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Mixed Tumor of the Parotid Gland

MedGen UID:
87507
•Concept ID:
C0345604
•
Neoplastic Process
Synonyms: Mixed parotid tumor; Mixed Tumor of Parotid Gland
SNOMED CT: Mixed parotid tumor (254463006)

Definition

A benign or malignant neoplasm that arises from the parotid gland. It is characterized by the presence of epithelial and mesenchymal elements. This category includes pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and carcinosarcoma. [from NCI]

Professional guidelines

PubMed

Treatment of relapses of benign latero-cervical pathology: a narrative literature review.
Meliante PG, Colizza A, Ralli M, Minni A, Angeletti D, Cambria F, de Vincentiis M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl 1):S76-S83. doi: 10.14639/0392-100X-suppl.1-43-2023-10. PMID: 37698104Free PMC Article
Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Recent clinical studies

Etiology

Risk of Carcinoma in Pleomorphic Adenomas of the Parotid.
Levyn H, Subramanian T, Eagan A, Katabi N, Lin O, Badillo ND, Martinez G, Scholfield DW, Wong RJ, Shah JP, Givi B, Morris LGT, Ganly I, Patel SG
JAMA Otolaryngol Head Neck Surg 2023 Nov 1;149(11):1034-1041. doi: 10.1001/jamaoto.2023.3212. PMID: 37824134Free PMC Article
Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Histopathological comparison of pleomorphic adenomas of the parotid and submandibular gland.
Mantsopoulos K, Sievert M, Iro AK, Müller SK, Koch M, Schapher M, Agaimy A, Iro H
Oral Dis 2022 May;28(4):1131-1136. Epub 2021 Apr 5 doi: 10.1111/odi.13858. PMID: 33772981
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Diagnosis

Pleomorphic adenoma of the parotid gland.
Middleton H, Strelow B
JAAPA 2022 Sep 1;35(9):54-56. doi: 10.1097/01.JAA.0000854504.04227.cf. PMID: 36007120
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Salivary glands.
Silvers AR, Som PM
Radiol Clin North Am 1998 Sep;36(5):941-66, vi. doi: 10.1016/s0033-8389(05)70070-1. PMID: 9747195
Outpatient parotidectomy.
Steckler RM
Am J Surg 1991 Oct;162(4):303-5. doi: 10.1016/0002-9610(91)90136-2. PMID: 1659241
Salivary glands.
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

Therapy

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands.
Talwar A, Patel E, Tam M, Zhou F, Hu K, Persky M, Vaezi A, Jacobson A, Givi B
Otolaryngol Head Neck Surg 2023 Apr;168(4):775-781. Epub 2023 Jan 29 doi: 10.1177/01945998221120646. PMID: 35998038
Benign tumors of the superficial lobe of the parotid gland.
Ştefănescu EH, Mogoantă CA, Căluianu EI, Predescu OI, Florou C, Chercotă V, Iovănescu G
Rom J Morphol Embryol 2022 Jul-Sep;63(3):563-567. doi: 10.47162/RJME.63.3.11. PMID: 36588495Free PMC Article
Current thinking about the management of recurrent pleomorphic adenoma of the parotid: a structured review.
Kanatas A, Ho MWS, Mücke T
Br J Oral Maxillofac Surg 2018 May;56(4):243-248. Epub 2018 Mar 8 doi: 10.1016/j.bjoms.2018.01.021. PMID: 29526342
Proteomics analysis of pleomorphic adenoma of the human parotid gland.
Mutlu A, Ozturk M, Akpinar G, Kasap M, Kanli A
Eur Arch Otorhinolaryngol 2017 Aug;274(8):3183-3195. Epub 2017 May 11 doi: 10.1007/s00405-017-4608-6. PMID: 28497265
Functional superficial parotidectomy.
Zhao K, Qi DY, Wang LM
J Oral Maxillofac Surg 1994 Oct;52(10):1038-41. PMID: 8089788

Prognosis

Parotid incidentalomas: a systematic review.
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Basal Cell Adenoma of the Parotid Gland.
Amalanathan S , Kumar CS , Sinhasan SP
Kathmandu Univ Med J (KUMJ) 2020 Oct.-Dec.;18(72):434-436. PMID: 34165108
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Clinical prediction guides

Risk of Carcinoma in Pleomorphic Adenomas of the Parotid.
Levyn H, Subramanian T, Eagan A, Katabi N, Lin O, Badillo ND, Martinez G, Scholfield DW, Wong RJ, Shah JP, Givi B, Morris LGT, Ganly I, Patel SG
JAMA Otolaryngol Head Neck Surg 2023 Nov 1;149(11):1034-1041. doi: 10.1001/jamaoto.2023.3212. PMID: 37824134Free PMC Article
Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Histopathological comparison of pleomorphic adenomas of the parotid and submandibular gland.
Mantsopoulos K, Sievert M, Iro AK, Müller SK, Koch M, Schapher M, Agaimy A, Iro H
Oral Dis 2022 May;28(4):1131-1136. Epub 2021 Apr 5 doi: 10.1111/odi.13858. PMID: 33772981
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Recent systematic reviews

Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Parotid incidentalomas: a systematic review.
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Multiparametric magnetic resonance imaging of parotid tumors: A systematic review.
Coudert H, Mirafzal S, Dissard A, Boyer L, Montoriol PF
Diagn Interv Imaging 2021 Mar;102(3):121-130. Epub 2020 Sep 14 doi: 10.1016/j.diii.2020.08.002. PMID: 32943368
Intraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases.
Palicelli A
APMIS 2020 Mar;128(3):191-200. Epub 2020 Jan 3 doi: 10.1111/apm.13009. PMID: 31697865

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