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Benign neoplasm of thymus

MedGen UID:
87526
•Concept ID:
C0345975
•
Neoplastic Process
Synonyms: Benign Neoplasm of the Thymus; benign neoplasm of the Thymus; Benign Neoplasm of Thymus; benign neoplasm of thymus; Benign Thymic Neoplasm; benign thymic neoplasm; Benign Thymic Tumor; benign thymic tumor; benign thymic tumour; Benign Thymus Neoplasm; benign Thymus neoplasm; Benign Thymus Tumor; benign Thymus tumor; benign Thymus tumour; Benign Tumor of the Thymus; benign tumor of the Thymus; Benign tumor of thymus; Benign Tumor of Thymus; benign tumor of Thymus; benign tumour of the Thymus; benign tumour of Thymus; thymus benign neoplasm
SNOMED CT: Benign tumor of thymus (92437008); Benign neoplasm of thymus (92437008)
 
Monarch Initiative: MONDO:0021512

Definition

A non-metastasizing neoplasm that arises from the thymus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of thymus

Professional guidelines

PubMed

Update on the clinical management of multiple endocrine neoplasia type 1.
Pieterman CRC, Valk GD
Clin Endocrinol (Oxf) 2022 Oct;97(4):409-423. Epub 2022 Apr 1 doi: 10.1111/cen.14727. PMID: 35319130Free PMC Article
Primary Mediastinal B-Cell Lymphoma: A 2021 Update on Genetics, Diagnosis, and Novel Therapeutics.
Ahmed Z, Afridi SS, Shahid Z, Zamani Z, Rehman S, Aiman W, Khan M, Mir MA, Awan FT, Anwer F, Iftikhar R
Clin Lymphoma Myeloma Leuk 2021 Nov;21(11):e865-e875. Epub 2021 Jun 24 doi: 10.1016/j.clml.2021.06.012. PMID: 34330673
Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society.
Melzer N, Ruck T, Fuhr P, Gold R, Hohlfeld R, Marx A, Melms A, Tackenberg B, Schalke B, Schneider-Gold C, Zimprich F, Meuth SG, Wiendl H
J Neurol 2016 Aug;263(8):1473-94. Epub 2016 Feb 17 doi: 10.1007/s00415-016-8045-z. PMID: 26886206Free PMC Article

Recent clinical studies

Etiology

Obesity-induced thymic involution and cancer risk.
Lagou MK, Karagiannis GS
Semin Cancer Biol 2023 Aug;93:3-19. Epub 2023 Apr 22 doi: 10.1016/j.semcancer.2023.04.008. PMID: 37088128
Thymic Epithelial Neoplasms: Tumor-Node-Metastasis Staging.
Benveniste MFK, Betancourt Cuellar SL, Carter BW, Strange CD, Marom EM
Radiol Clin North Am 2021 Mar;59(2):183-192. doi: 10.1016/j.rcl.2020.11.006. PMID: 33551080
Thymic Epithelial Neoplasms: Radiologic-Pathologic Correlation.
Lichtenberger JP 3rd, Carter BW, Fisher DA, Parker RF, Peterson PG
Radiol Clin North Am 2021 Mar;59(2):169-182. Epub 2021 Jan 9 doi: 10.1016/j.rcl.2020.11.005. PMID: 33551079
T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies.
Vadillo E, Dorantes-Acosta E, Pelayo R, Schnoor M
Blood Rev 2018 Jan;32(1):36-51. Epub 2017 Aug 15 doi: 10.1016/j.blre.2017.08.006. PMID: 28830639
Imaging of thymic disorders.
Bogot NR, Quint LE
Cancer Imaging 2005 Dec 15;5(1):139-49. doi: 10.1102/1470-7330.2005.0107. PMID: 16361143Free PMC Article

Diagnosis

Thymic Epithelial Neoplasms: Tumor-Node-Metastasis Staging.
Benveniste MFK, Betancourt Cuellar SL, Carter BW, Strange CD, Marom EM
Radiol Clin North Am 2021 Mar;59(2):183-192. doi: 10.1016/j.rcl.2020.11.006. PMID: 33551080
Thymic Epithelial Neoplasms: Radiologic-Pathologic Correlation.
Lichtenberger JP 3rd, Carter BW, Fisher DA, Parker RF, Peterson PG
Radiol Clin North Am 2021 Mar;59(2):169-182. Epub 2021 Jan 9 doi: 10.1016/j.rcl.2020.11.005. PMID: 33551079
Non-Neoplastic and Benign Tumoral Lesions of the Thymic Gland: A Review and Update.
Hamza A, Weissferdt A
Adv Anat Pathol 2019 Jul;26(4):257-269. doi: 10.1097/PAP.0000000000000231. PMID: 30932971
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550
Thymic malignancies.
Loehrer PJ Sr, Wick MR
Cancer Treat Res 2001;105:277-302. doi: 10.1007/978-1-4615-1589-0_11. PMID: 11224991

Therapy

The journey from discoveries in fundamental immunology to cancer immunotherapy.
Miller JF, Sadelain M
Cancer Cell 2015 Apr 13;27(4):439-49. Epub 2015 Apr 6 doi: 10.1016/j.ccell.2015.03.007. PMID: 25858803
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550
Immunosenescence of ageing.
Gruver AL, Hudson LL, Sempowski GD
J Pathol 2007 Jan;211(2):144-56. doi: 10.1002/path.2104. PMID: 17200946Free PMC Article
Thymic malignancies.
Loehrer PJ Sr, Wick MR
Cancer Treat Res 2001;105:277-302. doi: 10.1007/978-1-4615-1589-0_11. PMID: 11224991
Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America.
Jaretzki A 3rd, Barohn RJ, Ernstoff RM, Kaminski HJ, Keesey JC, Penn AS, Sanders DB
Neurology 2000 Jul 12;55(1):16-23. doi: 10.1212/wnl.55.1.16. PMID: 10891897

Prognosis

Diagnosis and management of Intratyroid Ectopic Thymus.
Gazek N, Dujovne N, Ayarzábal V, Teplisky D, Herzovich V, Felipe L
Andes Pediatr 2021 Jun;92(3):406-410. doi: 10.32641/andespediatr.v92i3.3439. PMID: 34479247
Non-Neoplastic and Benign Tumoral Lesions of the Thymic Gland: A Review and Update.
Hamza A, Weissferdt A
Adv Anat Pathol 2019 Jul;26(4):257-269. doi: 10.1097/PAP.0000000000000231. PMID: 30932971
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies.
Vadillo E, Dorantes-Acosta E, Pelayo R, Schnoor M
Blood Rev 2018 Jan;32(1):36-51. Epub 2017 Aug 15 doi: 10.1016/j.blre.2017.08.006. PMID: 28830639
Tumors of the thymus.
Strollo DC, Rosado-de-Christenson ML
J Thorac Imaging 1999 Jul;14(3):152-71. doi: 10.1097/00005382-199907000-00002. PMID: 10404501

Clinical prediction guides

Obesity-induced thymic involution and cancer risk.
Lagou MK, Karagiannis GS
Semin Cancer Biol 2023 Aug;93:3-19. Epub 2023 Apr 22 doi: 10.1016/j.semcancer.2023.04.008. PMID: 37088128
Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus.
Payet CA, You A, Fayet OM, Hemery E, Truffault F, Bondet V, Duffy D, Michel F, Fadel E, Guihaire J, Demeret S, Berrih-Aknin S, Le Panse R
Ann Neurol 2023 Apr;93(4):643-654. Epub 2023 Jan 25 doi: 10.1002/ana.26590. PMID: 36571580
Thymus variants on imaging in patients with rheumatoid arthritis-clinical and immunological significance.
Murata O, Suzuki K, Sugiura H, Kondo Y, Takeshita M, Koga K, Takiguchi M, Kurisu R, Kassai Y, Yasuoka H, Yamaoka K, Morita R, Yoshimura A, Takeuchi T
Rheumatology (Oxford) 2021 Dec 1;60(12):5595-5600. doi: 10.1093/rheumatology/keab164. PMID: 33590850
Role of miRNAs in Normal and Myasthenia Gravis Thymus.
Cron MA, Guillochon É, Kusner L, Le Panse R
Front Immunol 2020;11:1074. Epub 2020 Jun 10 doi: 10.3389/fimmu.2020.01074. PMID: 32587589Free PMC Article
Thymoma.
Morgenthaler TI, Brown LR, Colby TV, Harper CM Jr, Coles DT
Mayo Clin Proc 1993 Nov;68(11):1110-23. doi: 10.1016/s0025-6196(12)60907-0. PMID: 8231276

Recent systematic reviews

Systematic Review of the Clinical Characteristics and Management of Isaac Syndrome.
Al-Chalabi M, Hegde P, Moore SR, Abouainain Y, Keener M, Parvez H, Eid J, Saleem S, Sheikh A
J Clin Neuromuscul Dis 2023 Dec 1;25(2):94-106. doi: 10.1097/CND.0000000000000460. PMID: 37962197
Surgical, Radiation, and Systemic Treatments of Patients With Thymic Epithelial Tumors: A Systematic Review.
Falkson CB, Vella ET, Ellis PM, Maziak DE, Ung YC, Yu E
J Thorac Oncol 2023 Mar;18(3):299-312. Epub 2022 Nov 4 doi: 10.1016/j.jtho.2022.10.016. PMID: 36343922
Characteristics of Good's Syndrome in China: A Systematic Review.
Dong JP, Gao W, Teng GG, Tian Y, Wang HH
Chin Med J (Engl) 2017 Jul 5;130(13):1604-1609. doi: 10.4103/0366-6999.208234. PMID: 28639577Free PMC Article
Thyroid disorders in polycystic ovary syndrome.
Kowalczyk K, Franik G, Kowalczyk D, Pluta D, Blukacz Ł, Madej P
Eur Rev Med Pharmacol Sci 2017 Jan;21(2):346-360. PMID: 28165551
The management of thymoma: a systematic review and practice guideline.
Falkson CB, Bezjak A, Darling G, Gregg R, Malthaner R, Maziak DE, Yu E, Smith CA, McNair S, Ung YC, Evans WK; Lung Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-Based Care
J Thorac Oncol 2009 Jul;4(7):911-9. doi: 10.1097/jto.0b013e3181a4b8e0. PMID: 19557895

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