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Olivary degeneration

MedGen UID:
870267
•Concept ID:
C4024707
•
Disease or Syndrome; Finding
Synonyms: Degeneration, Olivary; Degeneration, Olivary Nucleus; Olivary Degeneration; Olivary Degenerations; Olivary Nucleus Degeneration; Olivary Nucleus Degenerations
 
HPO: HP:0008303

Definition

Degeneration of the olivary bodies, prominent oval structures in the medulla oblongata. [from HPO]

Professional guidelines

PubMed

Successful treatment of paroxysmal painful tonic spasms with carbamazepine in a patient with hypertrophic olivary degeneration.
Fiore A, Florindo I, Zinno L, Pavarani A, Chierici E
Neurol Sci 2023 Jan;44(1):373-375. Epub 2022 Sep 9 doi: 10.1007/s10072-022-06383-3. PMID: 36075999
Differential diagnosis of T2 hyperintense brainstem lesions: Part 1. Focal lesions.
Guzmán-De-Villoria JA, Fernández-García P, Ferreiro-Argüelles C
Semin Ultrasound CT MR 2010 Jun;31(3):246-59. doi: 10.1053/j.sult.2010.03.001. PMID: 20483392

Recent clinical studies

Etiology

Structural damage burden and hypertrophic olivary degeneration in pediatric postoperative cerebellar mutism syndrome.
Beez T, Munoz-Bendix C, Mijderwijk HJ, Remke M, Hänggi D
Neurosurg Rev 2022 Aug;45(4):2757-2765. Epub 2022 Apr 20 doi: 10.1007/s10143-022-01791-7. PMID: 35441993Free PMC Article
Hypertrophic olivary degeneration: A clinico-radiologic study.
Konno T, Broderick DF, Tacik P, Caviness JN, Wszolek ZK
Parkinsonism Relat Disord 2016 Jul;28:36-40. Epub 2016 Apr 12 doi: 10.1016/j.parkreldis.2016.04.008. PMID: 27132500Free PMC Article
MRI Findings in Nonlesional Hypertrophic Olivary Degeneration.
Gu CN, Carr CM, Kaufmann TJ, Kotsenas AL, Hunt CH, Wood CP
J Neuroimaging 2015 Sep-Oct;25(5):813-7. Epub 2015 Jun 15 doi: 10.1111/jon.12267. PMID: 26073621
Bilateral hypertrophic olivary nucleus degeneration on magnetic resonance imaging in children with Leigh and Leigh-like syndrome.
Bindu PS, Taly AB, Sonam K, Govindaraju C, Arvinda HR, Gayathri N, Bharath MM, Ranjith D, Nagappa M, Sinha S, Khan NA, Thangaraj K
Br J Radiol 2014 Feb;87(1034):20130478. doi: 10.1259/bjr.20130478. PMID: 24470583Free PMC Article
Hypertrophic olivary degeneration following surgical resection or gamma knife radiosurgery of brainstem cavernous malformations: an 11-case series and a review of literature.
Yun JH, Ahn JS, Park JC, Kwon DH, Kwun BD, Kim CJ
Acta Neurochir (Wien) 2013 Mar;155(3):469-76. Epub 2012 Dec 6 doi: 10.1007/s00701-012-1567-y. PMID: 23224379

Diagnosis

The Guillain-Mollaret triangle: a key player in motor coordination and control with implications for neurological disorders.
Ogut E, Armagan K, Tufekci D
Neurosurg Rev 2023 Jul 20;46(1):181. doi: 10.1007/s10143-023-02086-1. PMID: 37468768
Palatal myoclonus and hypertrophic olivary degeneration following wernekinck commissure syndrome: a case report.
Zhang Q, Guo J, Zhao X, Zhang X, Ma Y
BMC Neurol 2023 Mar 29;23(1):127. doi: 10.1186/s12883-023-03157-y. PMID: 36991344Free PMC Article
Holmes tremor: an updated review.
Pyrgelis ES, Agapiou E, Angelopoulou E
Neurol Sci 2022 Dec;43(12):6731-6740. Epub 2022 Aug 25 doi: 10.1007/s10072-022-06352-w. PMID: 36006552
Hypertrophic olivary degeneration: A comprehensive review focusing on etiology.
Wang H, Wang Y, Wang R, Li Y, Wang P, Li J, Du J
Brain Res 2019 Sep 1;1718:53-63. Epub 2019 Apr 23 doi: 10.1016/j.brainres.2019.04.024. PMID: 31026459
Hypertrophic olivary degeneration: Case series and review of literature.
Sabat S, Mannering N, Agarwal A
J Neurol Sci 2016 Nov 15;370:180-186. Epub 2016 Sep 28 doi: 10.1016/j.jns.2016.09.055. PMID: 27772756

Therapy

Bilateral Hypertrophic Olivary Degeneration as a Paraneoplastic Syndrome of a Poorly Differentiated Carcinoma of the Upper Gastrointestinal Tract: A Case Report and Literature Review.
Daneshmand A, Borhani-Haghighi A, Monabati A, Karimi M, Ostovan VR
Neurologist 2022 Nov 1;27(6):357-360. doi: 10.1097/NRL.0000000000000414. PMID: 35051964
Transient Palatal Tremor and Action Induced Foot and Leg Dystonia due to Hypertrophic Olivary Degeneration: a Case Report.
Yang J, Yang J, Li B, Bao L
J Stroke Cerebrovasc Dis 2020 Oct;29(10):105147. Epub 2020 Jul 30 doi: 10.1016/j.jstrokecerebrovasdis.2020.105147. PMID: 32912540
Olivary hypertrophy improved by steroid treatment: Two case reports with unique presentations.
Ohara M, Sanjo N, Hattori T, Oyama J, Hamada M, Ozaki K, Yokota T
J Neuroimmunol 2019 Sep 15;334:577003. Epub 2019 Jul 5 doi: 10.1016/j.jneuroim.2019.577003. PMID: 31306854
Hypertrophic olivary degeneration resulting from posterior fossa masses and their treatments.
Hirano M, Hatzoglou V, Karimi S, Young RJ
Clin Imaging 2015 Sep-Oct;39(5):787-90. Epub 2015 Jun 3 doi: 10.1016/j.clinimag.2015.05.015. PMID: 26104225Free PMC Article
MR imaging evaluation of inferior olivary nuclei: comparison of postoperative subjects with and without posterior fossa syndrome.
Patay Z, Enterkin J, Harreld JH, Yuan Y, Löbel U, Rumboldt Z, Khan R, Boop F
AJNR Am J Neuroradiol 2014 Apr;35(4):797-802. Epub 2013 Nov 1 doi: 10.3174/ajnr.A3762. PMID: 24184519Free PMC Article

Prognosis

The Guillain-Mollaret triangle: a key player in motor coordination and control with implications for neurological disorders.
Ogut E, Armagan K, Tufekci D
Neurosurg Rev 2023 Jul 20;46(1):181. doi: 10.1007/s10143-023-02086-1. PMID: 37468768
Structural damage burden and hypertrophic olivary degeneration in pediatric postoperative cerebellar mutism syndrome.
Beez T, Munoz-Bendix C, Mijderwijk HJ, Remke M, Hänggi D
Neurosurg Rev 2022 Aug;45(4):2757-2765. Epub 2022 Apr 20 doi: 10.1007/s10143-022-01791-7. PMID: 35441993Free PMC Article
A meta-analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarction.
Wang YL, Gao Y, He PP, Yin JN, Dong RF, Li X, Fu Y, Zhang H
J Integr Neurosci 2020 Sep 30;19(3):507-511. doi: 10.31083/j.jin.2020.03.1238. PMID: 33070531
Hypertrophic Olivary Degeneration: Neurosurgical Perspective and Literature Review.
Onen MR, Moore K, Cikla U, Ucer M, Schmidt B, Field AS, Baskaya MK
World Neurosurg 2018 Apr;112:e763-e771. Epub 2018 Jan 31 doi: 10.1016/j.wneu.2018.01.150. PMID: 29382617
Hypertrophic olivary degeneration following surgical resection or gamma knife radiosurgery of brainstem cavernous malformations: an 11-case series and a review of literature.
Yun JH, Ahn JS, Park JC, Kwon DH, Kwun BD, Kim CJ
Acta Neurochir (Wien) 2013 Mar;155(3):469-76. Epub 2012 Dec 6 doi: 10.1007/s00701-012-1567-y. PMID: 23224379

Clinical prediction guides

Structural damage burden and hypertrophic olivary degeneration in pediatric postoperative cerebellar mutism syndrome.
Beez T, Munoz-Bendix C, Mijderwijk HJ, Remke M, Hänggi D
Neurosurg Rev 2022 Aug;45(4):2757-2765. Epub 2022 Apr 20 doi: 10.1007/s10143-022-01791-7. PMID: 35441993Free PMC Article
Hypertrophic Olivary Degeneration: Neurosurgical Perspective and Literature Review.
Onen MR, Moore K, Cikla U, Ucer M, Schmidt B, Field AS, Baskaya MK
World Neurosurg 2018 Apr;112:e763-e771. Epub 2018 Jan 31 doi: 10.1016/j.wneu.2018.01.150. PMID: 29382617
Hypertrophic olivary degeneration: A clinico-radiologic study.
Konno T, Broderick DF, Tacik P, Caviness JN, Wszolek ZK
Parkinsonism Relat Disord 2016 Jul;28:36-40. Epub 2016 Apr 12 doi: 10.1016/j.parkreldis.2016.04.008. PMID: 27132500Free PMC Article
Postoperative posterior fossa syndrome: unraveling the etiology and underlying pathophysiology by using magnetic resonance imaging.
Patay Z
Childs Nerv Syst 2015 Oct;31(10):1853-8. Epub 2015 Jul 5 doi: 10.1007/s00381-015-2796-1. PMID: 26143277
Hypertrophic olivary degeneration following surgical resection or gamma knife radiosurgery of brainstem cavernous malformations: an 11-case series and a review of literature.
Yun JH, Ahn JS, Park JC, Kwon DH, Kwun BD, Kim CJ
Acta Neurochir (Wien) 2013 Mar;155(3):469-76. Epub 2012 Dec 6 doi: 10.1007/s00701-012-1567-y. PMID: 23224379

Recent systematic reviews

The Guillain-Mollaret triangle: a key player in motor coordination and control with implications for neurological disorders.
Ogut E, Armagan K, Tufekci D
Neurosurg Rev 2023 Jul 20;46(1):181. doi: 10.1007/s10143-023-02086-1. PMID: 37468768

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