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Skin infiltrative basal cell carcinoma

MedGen UID:
87201
•Concept ID:
C0334257
•
Neoplastic Process
Synonyms: Basal cell carcinoma, desmoplastic type; Infiltrating Basal Cell Carcinoma; Infiltrating basal cell carcinoma; infiltrating basal cell carcinoma; Infiltrating basal cell carcinoma, non-sclerosing; Infiltrating basal cell carcinoma, sclerosing; infiltrative basal cell carcinoma; Skin Infiltrating Basal Cell Carcinoma; skin infiltrating basal cell carcinoma; skin infiltrative basal cell carcinoma
SNOMED CT: Infiltrating basal cell carcinoma, sclerosing (56665009); Infiltrating basal cell carcinoma, non-sclerosing (56665009); Basal cell carcinoma, desmoplastic type (56665009); Infiltrating basal cell carcinoma (56665009)
 
Monarch Initiative: MONDO:0002953

Definition

A variant of basal cell carcinoma presenting as a pale, indurated plaque, usually in the upper trunk or face. Morphologically, it is characterized by the presence of strands, cords, and columns of basaloid cells infiltrating the dermis. Perineural invasion may be present and the basaloid cell infiltrate may extend into deeper tissues. [from NCI]

Professional guidelines

PubMed

Face and Scalp Basal Cell Carcinoma Treatment: A Review of the Literature.
Bernardini N, Skroza N, Zuber S, Tolino E, Balduzzi V, Mambrin A, Marchesiello A, Anzalone A, Colapietra D, Proietti I, Potenza C
Acta Dermatovenerol Croat 2019 Mar;27(1):22-27. PMID: 31032787
Diagnosis and Management of Basal Cell Carcinoma.
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Management of periorbital basal cell carcinoma with orbital invasion.
Sun MT, Wu A, Figueira E, Huilgol S, Selva D
Future Oncol 2015 Nov;11(22):3003-10. Epub 2015 Oct 5 doi: 10.2217/fon.15.190. PMID: 26437207

Recent clinical studies

Etiology

Matrix metalloproteinases in keratinocyte carcinomas.
Riihilä P, Nissinen L, Kähäri VM
Exp Dermatol 2021 Jan;30(1):50-61. Epub 2020 Sep 17 doi: 10.1111/exd.14183. PMID: 32869366Free PMC Article
Face and Scalp Basal Cell Carcinoma Treatment: A Review of the Literature.
Bernardini N, Skroza N, Zuber S, Tolino E, Balduzzi V, Mambrin A, Marchesiello A, Anzalone A, Colapietra D, Proietti I, Potenza C
Acta Dermatovenerol Croat 2019 Mar;27(1):22-27. PMID: 31032787
Diagnosis and Management of Basal Cell Carcinoma.
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Basosquamous carcinoma.
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364
Lichen sclerosus.
Yesudian PD, Sugunendran H, Bates CM, O'Mahony C
Int J STD AIDS 2005 Jul;16(7):465-73, test 474. doi: 10.1258/0956462054308440. PMID: 16004624

Diagnosis

Diagnosis and Management of Basal Cell Carcinoma.
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Current diagnosis and treatment of basal cell carcinoma.
Alter M, Hillen U, Leiter U, Sachse M, Gutzmer R
J Dtsch Dermatol Ges 2015 Sep;13(9):863-74; quiz 875. doi: 10.1111/ddg.12798. PMID: 26882375
Perioral dermatitis.
Lipozenčić J, Hadžavdić SL
Clin Dermatol 2014 Jan-Feb;32(1):125-30. doi: 10.1016/j.clindermatol.2013.05.034. PMID: 24314386
Perioral dermatitis.
Lipozencic J, Ljubojevic S
Clin Dermatol 2011 Mar-Apr;29(2):157-61. doi: 10.1016/j.clindermatol.2010.09.007. PMID: 21396555
Basosquamous carcinoma.
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364

Therapy

Dermoscopic features of basal cell carcinoma and its subtypes: A systematic review.
Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA
J Am Acad Dermatol 2021 Sep;85(3):653-664. Epub 2019 Nov 7 doi: 10.1016/j.jaad.2019.11.008. PMID: 31706938Free PMC Article
Diagnosis and Management of Basal Cell Carcinoma.
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Current diagnosis and treatment of basal cell carcinoma.
Alter M, Hillen U, Leiter U, Sachse M, Gutzmer R
J Dtsch Dermatol Ges 2015 Sep;13(9):863-74; quiz 875. doi: 10.1111/ddg.12798. PMID: 26882375
Perioral dermatitis.
Lipozenčić J, Hadžavdić SL
Clin Dermatol 2014 Jan-Feb;32(1):125-30. doi: 10.1016/j.clindermatol.2013.05.034. PMID: 24314386
Perioral dermatitis.
Lipozencic J, Ljubojevic S
Clin Dermatol 2011 Mar-Apr;29(2):157-61. doi: 10.1016/j.clindermatol.2010.09.007. PMID: 21396555

Prognosis

Incidence and trends of basal cell carcinoma in Sweden: a population-based registry study.
Kappelin J, Green AC, Ingvar Å, Ahnlide I, Nielsen K
Br J Dermatol 2022 Jun;186(6):963-969. Epub 2022 Apr 3 doi: 10.1111/bjd.20964. PMID: 34939666
Skin Cancer: Squamous and Basal Cell Carcinomas.
Bashline B
FP Essent 2019 Jun;481:17-22. PMID: 31188548
Diagnosis and Management of Basal Cell Carcinoma.
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Basosquamous carcinoma.
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364
Lichen sclerosus.
Yesudian PD, Sugunendran H, Bates CM, O'Mahony C
Int J STD AIDS 2005 Jul;16(7):465-73, test 474. doi: 10.1258/0956462054308440. PMID: 16004624

Clinical prediction guides

Exploring multisite heterogeneity of human basal cell carcinoma proteome and transcriptome.
Berl A, Shir-Az O, Genish I, Biran H, Mann D, Singh A, Wise J, Kravtsov V, Kidron D, Golberg A, Vitkin E, Yakhini Z, Shalom A
PLoS One 2023;18(11):e0293744. Epub 2023 Nov 10 doi: 10.1371/journal.pone.0293744. PMID: 37948379Free PMC Article
Histologically Agressive Basal Cell Carcinoma With Particular Emphasis On Galeal Infiltration Of The Scalp.
Requena C, Serra-Guillén C, Sanmartín O
Actas Dermosifiliogr 2022 Jun;113(6):575-582. Epub 2022 Feb 12 doi: 10.1016/j.ad.2022.01.026. PMID: 35339267
Metastatic head and neck cutaneous basal cell carcinomas: a retrospective observational study.
Furlan K, Reddy V, Alabkaa A, Rohra P, Mir F, Gattuso P
Arch Dermatol Res 2021 Aug;313(6):439-443. Epub 2020 Aug 10 doi: 10.1007/s00403-020-02120-y. PMID: 32776227
Fibroepithelioma of Pinkus.
Bartos V, Pokorny D, Zacharova O, Kullova M, Adamicova K, Pec M
Bratisl Lek Listy 2012;113(10):624-7. doi: 10.4149/bll_2012_142. PMID: 23094905
Basosquamous carcinoma.
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364

Recent systematic reviews

Dermoscopic features of basal cell carcinoma and its subtypes: A systematic review.
Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA
J Am Acad Dermatol 2021 Sep;85(3):653-664. Epub 2019 Nov 7 doi: 10.1016/j.jaad.2019.11.008. PMID: 31706938Free PMC Article
Exfoliative cytology for diagnosing basal cell carcinoma and other skin cancers in adults.
Ferrante di Ruffano L, Dinnes J, Chuchu N, Bayliss SE, Takwoingi Y, Davenport C, Matin RN, O'Sullivan C, Roskell D, Deeks JJ, Williams HC; Cochrane Skin Cancer Diagnostic Test Accuracy Group
Cochrane Database Syst Rev 2018 Dec 4;12(12):CD013187. doi: 10.1002/14651858.CD013187. PMID: 30521689Free PMC Article
Photodynamic therapy and pain: A systematic review.
Ang JM, Riaz IB, Kamal MU, Paragh G, Zeitouni NC
Photodiagnosis Photodyn Ther 2017 Sep;19:308-344. Epub 2017 Jul 15 doi: 10.1016/j.pdpdt.2017.07.002. PMID: 28716738
Giant Basal Cell Carcinomas Express Neuroactive Mediators and Show a High Growth Rate: A Case-Control Study and Meta-Analysis of Etiopathogenic and Prognostic Factors.
Yazdani Abyaneh MA, Engel P, Slominski A, Ragsdale B, Agag R, Cramer D, Carlson JA
Am J Dermatopathol 2017 Mar;39(3):189-194. doi: 10.1097/DAD.0000000000000640. PMID: 27759693Free PMC Article
Topical imiquimod or fluorouracil therapy for basal and squamous cell carcinoma: a systematic review.
Love WE, Bernhard JD, Bordeaux JS
Arch Dermatol 2009 Dec;145(12):1431-8. doi: 10.1001/archdermatol.2009.291. PMID: 20026854

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