U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spinous keratoses of palms and soles

MedGen UID:
870385
•Concept ID:
C4024830
•
Disease or Syndrome
HPO: HP:0007613

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpinous keratoses of palms and soles

Conditions with this feature

Punctate palmoplantar keratoderma type 2
MedGen UID:
356886
•Concept ID:
C1867982
•
Disease or Syndrome
A type of isolated punctate hereditary palmoplantar keratoderma with characteristics of multiple asymptomatic 1 to 2 mm-long, firm, hyperkeratotic projections (spiny keratosis) on the palms, soles and digits (typically confined to their volar and/or lateral aspects). Histopathologically compact columnar parakeratosis over hypo or agranular epidermis is observed.
See: Condition Record
Punctate palmoplantar keratoderma type 2

Recent clinical studies

Etiology

Arginine in the beginning of the 1A rod domain of the keratin 10 gene is the hot spot for the mutation in epidermolytic hyperkeratosis.
Yang JM, Nam K, Kim SW, Jung SY, Min HG, Yeo UC, Park KB, Lee JH, Suhr KB, Park JK, Lee ES
J Dermatol Sci 1999 Feb;19(2):126-33. doi: 10.1016/s0923-1811(98)00055-3. PMID: 10098704

Diagnosis

Generalized epidermolytic ichthyosis with palmoplantar hyperkeratosis.
Putra PB, Radiono S, Danarti R
Dermatol Online J 2021 Feb 15;27(2) PMID: 33818988
Abnormal keratinization and cutaneous inflammation in Mal de Meleda.
Kudo M, Ishiura N, Tamura-Nakano M, Shimizu T, Kamata M, Akasaka E, Nakano H, Okuma Y, Tada Y, Okochi H, Tamaki T
J Dermatol 2020 May;47(5):554-558. Epub 2020 Mar 10 doi: 10.1111/1346-8138.15296. PMID: 32157724
Richner-Hanhart's syndrome: new ultrastructural observations on skin lesions of two cases.
el-Shoura SM, Tallab TM
Ultrastruct Pathol 1997 Jan-Feb;21(1):51-6. doi: 10.3109/01913129709023247. PMID: 9029766

Therapy

Keratoderma hereditaria mutilans. Etretinate treatment and electron microscope studies.
Palungwachira P, Iwahara K, Ogawa H
Australas J Dermatol 1992;33(1):19-30. doi: 10.1111/j.1440-0960.1992.tb00048.x. PMID: 1445089

Prognosis

Abnormal keratinization and cutaneous inflammation in Mal de Meleda.
Kudo M, Ishiura N, Tamura-Nakano M, Shimizu T, Kamata M, Akasaka E, Nakano H, Okuma Y, Tada Y, Okochi H, Tamaki T
J Dermatol 2020 May;47(5):554-558. Epub 2020 Mar 10 doi: 10.1111/1346-8138.15296. PMID: 32157724

Clinical prediction guides

Generalized epidermolytic ichthyosis with palmoplantar hyperkeratosis.
Putra PB, Radiono S, Danarti R
Dermatol Online J 2021 Feb 15;27(2) PMID: 33818988
Abnormal keratinization and cutaneous inflammation in Mal de Meleda.
Kudo M, Ishiura N, Tamura-Nakano M, Shimizu T, Kamata M, Akasaka E, Nakano H, Okuma Y, Tada Y, Okochi H, Tamaki T
J Dermatol 2020 May;47(5):554-558. Epub 2020 Mar 10 doi: 10.1111/1346-8138.15296. PMID: 32157724
Ultrastructural features of ichthyosis hystrix strongly resembling Lambert type.
Wang WH, Li LF, Zhang Q, Yang SM, Jiang W, Wang YY, Lei PC, Chen XR
Br J Dermatol 2007 May;156(5):1027-31. Epub 2007 Mar 13 doi: 10.1111/j.1365-2133.2007.07792.x. PMID: 17355236
Richner-Hanhart's syndrome: new ultrastructural observations on skin lesions of two cases.
el-Shoura SM, Tallab TM
Ultrastruct Pathol 1997 Jan-Feb;21(1):51-6. doi: 10.3109/01913129709023247. PMID: 9029766
Keratoderma hereditaria mutilans. Etretinate treatment and electron microscope studies.
Palungwachira P, Iwahara K, Ogawa H
Australas J Dermatol 1992;33(1):19-30. doi: 10.1111/j.1440-0960.1992.tb00048.x. PMID: 1445089

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...