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Adenocarcinoma with Apocrine Metaplasia

MedGen UID:
87234
•Concept ID:
C0334396
•
Neoplastic Process
Synonyms: Adenocarcinoma with apocrine metaplasia; Carcinoma with apocrine metaplasia
SNOMED CT: Adenocarcinoma with apocrine metaplasia (22694002); Carcinoma with apocrine metaplasia (22694002)

Definition

An invasive adenocarcinoma characterized by focal or extensive transformation of the malignant glandular cells to cells with abundant, usually granular eosinophilic cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma with Apocrine Metaplasia

Professional guidelines

PubMed

Disease Behavior and Treatment Response of Special Histological Types of Triple-Negative Breast Cancer.
Bonadio RC, Costa FA, Mendes SV, Araujo BJ, Nader-Marta G, Pinto PBC, Batista DN, Testa L, Ferrari MS
Clin Breast Cancer 2022 Dec;22(8):e892-e900. Epub 2022 Aug 20 doi: 10.1016/j.clbc.2022.08.006. PMID: 36130851
Histopathology of nonspecific granulomatous prostatitis with special reference to eosinophilic epithelial metaplasia: Pathophysiologic, diagnostic and differential diagnostic correlations.
Dikov DI, Koleva MS, Boivin JF, Lisner T, Belovezhdov VT, Sarafian V
Indian J Pathol Microbiol 2020 Feb;63(Supplement):S34-S40. doi: 10.4103/IJPM.IJPM_568_18. PMID: 32108624
ASCUS and AGUS criteria. International Academy of Cytology Task Force summary. Diagnostic Cytology Towards the 21st Century: An International Expert Conference and Tutorial.
Solomon D, Frable WJ, Vooijs GP, Wilbur DC, Amma NS, Collins RJ, Davey DD, Knight BK, Luff RD, Meisels A, Navin J, Rosenthal DL, Sauer T, Stoler M, Suprun HZ, Yamauchi K
Acta Cytol 1998 Jan-Feb;42(1):16-24. doi: 10.1159/000331531. PMID: 9479320

Recent clinical studies

Etiology

Disease Behavior and Treatment Response of Special Histological Types of Triple-Negative Breast Cancer.
Bonadio RC, Costa FA, Mendes SV, Araujo BJ, Nader-Marta G, Pinto PBC, Batista DN, Testa L, Ferrari MS
Clin Breast Cancer 2022 Dec;22(8):e892-e900. Epub 2022 Aug 20 doi: 10.1016/j.clbc.2022.08.006. PMID: 36130851
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Molecular phenotyping reveals the identity of Barrett's esophagus and its malignant transition.
Nowicki-Osuch K, Zhuang L, Jammula S, Bleaney CW, Mahbubani KT, Devonshire G, Katz-Summercorn A, Eling N, Wilbrey-Clark A, Madissoon E, Gamble J, Di Pietro M, O'Donovan M, Meyer KB, Saeb-Parsy K, Sharrocks AD, Teichmann SA, Marioni JC, Fitzgerald RC
Science 2021 Aug 13;373(6556):760-767. doi: 10.1126/science.abd1449. PMID: 34385390
Eosinophilic metaplasia in transurethral resection of the prostate.
Koleva MS, Dikov DI, Belovezhdov VT, Sarafian V
Indian J Pathol Microbiol 2020 Jul-Sep;63(3):423-426. doi: 10.4103/IJPM.IJPM_593_19. PMID: 32769332
Apocrine carcinoma vs. apocrine metaplasia with atypia of the breast. Use of aspiration biopsy cytology.
Yoshida K, Inoue M, Furuta S, Sakai R, Imai R, Hayakawa S, Fukatsu T, Nagasaka T, Nakashima N
Acta Cytol 1996 Mar-Apr;40(2):247-51. doi: 10.1159/000333746. PMID: 8629406

Diagnosis

Top Ten Oncocytic Head and Neck Lesions to Contemplate.
Bullock MJ, Jiang XS
Head Neck Pathol 2023 Mar;17(1):53-65. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01520-y. PMID: 36928735Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Benign mimics of prostatic adenocarcinoma.
Trpkov K
Mod Pathol 2018 Jan;31(S1):S22-46. doi: 10.1038/modpathol.2017.136. PMID: 29297489
Mucinous and secondary tumors of the prostate.
Osunkoya AO
Mod Pathol 2018 Jan;31(S1):S80-S95. doi: 10.1038/modpathol.2017.132. PMID: 29297488
Syringometaplasia: variants and underlying mechanisms.
Abbas O, Bhawan J
Int J Dermatol 2016 Feb;55(2):142-8. Epub 2015 Oct 13 doi: 10.1111/ijd.13040. PMID: 26460811

Therapy

Poor histologic tumor response after adjuvant therapy in basal-like HER2-positive breast carcinoma.
Zhao D, Fu X, Rohr J, Wang Y, Li M, Zhang X, Qin J, Xu M, Li C, Sun G, Wang Z, Guo S
Pathol Res Pract 2021 Dec;228:153677. Epub 2021 Oct 30 doi: 10.1016/j.prp.2021.153677. PMID: 34775151
Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers.
Zhang Y, Zheng D, Zhou T, Song H, Hulsurkar M, Su N, Liu Y, Wang Z, Shao L, Ittmann M, Gleave M, Han H, Xu F, Liao W, Wang H, Li W
Nat Commun 2018 Oct 4;9(1):4080. doi: 10.1038/s41467-018-06177-2. PMID: 30287808Free PMC Article
Exuberant Squamous Metaplasia with Calcification Following Intraoperative Radiotherapy for Breast Carcinoma: Report of an Unusual Case and Retrospective Review of Cases from a Single Institution.
Ginter PS, Ng J, Zhuo R, Swistel AJ, D'Alfonso TM
Breast J 2017 May;23(3):267-274. Epub 2016 Nov 30 doi: 10.1111/tbj.12733. PMID: 27900811
Lymphatic Vascularization in Prostate Adenocarcinoma: Correlation with Tumor Grade, Androgen Withdrawal and Prognosis.
Ambrosio MR, Rocca BJ, Barone A, Ginori A, Crivelli F, Pirtoli L, Del Vecchio MT
Anticancer Res 2015 Oct;35(10):5595-600. PMID: 26408731
Effect of combination endocrine therapy (LHRH agonist and flutamide) on normal prostate and prostatic adenocarcinoma. A histopathologic and immunohistochemical study.
Têtu B, Srigley JR, Boivin JC, Dupont A, Monfette G, Pinault S, Labrie F
Am J Surg Pathol 1991 Feb;15(2):111-20. doi: 10.1097/00000478-199102000-00002. PMID: 1989458

Prognosis

Disease Behavior and Treatment Response of Special Histological Types of Triple-Negative Breast Cancer.
Bonadio RC, Costa FA, Mendes SV, Araujo BJ, Nader-Marta G, Pinto PBC, Batista DN, Testa L, Ferrari MS
Clin Breast Cancer 2022 Dec;22(8):e892-e900. Epub 2022 Aug 20 doi: 10.1016/j.clbc.2022.08.006. PMID: 36130851
Eccrine ductal and acrosyringeal metaplasia in breast carcinomas: report of eight cases.
Tot T
Virchows Arch 2019 Mar;474(3):383-387. Epub 2018 Nov 22 doi: 10.1007/s00428-018-2488-9. PMID: 30467599
Mucinous and secondary tumors of the prostate.
Osunkoya AO
Mod Pathol 2018 Jan;31(S1):S80-S95. doi: 10.1038/modpathol.2017.132. PMID: 29297488
Lymphatic Vascularization in Prostate Adenocarcinoma: Correlation with Tumor Grade, Androgen Withdrawal and Prognosis.
Ambrosio MR, Rocca BJ, Barone A, Ginori A, Crivelli F, Pirtoli L, Del Vecchio MT
Anticancer Res 2015 Oct;35(10):5595-600. PMID: 26408731
Myoepithelial cells in salivary gland tumors--revisited.
Dardick I, van Nostrand AW
Head Neck Surg 1985 May-Jun;7(5):395-408. doi: 10.1002/hed.2890070509. PMID: 2833468

Clinical prediction guides

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
α-Methylacyl-CoA racemase: a useful immunohistochemical marker of breast carcinoma with apocrine differentiation.
Nakamura H, Kukita Y, Kunimasa K, Kittaka N, Kusama H, Nakayama T, Tamaki Y, Sugiura R, Yasuda H, Hashimoto M, Yamamoto T, Imamura F, Nakatsuka SI
Hum Pathol 2021 Oct;116:39-48. Epub 2021 Jul 24 doi: 10.1016/j.humpath.2021.07.005. PMID: 34314764
Own experience in the treatment of major salivary gland tumors.
Jałocha-Kaczka A, Kolary-Siekierska K, Miłoński J, Olszewski J
Otolaryngol Pol 2020 Feb 5;74(3):17-22. doi: 10.5604/01.3001.0013.6605. PMID: 32398385
Infarcted Warthin tumor with mucoepidermoid carcinoma-like metaplasia: a case report and review of the literature.
Yorita K, Nakagawa H, Miyazaki K, Fukuda J, Ito S, Kosai M
J Med Case Rep 2019 Jan 14;13(1):12. doi: 10.1186/s13256-018-1941-3. PMID: 30636634Free PMC Article
Syringometaplasia: variants and underlying mechanisms.
Abbas O, Bhawan J
Int J Dermatol 2016 Feb;55(2):142-8. Epub 2015 Oct 13 doi: 10.1111/ijd.13040. PMID: 26460811

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