and Foot Minor Anomalies in Predicting Schizophrenia.
Babovic SS, Srdic Galic BD, Krstonosic BS, Petricevic SD, Siladji DS, Ralevic S, Babic SM, Novakovic AD, Stilinovic NP
Psychiatr Danub 2022 Fall;34(3):431-438. doi: 10.24869/psyd.2022.431. PMID: 36256980
ORAL-FACIAL-DIGITAL SYNDROME TYPE I (CLINICAL CASE).
Horlenko O, Lenchenko A, Kossey G, Tomey A, Debretseni O
Georgian Med News 2018 Dec;(285):47-51. PMID: 30702069
Autosomal Recessive Oculodentodigital Dysplasia: A Case Report and Review of the Literature.
Taşdelen E, Durmaz CD, Karabulut HG
Cytogenet Genome Res 2018;154(4):181-186. Epub 2018 Jun 15 doi: 10.1159/000489000. PMID: 29902798
Gastrointestinal manifestations in diploid/triploid mixoploidy.
Lalani FK, Elsner GL, Lebel RR, Beg MB
J Pediatr Gastroenterol Nutr 2015 Jun;60(6):799-801. doi: 10.1097/MPG.0000000000000622. PMID: 25373857
Manifestations in four males with and an obligate carrier of the Lenz microphthalmia syndrome.
Forrester S, Kovach MJ, Reynolds NM, Urban R, Kimonis V
Am J Med Genet 2001 Jan 1;98(1):92-100. PMID: 11426460

Therapy

Radiographic Characteristics of the Hand in Apert Syndrome.
Kracoff SL
J Hand Surg Asian Pac Vol 2020 Mar;25(1):82-86. doi: 10.1142/S2424835520500113. PMID: 32000596
ORAL-FACIAL-DIGITAL SYNDROME TYPE I (CLINICAL CASE).
Horlenko O, Lenchenko A, Kossey G, Tomey A, Debretseni O
Georgian Med News 2018 Dec;(285):47-51. PMID: 30702069
Multiple malformations in a male and maternal osteopathia strata with cranial sclerosis (OSCS).
Rott HD, Krieg P, Rütschle H, Kraus C
Genet Couns 2003;14(3):281-8. PMID: 14577672
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Prognosis

Interconnection between Mixed-Handedness, Digit Ratios and Hand and Foot Minor Anomalies in Predicting Schizophrenia.
Babovic SS, Srdic Galic BD, Krstonosic BS, Petricevic SD, Siladji DS, Ralevic S, Babic SM, Novakovic AD, Stilinovic NP
Psychiatr Danub 2022 Fall;34(3):431-438. doi: 10.24869/psyd.2022.431. PMID: 36256980
A heterozygous duplication variant of the HOXD13 gene caused synpolydactyly type 1 with variable expressivity in a Chinese family.
Zaib T, Ji W, Saleem K, Nie G, Li C, Cao L, Xu B, Dong K, Yu H, Hao X, Xue Y, Si S, Jia X, Wu J, Zhang X, Guan R, Ji G, Bai J, Chen F, Liu Y, Sun W, Fu S
BMC Med Genet 2019 Dec 23;20(1):203. doi: 10.1186/s12881-019-0908-6. PMID: 31870337Free PMC Article
Autosomal dominant syndrome of camptodactyly, clinodactyly, syndactyly, and bifid toes.
Malik S, Afzal M, Gul S, Wahab A, Ahmad M
Am J Med Genet A 2010 Sep;152A(9):2313-7. doi: 10.1002/ajmg.a.33552. PMID: 20683984

Clinical prediction guides

Interconnection between Mixed-Handedness, Digit Ratios and Hand and Foot Minor Anomalies in Predicting Schizophrenia.
Babovic SS, Srdic Galic BD, Krstonosic BS, Petricevic SD, Siladji DS, Ralevic S, Babic SM, Novakovic AD, Stilinovic NP
Psychiatr Danub 2022 Fall;34(3):431-438. doi: 10.24869/psyd.2022.431. PMID: 36256980
A heterozygous duplication variant of the HOXD13 gene caused synpolydactyly type 1 with variable expressivity in a Chinese family.
Zaib T, Ji W, Saleem K, Nie G, Li C, Cao L, Xu B, Dong K, Yu H, Hao X, Xue Y, Si S, Jia X, Wu J, Zhang X, Guan R, Ji G, Bai J, Chen F, Liu Y, Sun W, Fu S
BMC Med Genet 2019 Dec 23;20(1):203. doi: 10.1186/s12881-019-0908-6. PMID: 31870337Free PMC Article
Normative data for anthropometric parameters used in delineation of dysmorphic features in north Indian children.
Kapoor S, Bhuhsan S, Ghosh VB, Pandey RM, Kalaivani M
Indian J Pediatr 2012 May;79(5):619-31. Epub 2011 Nov 9 doi: 10.1007/s12098-011-0572-0. PMID: 22069166
A case of symbrachydactyly with oligodactyly.
Seven M, Yuksel A, Ozkilic A
Genet Couns 2001;12(1):77-83. PMID: 11332981
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

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