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Neoplasm of femur

MedGen UID:: 8809
•Concept ID:: C0015807
•: Neoplastic Process

Synonyms:	Femoral Neoplasm; Femoral Neoplasms; Neoplasm, Femoral; Neoplasms, Femoral
SNOMED CT:	Neoplasm of femur (126583006)

Monarch Initiative:	MONDO:0021579

Definition

A neoplasm (disease) that involves the femur. [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeoplasm of femur

Pathological process
- Disease
  - Disorder by Site
    - Connective and Soft Tissue Disorder
      - Connective tissue disorder
        Bone Neoplasm
        Neoplasm of femur

Professional guidelines

PubMed

Imaging Features and Management of Stress, Atypical, and Pathologic Fractures.

Marshall RA, Mandell JC, Weaver MJ, Ferrone M, Sodickson A, Khurana B
Radiographics 2018 Nov-Dec;38(7):2173-2192. doi: 10.1148/rg.2018180073. PMID: 30422769

Bone Cancer: Diagnosis and Treatment Principles.

Ferguson JL, Turner SP
Am Fam Physician 2018 Aug 15;98(4):205-213. PMID: 30215968

Management of Vulvar Cancer.

Rajaram S, Gupta B
Rev Recent Clin Trials 2015;10(4):282-8. doi: 10.2174/1574887110666150923112723. PMID: 26411953

See all (331)

Recent clinical studies

Etiology

Risk of complications and implant survival of surgical treatment of proximal femoral metastasis: a meta-analysis.

Solou K, Cosentino M, Atherley O'Meally A, Aso A, Aiba H, Donati DM, Bordini B, Errani C
Eur J Orthop Surg Traumatol 2024 May;34(4):1779-1794. Epub 2024 Apr 5 doi: 10.1007/s00590-024-03930-w. PMID: 38578441

The Metastatic Early Prognostic (MEP) score.

Downie S, Lai FY, Joss J, Adamson D, Jariwala AC
Bone Joint J 2020 Jan;102-B(1):72-81. doi: 10.1302/0301-620X.102B1.BJJ-2019-0794.R1. PMID: 31888363

Current orthopaedic management of bony metastases in the proximal third of the femur.

Jonas SC, Mehendale SM, Bick SM, Baker RP
Hip Int 2017 Feb 21;27(1):1-7. Epub 2017 Feb 8 doi: 10.5301/hipint.5000497. PMID: 28218377

Multicentric osteosarcoma.

Hameed S, Vijayan S, Naik M, Rao S
Singapore Med J 2012 Oct;53(10):e214-7. PMID: 23112033

Dedifferentiated parosteal osteosarcoma.

Wold LE, Unni KK, Beabout JW, Sim FH, Dahlin DC
J Bone Joint Surg Am 1984 Jan;66(1):53-9. PMID: 6581170

See all (2802)

Diagnosis

The surgical management and treatment of metastatic lesions in the proximal femur: A mini review.

Feng H, Wang J, Xu J, Chen W, Zhang Y
Medicine (Baltimore) 2016 Jul;95(28):e3892. doi: 10.1097/MD.0000000000003892. PMID: 27428183 Free PMC Article

Multicentric osteosarcoma.

Hameed S, Vijayan S, Naik M, Rao S
Singapore Med J 2012 Oct;53(10):e214-7. PMID: 23112033

Metastatic lesions of the proximal femur.

Doung YC, Kenan S, Rapp T
Bull NYU Hosp Jt Dis 2011;69(1):81-6. PMID: 21332443

Intracortical osteosarcoma.

Griffith JF, Kumta SM, Chow LT, Leung PC, Metreweli C
Skeletal Radiol 1998 Apr;27(4):228-32. doi: 10.1007/s002560050372. PMID: 9592909

Juxtacortical chondrosarcoma.

Schajowicz F
J Bone Joint Surg Br 1977 Nov;59-B(4):473-80. doi: 10.1302/0301-620X.59B4.270475. PMID: 270475

See all (2673)

Therapy

Risk of complications and implant survival of surgical treatment of proximal femoral metastasis: a meta-analysis.

Clinical evaluations of diaphysis malignant tumors of femur and tibia treated with microwave ablation in situ.

Yu Z, Dong C, Zhang M, Gao T, Ding R, Yang Y, Fan Q
J Orthop Surg Res 2020 Apr 9;15(1):139. doi: 10.1186/s13018-020-01662-1. PMID: 32272956 Free PMC Article

Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone.

Lipplaa A, Dijkstra S, Gelderblom H
Curr Opin Oncol 2019 Jul;31(4):329-335. doi: 10.1097/CCO.0000000000000529. PMID: 30844887 Free PMC Article

Management of extremity arterial pseudoaneurysms associated with osteochondromas.

Raherinantenaina F, Rakoto-Ratsimba HN, Rajaonanahary TM
Vascular 2016 Dec;24(6):628-637. Epub 2016 Mar 3 doi: 10.1177/1708538116634532. PMID: 26944530

Giant cell tumor of bone.

Yasko AW
Curr Oncol Rep 2002 Nov;4(6):520-6. doi: 10.1007/s11912-002-0067-2. PMID: 12354366

See all (1992)

Prognosis

Treatment for long bone metastases based on a systematic literature review.

Errani C, Mavrogenis AF, Cevolani L, Spinelli S, Piccioli A, Maccauro G, Baldini N, Donati D
Eur J Orthop Surg Traumatol 2017 Feb;27(2):205-211. Epub 2016 Sep 20 doi: 10.1007/s00590-016-1857-9. PMID: 27650452

Multicentric osteosarcoma.

Hameed S, Vijayan S, Naik M, Rao S
Singapore Med J 2012 Oct;53(10):e214-7. PMID: 23112033

Dedifferentiated parosteal osteosarcoma.

Wold LE, Unni KK, Beabout JW, Sim FH, Dahlin DC
J Bone Joint Surg Am 1984 Jan;66(1):53-9. PMID: 6581170

Juxtacortical chondrosarcoma.

Schajowicz F
J Bone Joint Surg Br 1977 Nov;59-B(4):473-80. doi: 10.1302/0301-620X.59B4.270475. PMID: 270475

Malignant osteoblastoma.

Schajowicz F, Lemos C
J Bone Joint Surg Br 1976 May;58(2):202-11. doi: 10.1302/0301-620X.58B2.932083. PMID: 932083

See all (1875)

Clinical prediction guides

Clinical Application of Artificial Intelligence: Auto-Discerning the Effectiveness of Lidocaine Concentration Levels in Osteosarcoma Femoral Tumor Segment Resection.

Ni S, Li X, Yi X
J Healthc Eng 2022;2022:7069348. Epub 2022 Mar 28 doi: 10.1155/2022/7069348. PMID: 35388316 Free PMC Article

Role of PRPS2 as a prognostic and therapeutic target in osteosarcoma.

Luo Y, Yuan J, Huang J, Yang T, Zhou J, Tang J, Liu M, Chen J, Chen C, Huang W, Zhang H
J Clin Pathol 2021 May;74(5):321-326. Epub 2021 Feb 15 doi: 10.1136/jclinpath-2020-206505. PMID: 33589531

The Metastatic Early Prognostic (MEP) score.

Downie S, Lai FY, Joss J, Adamson D, Jariwala AC
Bone Joint J 2020 Jan;102-B(1):72-81. doi: 10.1302/0301-620X.102B1.BJJ-2019-0794.R1. PMID: 31888363

Management of extremity arterial pseudoaneurysms associated with osteochondromas.

Raherinantenaina F, Rakoto-Ratsimba HN, Rajaonanahary TM
Vascular 2016 Dec;24(6):628-637. Epub 2016 Mar 3 doi: 10.1177/1708538116634532. PMID: 26944530

Giant cell tumor of bone.

Yasko AW
Curr Oncol Rep 2002 Nov;4(6):520-6. doi: 10.1007/s11912-002-0067-2. PMID: 12354366

See all (1586)

Recent systematic reviews

Imaging of non-neurogenic peripheral nerve malignancy-a case series and systematic review.

Luna R, Fayad LM, Rodriguez FJ, Ahlawat S
Skeletal Radiol 2021 Jan;50(1):201-215. Epub 2020 Jul 23 doi: 10.1007/s00256-020-03556-z. PMID: 32699955

Pathologic fractures of the distal femur: Current concepts and treatment options.

Willeumier JJ, van der Wal CWPG, Schoones JW, van der Wal RJ, Dijkstra PDS
J Surg Oncol 2018 Nov;118(6):883-890. Epub 2018 Oct 17 doi: 10.1002/jso.25218. PMID: 30328621

Vulvar cancer: initial management and systematic review of literature on currently applied treatment approaches.

Sznurkowski JJ
Eur J Cancer Care (Engl) 2016 Jul;25(4):638-46. Epub 2016 Feb 16 doi: 10.1111/ecc.12455. PMID: 26880231

Feasibility and Safety of Video Endoscopic Inguinal Lymphadenectomy in Vulvar Cancer: A Systematic Review.

Liu CE, Lu Y, Yao DS
PLoS One 2015;10(10):e0140873. Epub 2015 Oct 23 doi: 10.1371/journal.pone.0140873. PMID: 26496391 Free PMC Article

A systematic review of selected musculoskeletal late effects in survivors of childhood cancer.

Gawade PL, Hudson MM, Kaste SC, Neglia JP, Wasilewski-Masker K, Constine LS, Robison LL, Ness KK
Curr Pediatr Rev 2014;10(4):249-62. doi: 10.2174/1573400510666141114223827. PMID: 25403639 Free PMC Article

See all (55)

MedGen

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Neoplasm of femur

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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