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Multiple Adenomatous Polyps

MedGen UID:
87211
•Concept ID:
C0334294
•
Neoplastic Process
Synonyms: Adenomatosis; Gastrointestinal Tract Multiple Adenomatous Polyps; GI Tract Multiple Adenomatous Polyps; Multiple adenomatous polyps
SNOMED CT: Multiple adenomatous polyps (6379007); Adenomatosis (70921007)

Definition

A condition in which multiple adenomas develop in the gastrointestinal tract. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultiple Adenomatous Polyps

Professional guidelines

PubMed

Clinical utility gene card for: MUTYH-associated polyposis (MAP), autosomal recessive colorectal adenomatous polyposis, multiple colorectal adenomas, multiple adenomatous polyps (MAP) - update 2012.
Aretz S, Genuardi M, Hes FJ
Eur J Hum Genet 2013 Jan;21(1) Epub 2012 Aug 8 doi: 10.1038/ejhg.2012.163. PMID: 22872101Free PMC Article
The clinical [corrected] background of familial adenomatous polyposis. History, epidemiology, diagnosis and treatment.
Kartheuser A, Detry R, West S, Coppens JP, Gribomont AC, Hoang P, Melange M, Vanheuverzwyn R, Verellen-Dumoulin C, Burn J
Acta Gastroenterol Belg 1995 Mar-Apr;58(2):252-66. PMID: 7571988

Recent clinical studies

Etiology

Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp Phenotype.
Xie LJ, Ruan DD, Zhang JH, Li Y, Chen L, Yan ML, Yu MD, Luo JW, Zhang HZ
Can J Gastroenterol Hepatol 2021;2021:6610434. Epub 2021 Apr 12 doi: 10.1155/2021/6610434. PMID: 33954154Free PMC Article
Surgical treatment of familial adenomatous polyposis: dilemmas and current recommendations.
Campos FG
World J Gastroenterol 2014 Nov 28;20(44):16620-9. doi: 10.3748/wjg.v20.i44.16620. PMID: 25469031Free PMC Article
Korean type 2 diabetes patients have multiple adenomatous polyps compared to non-diabetic controls.
Suh S, Kang M, Kim MY, Chung HS, Kim SK, Hur KY, Kim JH, Lee MS, Lee MK, Kim KW
J Korean Med Sci 2011 Sep;26(9):1196-200. Epub 2011 Sep 1 doi: 10.3346/jkms.2011.26.9.1196. PMID: 21935276Free PMC Article
The genetics of FAP and FAP-like syndromes.
Lipton L, Tomlinson I
Fam Cancer 2006;5(3):221-6. doi: 10.1007/s10689-005-5673-3. PMID: 16998667
The association of multiple colonic adenomatous polyps with cancer of the colon.
Schuman BM, Simsek H, Lyons RC
Am J Gastroenterol 1990 Jul;85(7):846-9. PMID: 2371985

Diagnosis

Surgical treatment of familial adenomatous polyposis: dilemmas and current recommendations.
Campos FG
World J Gastroenterol 2014 Nov 28;20(44):16620-9. doi: 10.3748/wjg.v20.i44.16620. PMID: 25469031Free PMC Article
Ganglioneuromatous polyposis of the colon in a patient with multiple adenomatous polyps.
Sayki Arslan M, Ekız F, Yilmaz G, Çoban Ş, Savaş B, Ensarı A, Örmecı N
Turk J Gastroenterol 2012;23(6):780-3. PMID: 23864455
Korean type 2 diabetes patients have multiple adenomatous polyps compared to non-diabetic controls.
Suh S, Kang M, Kim MY, Chung HS, Kim SK, Hur KY, Kim JH, Lee MS, Lee MK, Kim KW
J Korean Med Sci 2011 Sep;26(9):1196-200. Epub 2011 Sep 1 doi: 10.3346/jkms.2011.26.9.1196. PMID: 21935276Free PMC Article
The clinical [corrected] background of familial adenomatous polyposis. History, epidemiology, diagnosis and treatment.
Kartheuser A, Detry R, West S, Coppens JP, Gribomont AC, Hoang P, Melange M, Vanheuverzwyn R, Verellen-Dumoulin C, Burn J
Acta Gastroenterol Belg 1995 Mar-Apr;58(2):252-66. PMID: 7571988
The association of multiple colonic adenomatous polyps with cancer of the colon.
Schuman BM, Simsek H, Lyons RC
Am J Gastroenterol 1990 Jul;85(7):846-9. PMID: 2371985

Therapy

Surgical treatment of familial adenomatous polyposis: dilemmas and current recommendations.
Campos FG
World J Gastroenterol 2014 Nov 28;20(44):16620-9. doi: 10.3748/wjg.v20.i44.16620. PMID: 25469031Free PMC Article

Prognosis

Constitutional Mismatch Repair Gene Defect Syndrome Presenting With Adenomatous Polyposis and Cafe au Lait Spots: A Case Report.
Sağ E, Erkut M, Saygin İ, Çebi AH, Bahadir A, Erduran E, Saruhan H, Cakir M
J Pediatr Hematol Oncol 2020 Oct;42(7):e689-e691. doi: 10.1097/MPH.0000000000001614. PMID: 31599855
Congenital hypertrophy of retinal pigment epithelium (CHRPE) in patients with familial adenomatous polyposis (FAP); a polyposis registry experience.
Nusliha A, Dalpatadu U, Amarasinghe B, Chandrasinghe PC, Deen KI
BMC Res Notes 2014 Oct 18;7:734. doi: 10.1186/1756-0500-7-734. PMID: 25326340Free PMC Article
Clinical utility gene card for: MUTYH-associated polyposis (MAP), autosomal recessive colorectal adenomatous polyposis, multiple colorectal adenomas, multiple adenomatous polyps (MAP) - update 2012.
Aretz S, Genuardi M, Hes FJ
Eur J Hum Genet 2013 Jan;21(1) Epub 2012 Aug 8 doi: 10.1038/ejhg.2012.163. PMID: 22872101Free PMC Article
Influence of non-alcoholic fatty liver disease on the prognosis in patients with colorectal cancer.
Min YW, Yun HS, Chang WI, Kim JY, Kim YH, Son HJ, Kim JJ, Rhee JC, Chang DK
Clin Res Hepatol Gastroenterol 2012 Feb;36(1):78-83. Epub 2011 Nov 30 doi: 10.1016/j.clinre.2011.10.006. PMID: 22133576
Colorectal cancer screening using stool DNA analysis in clinical practice: early clinical experience with respect to patient acceptance and colonoscopic follow-up of abnormal tests.
Berger BM, Schroy PC 3rd, Rosenberg JL, Lai-Goldman M, Eisenberg M, Brown T, Rochelle RB, Billings PR
Clin Colorectal Cancer 2006 Jan;5(5):338-43. doi: 10.3816/CCC.2006.n.003. PMID: 16512992

Clinical prediction guides

Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp Phenotype.
Xie LJ, Ruan DD, Zhang JH, Li Y, Chen L, Yan ML, Yu MD, Luo JW, Zhang HZ
Can J Gastroenterol Hepatol 2021;2021:6610434. Epub 2021 Apr 12 doi: 10.1155/2021/6610434. PMID: 33954154Free PMC Article
Congenital hypertrophy of retinal pigment epithelium (CHRPE) in patients with familial adenomatous polyposis (FAP); a polyposis registry experience.
Nusliha A, Dalpatadu U, Amarasinghe B, Chandrasinghe PC, Deen KI
BMC Res Notes 2014 Oct 18;7:734. doi: 10.1186/1756-0500-7-734. PMID: 25326340Free PMC Article
Clinical utility gene card for: MUTYH-associated polyposis (MAP), autosomal recessive colorectal adenomatous polyposis, multiple colorectal adenomas, multiple adenomatous polyps (MAP) - update 2012.
Aretz S, Genuardi M, Hes FJ
Eur J Hum Genet 2013 Jan;21(1) Epub 2012 Aug 8 doi: 10.1038/ejhg.2012.163. PMID: 22872101Free PMC Article
Influence of non-alcoholic fatty liver disease on the prognosis in patients with colorectal cancer.
Min YW, Yun HS, Chang WI, Kim JY, Kim YH, Son HJ, Kim JJ, Rhee JC, Chang DK
Clin Res Hepatol Gastroenterol 2012 Feb;36(1):78-83. Epub 2011 Nov 30 doi: 10.1016/j.clinre.2011.10.006. PMID: 22133576
The identical 5' splice-site acceptor mutation in five attenuated APC families from Newfoundland demonstrates a founder effect.
Spirio L, Green J, Robertson J, Robertson M, Otterud B, Sheldon J, Howse E, Green R, Groden J, White R, Leppert M
Hum Genet 1999 Nov;105(5):388-98. doi: 10.1007/s004390051121. PMID: 10598803

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