U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Paresis of extensor muscles of the big toe

MedGen UID:
871217
Concept ID:
C4025696
Finding
HPO: HP:0002601

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParesis of extensor muscles of the big toe

Conditions with this feature

Neuronopathy, distal hereditary motor, type 2A
MedGen UID:
322471
Concept ID:
C1834692
Disease or Syndrome
Distal hereditary motor neuropathy, type II is a progressive disorder that affects nerve cells in the spinal cord. It results in muscle weakness and affects movement, primarily in the legs.\n\nOnset of distal hereditary motor neuropathy, type II ranges from the teenage years through mid-adulthood. The initial symptoms of the disorder are cramps or weakness in the muscles of the big toe and later, the entire foot. Over a period of approximately 5 to 10 years, affected individuals experience a gradual loss of muscle tissue (atrophy) in the lower legs. They begin to have trouble walking and running, and eventually may have complete paralysis of the lower legs. The thigh muscles may also be affected, although generally this occurs later and is less severe.\n\nSome individuals with distal hereditary motor neuropathy, type II have weakening of the muscles in the hands and forearms. This weakening is less pronounced than in the lower limbs and does not usually result in paralysis.
Neuronopathy, distal hereditary motor, type 2B
MedGen UID:
382017
Concept ID:
C2608087
Disease or Syndrome
Some individuals with distal hereditary motor neuropathy, type II have weakening of the muscles in the hands and forearms. This weakening is less pronounced than in the lower limbs and does not usually result in paralysis.\n\nOnset of distal hereditary motor neuropathy, type II ranges from the teenage years through mid-adulthood. The initial symptoms of the disorder are cramps or weakness in the muscles of the big toe and later, the entire foot. Over a period of approximately 5 to 10 years, affected individuals experience a gradual loss of muscle tissue (atrophy) in the lower legs. They begin to have trouble walking and running, and eventually may have complete paralysis of the lower legs. The thigh muscles may also be affected, although generally this occurs later and is less severe.\n\nDistal hereditary motor neuropathy, type II is a progressive disorder that affects nerve cells in the spinal cord. It results in muscle weakness and affects movement, primarily in the legs.

Recent clinical studies

Etiology

Jönsson B, Strömqvist B
Spine (Phila Pa 1976) 1995 Sep 15;20(18):2012-5. doi: 10.1097/00007632-199509150-00012. PMID: 8578378
Adams RW, Gandevia SC, Skuse NF
Brain 1990 Oct;113 ( Pt 5):1459-76. doi: 10.1093/brain/113.5.1459. PMID: 2245306

Diagnosis

Ferbert A, Zibat A, Rautenstrauß B, Kress W, Hügens-Penzel M, Weis J, Shah Y, Roth C
Neuromuscul Disord 2016 Sep;26(9):598-603. Epub 2016 Jun 22 doi: 10.1016/j.nmd.2016.06.458. PMID: 27469267
Dallari D, Pellacani A, Marinelli A, Verni E, Giunti A
J Sports Med Phys Fitness 2004 Dec;44(4):436-40. PMID: 15758858
Jönsson B, Strömqvist B
Spine (Phila Pa 1976) 1995 Sep 15;20(18):2012-5. doi: 10.1097/00007632-199509150-00012. PMID: 8578378

Prognosis

Ferbert A, Zibat A, Rautenstrauß B, Kress W, Hügens-Penzel M, Weis J, Shah Y, Roth C
Neuromuscul Disord 2016 Sep;26(9):598-603. Epub 2016 Jun 22 doi: 10.1016/j.nmd.2016.06.458. PMID: 27469267
Jönsson B, Strömqvist B
Spine (Phila Pa 1976) 1995 Sep 15;20(18):2012-5. doi: 10.1097/00007632-199509150-00012. PMID: 8578378

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...