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Lacrimal gland adenoid cystic carcinoma

MedGen UID:
87555
•Concept ID:
C0346340
•
Neoplastic Process
Synonyms: Adenoid cystic carcinoma of lacrimal gland; Adenoid Cystic Carcinoma of Lacrimal Gland; adenoid cystic carcinoma of lacrimal gland; Adenoid Cystic Carcinoma of the Lacrimal Gland; adenoid cystic carcinoma of the lacrimal gland; Lacrimal Gland Adenoid Cystic Carcinoma; lacrimal gland adenoid cystic carcinoma
SNOMED CT: Adenoid cystic carcinoma of lacrimal gland (254987003)
 
Monarch Initiative: MONDO:0006262

Definition

A carcinoma that arises from the lacrimal gland. It is characterized by the presence of malignant epithelial cells that form cribriform, tubular, and solid patterns. [from NCI]

Professional guidelines

PubMed

Multimodal therapy in the management of lacrimal gland adenoid cystic carcinoma.
Yang J, Zhou C, Wang Y, Fan X, Jia R
BMC Ophthalmol 2019 Jun 8;19(1):125. doi: 10.1186/s12886-019-1110-5. PMID: 31176360Free PMC Article
Current treatment of lacrimal gland carcinoma.
Woo KI, Kim YD, Sa HS, Esmaeli B
Curr Opin Ophthalmol 2016 Sep;27(5):449-56. doi: 10.1097/ICU.0000000000000301. PMID: 27273588
Microdissection genotyping analysis of the effect of intraarterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma.
Tse DT, Finkelstein SD, Benedetto P, Dubovy S, Schiffman J, Feuer WJ
Am J Ophthalmol 2006 Jan;141(1):54-61. doi: 10.1016/j.ajo.2005.09.002. PMID: 16386976

Recent clinical studies

Etiology

Neoadjuvant Intra-Arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma: A Long-Term Follow-up Study of a Trimodal Strategy.
Tse DT, Benedetto PW, Tse BC, Feuer WJ
Am J Ophthalmol 2022 Aug;240:239-251. Epub 2022 Apr 2 doi: 10.1016/j.ajo.2022.03.027. PMID: 35381201Free PMC Article
Multimodal therapy in the management of lacrimal gland adenoid cystic carcinoma.
Yang J, Zhou C, Wang Y, Fan X, Jia R
BMC Ophthalmol 2019 Jun 8;19(1):125. doi: 10.1186/s12886-019-1110-5. PMID: 31176360Free PMC Article
Current treatment of lacrimal gland carcinoma.
Woo KI, Kim YD, Sa HS, Esmaeli B
Curr Opin Ophthalmol 2016 Sep;27(5):449-56. doi: 10.1097/ICU.0000000000000301. PMID: 27273588
Neutron radiotherapy for adenoid cystic carcinoma of the lacrimal gland.
Gensheimer MF, Rainey D, Douglas JG, Liao JJ, Laramore GE, Jian-Amadi A, Chow LQ, Koh WJ, Parvathaneni U
Ophthalmic Plast Reconstr Surg 2013 Jul-Aug;29(4):256-60. doi: 10.1097/IOP.0b013e318295f99b. PMID: 23839633
Adenoid cystic carcinoma of the lacrimal gland: CT and MRI findings.
Qin W, Chong R, Huang X, Liu M, Yin ZQ
Eur J Ophthalmol 2012 May-Jun;22(3):316-9. doi: 10.5301/ejo.5000015. PMID: 21725943

Diagnosis

MiR-29a-3p inhibits high-grade transformation and epithelial-mesenchymal transition of lacrimal gland adenoid cystic carcinoma by targeting Quaking.
Xu F, Jiang M, Tang Q, Lin J, Liu X, Zhang C, Zhao J, He Y, Dong L, Zhu L, Lin T
Mol Biol Rep 2023 Mar;50(3):2305-2316. Epub 2022 Dec 28 doi: 10.1007/s11033-022-08150-1. PMID: 36575320
Prognostic impact of Notch1 receptor and clinicopathological High-Risk Predictors in lacrimal gland adenoid cystic carcinoma.
Anjum S, Sen S, Pushker N, Bajaj MS, Kashyap S, Bakhshi S, Chosdol K, Meel R, Sharma MC
Acta Ophthalmol 2021 Dec;99(8):e1467-e1473. Epub 2021 Mar 6 doi: 10.1111/aos.14812. PMID: 33675181
Multimodal therapy in the management of lacrimal gland adenoid cystic carcinoma.
Yang J, Zhou C, Wang Y, Fan X, Jia R
BMC Ophthalmol 2019 Jun 8;19(1):125. doi: 10.1186/s12886-019-1110-5. PMID: 31176360Free PMC Article
Long-Term Outcomes of Eye-Sparing Surgery for Adenoid Cystic Carcinoma of Lacrimal Gland.
Han J, Kim YD, Woo KI, Sobti D
Ophthalmic Plast Reconstr Surg 2018 Jan/Feb;34(1):74-78. doi: 10.1097/IOP.0000000000000877. PMID: 28221296
Adenoid cystic carcinoma of the lacrimal gland: CT and MRI findings.
Qin W, Chong R, Huang X, Liu M, Yin ZQ
Eur J Ophthalmol 2012 May-Jun;22(3):316-9. doi: 10.5301/ejo.5000015. PMID: 21725943

Therapy

Neoadjuvant Intra-Arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma: A Long-Term Follow-up Study of a Trimodal Strategy.
Tse DT, Benedetto PW, Tse BC, Feuer WJ
Am J Ophthalmol 2022 Aug;240:239-251. Epub 2022 Apr 2 doi: 10.1016/j.ajo.2022.03.027. PMID: 35381201Free PMC Article
Multimodal therapy in the management of lacrimal gland adenoid cystic carcinoma.
Yang J, Zhou C, Wang Y, Fan X, Jia R
BMC Ophthalmol 2019 Jun 8;19(1):125. doi: 10.1186/s12886-019-1110-5. PMID: 31176360Free PMC Article
Intra-arterial Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma.
Zhang M, Fathy C, Breazzano MP, Hollar M, Barahimi B
Int Ophthalmol Clin 2017 Winter;57(1):143-152. doi: 10.1097/IIO.0000000000000158. PMID: 27898620
Neutron radiotherapy for adenoid cystic carcinoma of the lacrimal gland.
Gensheimer MF, Rainey D, Douglas JG, Liao JJ, Laramore GE, Jian-Amadi A, Chow LQ, Koh WJ, Parvathaneni U
Ophthalmic Plast Reconstr Surg 2013 Jul-Aug;29(4):256-60. doi: 10.1097/IOP.0b013e318295f99b. PMID: 23839633
Long-term outcomes of neoadjuvant intra-arterial cytoreductive chemotherapy for lacrimal gland adenoid cystic carcinoma.
Tse DT, Kossler AL, Feuer WJ, Benedetto PW
Ophthalmology 2013 Jul;120(7):1313-23. Epub 2013 Apr 9 doi: 10.1016/j.ophtha.2013.01.027. PMID: 23582989Free PMC Article

Prognosis

Neoadjuvant Intra-Arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma: A Long-Term Follow-up Study of a Trimodal Strategy.
Tse DT, Benedetto PW, Tse BC, Feuer WJ
Am J Ophthalmol 2022 Aug;240:239-251. Epub 2022 Apr 2 doi: 10.1016/j.ajo.2022.03.027. PMID: 35381201Free PMC Article
Prognostic impact of Notch1 receptor and clinicopathological High-Risk Predictors in lacrimal gland adenoid cystic carcinoma.
Anjum S, Sen S, Pushker N, Bajaj MS, Kashyap S, Bakhshi S, Chosdol K, Meel R, Sharma MC
Acta Ophthalmol 2021 Dec;99(8):e1467-e1473. Epub 2021 Mar 6 doi: 10.1111/aos.14812. PMID: 33675181
Multimodal therapy in the management of lacrimal gland adenoid cystic carcinoma.
Yang J, Zhou C, Wang Y, Fan X, Jia R
BMC Ophthalmol 2019 Jun 8;19(1):125. doi: 10.1186/s12886-019-1110-5. PMID: 31176360Free PMC Article
Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma.
Sant DW, Tao W, Field MG, Pelaez D, Jin K, Capobianco A, Dubovy SR, Tse DT, Wang G
Invest Ophthalmol Vis Sci 2017 May 1;58(6):BIO240-BIO246. doi: 10.1167/iovs.16-21097. PMID: 28820917Free PMC Article
Neutron radiotherapy for adenoid cystic carcinoma of the lacrimal gland.
Gensheimer MF, Rainey D, Douglas JG, Liao JJ, Laramore GE, Jian-Amadi A, Chow LQ, Koh WJ, Parvathaneni U
Ophthalmic Plast Reconstr Surg 2013 Jul-Aug;29(4):256-60. doi: 10.1097/IOP.0b013e318295f99b. PMID: 23839633

Clinical prediction guides

AKT2 identified as a potential target of mir-29a-3p via microRNA profiling of patients with high proliferation lacrimal gland adenoid cystic carcinoma.
Zhao J, Liu X, Lin J, Jiang M, Xu F, Zhang C, Tang Q, Zhu L, Dong L, Lin T
Exp Eye Res 2022 Jun;219:109067. Epub 2022 Apr 7 doi: 10.1016/j.exer.2022.109067. PMID: 35398208
Vascular endothelial growth factor (VEGF) and hypoxia inducible factor-1 alpha (HIF-1ɑ) in lacrimal gland Adenoid cystic carcinoma: Correlation with clinical outcome.
Anjum S, Sen S, Chosdol K, Bakhshi S, Kashyap S, Pushker N, Bajaj MS, Meel R, Sharma MC
Ann Diagn Pathol 2022 Feb;56:151846. Epub 2021 Oct 29 doi: 10.1016/j.anndiagpath.2021.151846. PMID: 34749048
Prognostic impact of Notch1 receptor and clinicopathological High-Risk Predictors in lacrimal gland adenoid cystic carcinoma.
Anjum S, Sen S, Pushker N, Bajaj MS, Kashyap S, Bakhshi S, Chosdol K, Meel R, Sharma MC
Acta Ophthalmol 2021 Dec;99(8):e1467-e1473. Epub 2021 Mar 6 doi: 10.1111/aos.14812. PMID: 33675181
Histopathologic Observations of Eyes in Exenterated Orbits After Neoadjuvant Intra-Arterial Cytoreductive Chemotherapy for Adenoid Cystic Carcinoma of the Lacrimal Gland.
Liao SD, Erickson BP, Kapila N, Dubovy SR, Tse DT
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3):274-279. doi: 10.1097/IOP.0000000000001808. PMID: 32890114Free PMC Article
Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma.
Sant DW, Tao W, Field MG, Pelaez D, Jin K, Capobianco A, Dubovy SR, Tse DT, Wang G
Invest Ophthalmol Vis Sci 2017 May 1;58(6):BIO240-BIO246. doi: 10.1167/iovs.16-21097. PMID: 28820917Free PMC Article

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