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Abnormal ossification of the pubic bone

MedGen UID:
870163
•Concept ID:
C4024596
•
Anatomical Abnormality
Synonym: Abnormal maturation of the pubic bone
 
HPO: HP:0009105

Definition

Abnormal ossification (bone tissue formation) affecting the pubic bone, also known as the pubis. [from HPO]

Professional guidelines

PubMed

The Pubic Diastasis Measurement, a Key Element for the Diagnosis, Management, and Prognosis of the Bladder Exstrophy.
Antomarchi J, Moeglin D, Laurichesse H, Combourieu D, Bigi N, Maisonneuve E, Legac P, Althuser M, Delotte J, Jouannic JM, Bongain A
Fetal Diagn Ther 2019;45(6):435-440. Epub 2018 Sep 19 doi: 10.1159/000492817. PMID: 30231253

Recent clinical studies

Etiology

The Pubic Diastasis Measurement, a Key Element for the Diagnosis, Management, and Prognosis of the Bladder Exstrophy.
Antomarchi J, Moeglin D, Laurichesse H, Combourieu D, Bigi N, Maisonneuve E, Legac P, Althuser M, Delotte J, Jouannic JM, Bongain A
Fetal Diagn Ther 2019;45(6):435-440. Epub 2018 Sep 19 doi: 10.1159/000492817. PMID: 30231253
Contribution of three-dimensional computed tomography in the assessment of fetal skeletal dysplasia.
Cassart M, Massez A, Cos T, Tecco L, Thomas D, Van Regemorter N, Avni F
Ultrasound Obstet Gynecol 2007 May;29(5):537-43. doi: 10.1002/uog.4001. PMID: 17444568
Synostosis between pubic bones due to neurogenic, heterotopic ossification.
Vaidyanathan S, Hughes PL, Soni BM
ScientificWorldJournal 2006 Oct 2;6:2486-90. doi: 10.1100/tsw.2006.387. PMID: 17619722Free PMC Article
The non-ossified pubis.
Cortina H, Vallcanera A, Andres V, Gracia A, Aparici R, Mari A
Pediatr Radiol 1979 Apr 19;8(2):87-92. doi: 10.1007/BF00973997. PMID: 221875

Diagnosis

The Pubic Diastasis Measurement, a Key Element for the Diagnosis, Management, and Prognosis of the Bladder Exstrophy.
Antomarchi J, Moeglin D, Laurichesse H, Combourieu D, Bigi N, Maisonneuve E, Legac P, Althuser M, Delotte J, Jouannic JM, Bongain A
Fetal Diagn Ther 2019;45(6):435-440. Epub 2018 Sep 19 doi: 10.1159/000492817. PMID: 30231253
Report of second case and clinical and molecular characterization of Eiken syndrome.
Moirangthem A, Narayanan DL, Jacob P, Nishimura G, Mortier G, Girisha KM
Clin Genet 2018 Nov;94(5):457-460. Epub 2018 Jul 27 doi: 10.1111/cge.13413. PMID: 29987841
Bone formation following lenalidomide-dexamethasone combination therapy in cases of multiple myeloma refractory to high-dose chemotherapy with bortezomib and autologous peripheral blood stem cell transplantation: report of a case and review of the literature.
Sekiguchi Y, Ichikawa K, Wakabayashi M, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M
Int J Clin Exp Pathol 2015;8(8):9609-19. Epub 2015 Aug 1 PMID: 26464727Free PMC Article
Clinical and radiological findings in Pallister-Killian syndrome.
Jamuar S, Lai A, Unger S, Nishimura G
Eur J Med Genet 2012 Mar;55(3):167-72. Epub 2012 Feb 10 doi: 10.1016/j.ejmg.2012.01.019. PMID: 22387057
Contribution of three-dimensional computed tomography in the assessment of fetal skeletal dysplasia.
Cassart M, Massez A, Cos T, Tecco L, Thomas D, Van Regemorter N, Avni F
Ultrasound Obstet Gynecol 2007 May;29(5):537-43. doi: 10.1002/uog.4001. PMID: 17444568

Therapy

Bone formation following lenalidomide-dexamethasone combination therapy in cases of multiple myeloma refractory to high-dose chemotherapy with bortezomib and autologous peripheral blood stem cell transplantation: report of a case and review of the literature.
Sekiguchi Y, Ichikawa K, Wakabayashi M, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M
Int J Clin Exp Pathol 2015;8(8):9609-19. Epub 2015 Aug 1 PMID: 26464727Free PMC Article
Failed methotrexate termination of pregnancy: a case report.
Goffman D, Cole DS, Bobby P, Garry DJ
J Perinatol 2006 Oct;26(10):645-7. doi: 10.1038/sj.jp.7211563. PMID: 17006526
Distraction osteogenesis (callotasis) for pelvic closure in bladder exstrophy.
Kandemir U, Yazici M, Tokgozoglu AM, Alanay A
Clin Orthop Relat Res 2004 Jan;(418):231-6. doi: 10.1097/00003086-200401000-00040. PMID: 15043123

Prognosis

The Pubic Diastasis Measurement, a Key Element for the Diagnosis, Management, and Prognosis of the Bladder Exstrophy.
Antomarchi J, Moeglin D, Laurichesse H, Combourieu D, Bigi N, Maisonneuve E, Legac P, Althuser M, Delotte J, Jouannic JM, Bongain A
Fetal Diagn Ther 2019;45(6):435-440. Epub 2018 Sep 19 doi: 10.1159/000492817. PMID: 30231253
Expanding spectrum of congenital disorder of glycosylation Ig (CDG-Ig): sibs with a unique skeletal dysplasia, hypogammaglobulinemia, cardiomyopathy, genital malformations, and early lethality.
Kranz C, Basinger AA, Güçsavaş-Calikoğlu M, Sun L, Powell CM, Henderson FW, Aylsworth AS, Freeze HH
Am J Med Genet A 2007 Jun 15;143A(12):1371-8. doi: 10.1002/ajmg.a.31791. PMID: 17506107
Cerebro-osseous-digital syndrome: four new cases of a lethal skeletal dysplasia--distinct from Neu-Laxova Syndrome.
Elliott AM, Gonzales M, Hoeffel JC, Le Merrer M, Maroteaux P, Encha-Razavi F, Joye N, Berchel C, Fliegel C, Aughton DJ, Beaudry-Rodgers K, Hasteh F, Nerlich AG, Wilcox WR, Rimoin DL, Lachman RS, Freisinger P
Am J Med Genet 2002 Apr 22;109(2):139-48. doi: 10.1002/ajmg.10324. PMID: 11977163
Sclerotic changes of the manubrium sterni.
Jurik AG, Graudal H, de Carvalho A
Skeletal Radiol 1985;13(3):195-201. doi: 10.1007/BF00350573. PMID: 3158077

Clinical prediction guides

Report of second case and clinical and molecular characterization of Eiken syndrome.
Moirangthem A, Narayanan DL, Jacob P, Nishimura G, Mortier G, Girisha KM
Clin Genet 2018 Nov;94(5):457-460. Epub 2018 Jul 27 doi: 10.1111/cge.13413. PMID: 29987841
Synostosis between pubic bones due to neurogenic, heterotopic ossification.
Vaidyanathan S, Hughes PL, Soni BM
ScientificWorldJournal 2006 Oct 2;6:2486-90. doi: 10.1100/tsw.2006.387. PMID: 17619722Free PMC Article
Failed methotrexate termination of pregnancy: a case report.
Goffman D, Cole DS, Bobby P, Garry DJ
J Perinatol 2006 Oct;26(10):645-7. doi: 10.1038/sj.jp.7211563. PMID: 17006526
Periacetabular and intertrochanteric osteotomy for the treatment of osteoarthrosis in dysplastic hips.
Trousdale RT, Ekkernkamp A, Ganz R, Wallrichs SL
J Bone Joint Surg Am 1995 Jan;77(1):73-85. doi: 10.2106/00004623-199501000-00010. PMID: 7822358
The non-ossified pubis.
Cortina H, Vallcanera A, Andres V, Gracia A, Aparici R, Mari A
Pediatr Radiol 1979 Apr 19;8(2):87-92. doi: 10.1007/BF00973997. PMID: 221875

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