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Low Grade Cervical Intraepithelial Neoplasia

MedGen UID:
87599
•Concept ID:
C0349458
•
Neoplastic Process
Synonyms: Cervical intraepithelial neoplasia grade 1; Cervical intraepithelial neoplasia grade I; CIN I - Cervical intraepithelial neoplasia 1; Low-Grade Cervix Intraepithelial Neoplasia; Low-Grade Cervix Uteri Intraepithelial Neoplasia; Low-Grade Intraepithelial Neoplasia of Cervix; Low-Grade Intraepithelial Neoplasia of Cervix Uteri; Low-Grade Intraepithelial Neoplasia of the Cervix; Low-Grade Intraepithelial Neoplasia of the Cervix Uteri; Low-Grade Intraepithelial Neoplasia of the Uterine Cervix; Low-Grade Intraepithelial Neoplasia of Uterine Cervix; Low-Grade Uterine Cervix Intraepithelial Neoplasia; Mild cervical dysplasia; Mild dysplasia of cervix
SNOMED CT: Cervical intraepithelial neoplasia grade 1 (285836003); Cervical intraepithelial neoplasia grade I (285836003); CIN I - Cervical intraepithelial neoplasia 1 (285836003); Mild cervical dysplasia (285836003); Mild dysplasia of cervix (285836003)

Definition

Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of mild dysplastic changes. [from NCI]

Professional guidelines

PubMed

Bovine Colostrum Treatment of Specific Cancer Types: Current Evidence and Future Opportunities.
Alsayed AR, Hasoun LZ, Khader HA, Basheti IA, Permana AD
Molecules 2022 Dec 7;27(24) doi: 10.3390/molecules27248641. PMID: 36557775Free PMC Article
Treatment of HPV Infection-Associated Low Grade Cervical Intraepithelial Neoplasia with 5-Aminolevulinic Acid-Mediated Photodynamic Therapy.
Li D, Zhang F, Shi L, Lin L, Cai Q, Xu Y
Photodiagnosis Photodyn Ther 2020 Dec;32:101974. Epub 2020 Aug 21 doi: 10.1016/j.pdpdt.2020.101974. PMID: 32835877
Controversies in the management of low-grade cervical intraepithelial neoplasia.
Richart RM, Wright TC Jr
Cancer 1993 Feb 15;71(4 Suppl):1413-21. doi: 10.1002/cncr.2820710406. PMID: 8381707

Recent clinical studies

Etiology

MicroRNA expression associated with low-grade cervical intraepithelial neoplasia outcomes.
Winters AN, Berry AK, Dewenter TA, Chowdhury NU, Wright KL, Cameron JE
J Cancer Res Clin Oncol 2023 Oct;149(13):11969-11978. Epub 2023 Jul 8 doi: 10.1007/s00432-023-05023-3. PMID: 37421453Free PMC Article
Is cryotherapy effective in all women with low-grade cervical intraepithelial neoplasia?
Nazari Z, Torabizadeh G, Khalilian A, Ghadami S, Karimi-Zarchi M, Allahqoli L, Gharacheh M, Salehiniya H, Alkatout I
Eur Rev Med Pharmacol Sci 2021 Jun;25(12):4211-4218. doi: 10.26355/eurrev_202106_26126. PMID: 34227088
Treatment of HPV Infection-Associated Low Grade Cervical Intraepithelial Neoplasia with 5-Aminolevulinic Acid-Mediated Photodynamic Therapy.
Li D, Zhang F, Shi L, Lin L, Cai Q, Xu Y
Photodiagnosis Photodyn Ther 2020 Dec;32:101974. Epub 2020 Aug 21 doi: 10.1016/j.pdpdt.2020.101974. PMID: 32835877
IGFBP-2 in cervical cancer development.
Kaur G, Balasubramaniam SD, Lee YJ
Exp Mol Pathol 2020 Apr;113:104362. Epub 2019 Dec 21 doi: 10.1016/j.yexmp.2019.104362. PMID: 31870856
Outcome of Persistent Low-Grade Cervical Intraepithelial Neoplasia Treated With Loop Electrosurgical Excision Procedure.
Spinillo A, Gardella B, Iacobone AD, Dominoni M, Cesari S, Alberizzi P
J Low Genit Tract Dis 2016 Oct;20(4):307-11. doi: 10.1097/LGT.0000000000000242. PMID: 27467826

Diagnosis

MicroRNA expression associated with low-grade cervical intraepithelial neoplasia outcomes.
Winters AN, Berry AK, Dewenter TA, Chowdhury NU, Wright KL, Cameron JE
J Cancer Res Clin Oncol 2023 Oct;149(13):11969-11978. Epub 2023 Jul 8 doi: 10.1007/s00432-023-05023-3. PMID: 37421453Free PMC Article
Is cryotherapy effective in all women with low-grade cervical intraepithelial neoplasia?
Nazari Z, Torabizadeh G, Khalilian A, Ghadami S, Karimi-Zarchi M, Allahqoli L, Gharacheh M, Salehiniya H, Alkatout I
Eur Rev Med Pharmacol Sci 2021 Jun;25(12):4211-4218. doi: 10.26355/eurrev_202106_26126. PMID: 34227088
Outcome of Persistent Low-Grade Cervical Intraepithelial Neoplasia Treated With Loop Electrosurgical Excision Procedure.
Spinillo A, Gardella B, Iacobone AD, Dominoni M, Cesari S, Alberizzi P
J Low Genit Tract Dis 2016 Oct;20(4):307-11. doi: 10.1097/LGT.0000000000000242. PMID: 27467826
Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia.
Luo Q, Lei B, Liu S, Chen Y, Sheng W, Lin P, Li W, Zhu H, Shen H
Int J Clin Exp Pathol 2014;7(11):8059-64. Epub 2014 Oct 15 PMID: 25550851Free PMC Article
Controversies in the management of low-grade cervical intraepithelial neoplasia.
Richart RM, Wright TC Jr
Cancer 1993 Feb 15;71(4 Suppl):1413-21. doi: 10.1002/cncr.2820710406. PMID: 8381707

Therapy

Treatment of HPV Infection-Associated Low Grade Cervical Intraepithelial Neoplasia with 5-Aminolevulinic Acid-Mediated Photodynamic Therapy.
Li D, Zhang F, Shi L, Lin L, Cai Q, Xu Y
Photodiagnosis Photodyn Ther 2020 Dec;32:101974. Epub 2020 Aug 21 doi: 10.1016/j.pdpdt.2020.101974. PMID: 32835877
Efficacy and safety of hexaminolevulinate photodynamic therapy in patients with low-grade cervical intraepithelial neoplasia.
Hillemanns P, Petry KU, Soergel P, Collinet P, Ardaens K, Gallwas J, Luyten A, Dannecker C
Lasers Surg Med 2014 Aug;46(6):456-61. Epub 2014 May 6 doi: 10.1002/lsm.22255. PMID: 24799181
Results of a phase II randomized, double-blind, placebo-controlled trial of Polyphenon E in women with persistent high-risk HPV infection and low-grade cervical intraepithelial neoplasia.
Garcia FA, Cornelison T, Nuño T, Greenspan DL, Byron JW, Hsu CH, Alberts DS, Chow HH
Gynecol Oncol 2014 Feb;132(2):377-82. Epub 2014 Jan 2 doi: 10.1016/j.ygyno.2013.12.034. PMID: 24388920Free PMC Article
Expectant management versus immediate treatment for low-grade cervical intraepithelial neoplasia : a randomized trial in Canada and Brazil.
Elit L, Levine MN, Julian JA, Sellors JW, Lytwyn A, Chong S, Mahony JB, Gu C, Finch T, Zeferino LC
Cancer 2011 Apr 1;117(7):1438-45. Epub 2010 Nov 8 doi: 10.1002/cncr.25635. PMID: 21425144
Cellular immunodeficiency enhances the progression of human papillomavirus-associated cervical lesions.
Petry KU, Scheffel D, Bode U, Gabrysiak T, Köchel H, Kupsch E, Glaubitz M, Niesert S, Kühnle H, Schedel I
Int J Cancer 1994 Jun 15;57(6):836-40. doi: 10.1002/ijc.2910570612. PMID: 7911455

Prognosis

MicroRNA expression associated with low-grade cervical intraepithelial neoplasia outcomes.
Winters AN, Berry AK, Dewenter TA, Chowdhury NU, Wright KL, Cameron JE
J Cancer Res Clin Oncol 2023 Oct;149(13):11969-11978. Epub 2023 Jul 8 doi: 10.1007/s00432-023-05023-3. PMID: 37421453Free PMC Article
Endocervicoscopy and Biopsy to Detect Cervical Intraepithelial Squamous Neoplasia in Nonvisible Squamocolumnar Junction With Unsatisfactory Colposcopy: A Pilot Study.
Rahimi S, Marani C, Gardner F, Yeoh CC, Akaev I, Votano S
Technol Cancer Res Treat 2018 Jan 1;17:1533034617753811. doi: 10.1177/1533034617753811. PMID: 29375019Free PMC Article
p16INK4a, Cytokeratin 7, and Ki-67 as Potential Markers for Low-Grade Cervical Intraepithelial Neoplasia Progression.
da Costa LBE, Triglia RM, Andrade LALA
J Low Genit Tract Dis 2017 Jul;21(3):171-176. doi: 10.1097/LGT.0000000000000310. PMID: 28403025
Outcome of Persistent Low-Grade Cervical Intraepithelial Neoplasia Treated With Loop Electrosurgical Excision Procedure.
Spinillo A, Gardella B, Iacobone AD, Dominoni M, Cesari S, Alberizzi P
J Low Genit Tract Dis 2016 Oct;20(4):307-11. doi: 10.1097/LGT.0000000000000242. PMID: 27467826
Human papillomavirus infection and cervical intraepithelial neoplasia: histopathology and DNA content.
Fujii T, Crum CP, Winkler B, Fu YS, Richart RM
Obstet Gynecol 1984 Jan;63(1):99-104. PMID: 6318171

Clinical prediction guides

MicroRNA expression associated with low-grade cervical intraepithelial neoplasia outcomes.
Winters AN, Berry AK, Dewenter TA, Chowdhury NU, Wright KL, Cameron JE
J Cancer Res Clin Oncol 2023 Oct;149(13):11969-11978. Epub 2023 Jul 8 doi: 10.1007/s00432-023-05023-3. PMID: 37421453Free PMC Article
Endocervicoscopy and Biopsy to Detect Cervical Intraepithelial Squamous Neoplasia in Nonvisible Squamocolumnar Junction With Unsatisfactory Colposcopy: A Pilot Study.
Rahimi S, Marani C, Gardner F, Yeoh CC, Akaev I, Votano S
Technol Cancer Res Treat 2018 Jan 1;17:1533034617753811. doi: 10.1177/1533034617753811. PMID: 29375019Free PMC Article
p16INK4a, Cytokeratin 7, and Ki-67 as Potential Markers for Low-Grade Cervical Intraepithelial Neoplasia Progression.
da Costa LBE, Triglia RM, Andrade LALA
J Low Genit Tract Dis 2017 Jul;21(3):171-176. doi: 10.1097/LGT.0000000000000310. PMID: 28403025
Follow-up study of patients with cervical intraepithelial neoplasia grade 1 overexpressing p16Ink4a.
Cortecchia S, Galanti G, Sgadari C, Costa S, De Lillo M, Caprara L, Barillari G, Monini P, Nannini R, Ensoli B, Bucchi L
Int J Gynecol Cancer 2013 Nov;23(9):1663-9. doi: 10.1097/IGC.0b013e3182a80b14. PMID: 24172101
Human papillomavirus infection and cervical intraepithelial neoplasia: histopathology and DNA content.
Fujii T, Crum CP, Winkler B, Fu YS, Richart RM
Obstet Gynecol 1984 Jan;63(1):99-104. PMID: 6318171

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