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Anal margin carcinoma

MedGen UID:
87604
•Concept ID:
C0349534
•
Neoplastic Process
Synonyms: anal margin cancer; Anal Margin Carcinoma; anal margin carcinoma; Carcinoma of anal margin; Carcinoma of Anal Margin; carcinoma of anal margin; carcinoma of perianal skin; Carcinoma of the Anal Margin; carcinoma of the anal margin; Perianal Skin Carcinoma; perianal skin carcinoma
SNOMED CT: Carcinoma of anal margin (255084004)
 
Monarch Initiative: MONDO:0002941

Definition

A carcinoma arising in the anal margin or perianal skin (below the anal verge and involving the perianal hair-bearing skin). It includes basal cell and squamous cell carcinoma. Anal margin carcinoma is staged as a skin carcinoma, separately from anal canal carcinoma. [from NCI]

Professional guidelines

PubMed

The management of anal carcinoma.
Madden MV, Elliot MS, Botha JB, Louw JH
Br J Surg 1981 Apr;68(4):287-9. doi: 10.1002/bjs.1800680420. PMID: 7225745

Recent clinical studies

Etiology

Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany.
Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Swoboda J, Stücker M, Schmitt M, Pfister H, Wieland U; German Competence Network HIV/AIDS
Br J Dermatol 2010 Jun;162(6):1269-77. Epub 2010 Feb 22 doi: 10.1111/j.1365-2133.2010.09712.x. PMID: 20184584
Patterns of failure and outcome in patients with carcinoma of the anal margin.
Khanfir K, Ozsahin M, Bieri S, Cavuto C, Mirimanoff RO, Zouhair A
Ann Surg Oncol 2008 Apr;15(4):1092-8. Epub 2008 Jan 30 doi: 10.1245/s10434-007-9794-9. PMID: 18231838
Squamous cell carcinoma of the anus at one hospital from 1948 to 1984.
Pintor MP, Northover JM, Nicholls RJ
Br J Surg 1989 Aug;76(8):806-10. doi: 10.1002/bjs.1800760814. PMID: 2765832
The management of anal carcinoma.
Madden MV, Elliot MS, Botha JB, Louw JH
Br J Surg 1981 Apr;68(4):287-9. doi: 10.1002/bjs.1800680420. PMID: 7225745

Diagnosis

Squamous cell carcinoma of the anal margin with pruritus ani of long duration.
Handa Y, Watanabe O, Adachi A, Yamanaka N
Dermatol Surg 2003 Jan;29(1):108-10. doi: 10.1046/j.1524-4725.2003.29003.x. PMID: 12534524

Therapy

Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany.
Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Swoboda J, Stücker M, Schmitt M, Pfister H, Wieland U; German Competence Network HIV/AIDS
Br J Dermatol 2010 Jun;162(6):1269-77. Epub 2010 Feb 22 doi: 10.1111/j.1365-2133.2010.09712.x. PMID: 20184584
Anal margin carcinoma: 21 cases treated at the Institut Curie by exclusive conservative radiotherapy.
Cutuli B, Fenton J, Labib A, Bataini JP, Mathieu G
Radiother Oncol 1988 Jan;11(1):1-6. doi: 10.1016/0167-8140(88)90040-0. PMID: 3344351
Squamous-cell carcinoma of the anal canal.
Gordon PH
Surg Clin North Am 1988 Dec;68(6):1391-9. doi: 10.1016/s0039-6109(16)44694-3. PMID: 3057665

Prognosis

Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany.
Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Swoboda J, Stücker M, Schmitt M, Pfister H, Wieland U; German Competence Network HIV/AIDS
Br J Dermatol 2010 Jun;162(6):1269-77. Epub 2010 Feb 22 doi: 10.1111/j.1365-2133.2010.09712.x. PMID: 20184584
Anal margin carcinoma: 21 cases treated at the Institut Curie by exclusive conservative radiotherapy.
Cutuli B, Fenton J, Labib A, Bataini JP, Mathieu G
Radiother Oncol 1988 Jan;11(1):1-6. doi: 10.1016/0167-8140(88)90040-0. PMID: 3344351
Squamous-cell carcinoma of the anal canal.
Gordon PH
Surg Clin North Am 1988 Dec;68(6):1391-9. doi: 10.1016/s0039-6109(16)44694-3. PMID: 3057665

Clinical prediction guides

Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany.
Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Swoboda J, Stücker M, Schmitt M, Pfister H, Wieland U; German Competence Network HIV/AIDS
Br J Dermatol 2010 Jun;162(6):1269-77. Epub 2010 Feb 22 doi: 10.1111/j.1365-2133.2010.09712.x. PMID: 20184584
Patterns of failure and outcome in patients with carcinoma of the anal margin.
Khanfir K, Ozsahin M, Bieri S, Cavuto C, Mirimanoff RO, Zouhair A
Ann Surg Oncol 2008 Apr;15(4):1092-8. Epub 2008 Jan 30 doi: 10.1245/s10434-007-9794-9. PMID: 18231838
Squamous cell carcinoma of the anal margin with pruritus ani of long duration.
Handa Y, Watanabe O, Adachi A, Yamanaka N
Dermatol Surg 2003 Jan;29(1):108-10. doi: 10.1046/j.1524-4725.2003.29003.x. PMID: 12534524

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