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Secondary Peripheral Chondrosarcoma

MedGen UID:
882747
•Concept ID:
C4054043
•
Neoplastic Process

Definition

A chondrosarcoma arising within the cartilaginous cap of a pre-existing osteochondroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary Peripheral Chondrosarcoma

Professional guidelines

PubMed

Management of the Hand Tumors.
Datta NK, Das KP, Aish PK, Datta M, Banik SK, Sen SK, Chowdhury RM
Mymensingh Med J 2023 Jan;32(1):135-143. PMID: 36594313
Pelvic chondrosarcomas: surgical treatment options.
Deloin X, Dumaine V, Biau D, Karoubi M, Babinet A, Tomeno B, Anract P
Orthop Traumatol Surg Res 2009 Oct;95(6):393-401. Epub 2009 Oct 3 doi: 10.1016/j.otsr.2009.05.004. PMID: 19801212

Recent clinical studies

Etiology

Secondary peripheral chondrosarcoma in multiple osteochondromas: a retrospective single-institution case series.
Gnoli M, Gambarotti M, Righi A, Staals EL, Evangelista A, Tremosini M, Brizola E, Mordenti M, Boarini M, Locatelli M, Pedrini E, Sangiorgi L
Orphanet J Rare Dis 2024 Feb 13;19(1):63. doi: 10.1186/s13023-023-03006-8. PMID: 38351015Free PMC Article
Secondary peripheral chondrosarcoma arising in solitary osteochondroma: variables influencing prognosis and survival.
Righi A, Pacheco M, Cocchi S, Asioli S, Gambarotti M, Donati DM, Evangelista A, Gnoli M, Locatelli M, Mordenti M, Boarini M, Brizola E, Pedrini E, Sangiorgi L
Orphanet J Rare Dis 2022 Feb 22;17(1):74. doi: 10.1186/s13023-022-02210-2. PMID: 35193636Free PMC Article
Intraosseous atypical chondroid tumor or chondrosarcoma grade 1 in patients with multiple osteochondromas.
Goud AL, Wuyts W, Bessems J, Bramer J, van der Woude HJ, Ham J
J Bone Joint Surg Am 2015 Jan 7;97(1):24-31. doi: 10.2106/JBJS.N.00121. PMID: 25568391
Peripheral chondrosarcoma progression is associated with increased type X collagen and vascularisation.
de Andrea CE, Wiweger MI, Bovée JV, Romeo S, Hogendoorn PC
Virchows Arch 2012 Jan;460(1):95-102. Epub 2011 Nov 25 doi: 10.1007/s00428-011-1168-9. PMID: 22116208Free PMC Article

Diagnosis

Secondary peripheral chondrosarcoma in multiple osteochondromas: a retrospective single-institution case series.
Gnoli M, Gambarotti M, Righi A, Staals EL, Evangelista A, Tremosini M, Brizola E, Mordenti M, Boarini M, Locatelli M, Pedrini E, Sangiorgi L
Orphanet J Rare Dis 2024 Feb 13;19(1):63. doi: 10.1186/s13023-023-03006-8. PMID: 38351015Free PMC Article
Secondary peripheral chondrosarcoma arising in solitary osteochondroma: variables influencing prognosis and survival.
Righi A, Pacheco M, Cocchi S, Asioli S, Gambarotti M, Donati DM, Evangelista A, Gnoli M, Locatelli M, Mordenti M, Boarini M, Brizola E, Pedrini E, Sangiorgi L
Orphanet J Rare Dis 2022 Feb 22;17(1):74. doi: 10.1186/s13023-022-02210-2. PMID: 35193636Free PMC Article
An unusual diagnosis for an usual test.
Trombetta A, Migliarino V, Faletra F, Barbi E, Tornese G
Ital J Pediatr 2020 Jun 10;46(1):81. doi: 10.1186/s13052-020-00846-z. PMID: 32522262Free PMC Article
Multiple osteochondromas.
Bovée JV
Orphanet J Rare Dis 2008 Feb 13;3:3. doi: 10.1186/1750-1172-3-3. PMID: 18271966Free PMC Article
Diagnosis and prognosis of chondrosarcoma of bone.
Rozeman LB, Hogendoorn PC, Bovée JV
Expert Rev Mol Diagn 2002 Sep;2(5):461-72. doi: 10.1586/14737159.2.5.461. PMID: 12271817

Therapy

Decreased EXT expression and intracellular accumulation of heparan sulphate proteoglycan in osteochondromas and peripheral chondrosarcomas.
Hameetman L, David G, Yavas A, White SJ, Taminiau AH, Cleton-Jansen AM, Hogendoorn PC, Bovée JV
J Pathol 2007 Mar;211(4):399-409. doi: 10.1002/path.2127. PMID: 17226760

Prognosis

Secondary peripheral chondrosarcoma in multiple osteochondromas: a retrospective single-institution case series.
Gnoli M, Gambarotti M, Righi A, Staals EL, Evangelista A, Tremosini M, Brizola E, Mordenti M, Boarini M, Locatelli M, Pedrini E, Sangiorgi L
Orphanet J Rare Dis 2024 Feb 13;19(1):63. doi: 10.1186/s13023-023-03006-8. PMID: 38351015Free PMC Article
Secondary peripheral chondrosarcoma arising in solitary osteochondroma: variables influencing prognosis and survival.
Righi A, Pacheco M, Cocchi S, Asioli S, Gambarotti M, Donati DM, Evangelista A, Gnoli M, Locatelli M, Mordenti M, Boarini M, Brizola E, Pedrini E, Sangiorgi L
Orphanet J Rare Dis 2022 Feb 22;17(1):74. doi: 10.1186/s13023-022-02210-2. PMID: 35193636Free PMC Article
Multiple osteochondromas.
Bovée JV
Orphanet J Rare Dis 2008 Feb 13;3:3. doi: 10.1186/1750-1172-3-3. PMID: 18271966Free PMC Article
The use of Bcl-2 and PTHLH immunohistochemistry in the diagnosis of peripheral chondrosarcoma in a clinicopathological setting.
Hameetman L, Kok P, Eilers PH, Cleton-Jansen AM, Hogendoorn PC, Bovée JV
Virchows Arch 2005 Apr;446(4):430-7. Epub 2005 Mar 3 doi: 10.1007/s00428-005-1208-4. PMID: 15744499
Diagnosis and prognosis of chondrosarcoma of bone.
Rozeman LB, Hogendoorn PC, Bovée JV
Expert Rev Mol Diagn 2002 Sep;2(5):461-72. doi: 10.1586/14737159.2.5.461. PMID: 12271817

Clinical prediction guides

Interobserver reliability in the histopathological diagnosis of cartilaginous tumors in patients with multiple osteochondromas.
de Andrea CE, Kroon HM, Wolterbeek R, Romeo S, Rosenberg AE, De Young BR, Liegl B, Inwards CY, Hauben E, McCarthy EF, Idoate M, Athanasou NA, Jones KB, Hogendoorn PC, Bovée JV
Mod Pathol 2012 Sep;25(9):1275-83. Epub 2012 May 4 doi: 10.1038/modpathol.2012.78. PMID: 22555180Free PMC Article
Peripheral chondrosarcoma progression is associated with increased type X collagen and vascularisation.
de Andrea CE, Wiweger MI, Bovée JV, Romeo S, Hogendoorn PC
Virchows Arch 2012 Jan;460(1):95-102. Epub 2011 Nov 25 doi: 10.1007/s00428-011-1168-9. PMID: 22116208Free PMC Article
The use of Bcl-2 and PTHLH immunohistochemistry in the diagnosis of peripheral chondrosarcoma in a clinicopathological setting.
Hameetman L, Kok P, Eilers PH, Cleton-Jansen AM, Hogendoorn PC, Bovée JV
Virchows Arch 2005 Apr;446(4):430-7. Epub 2005 Mar 3 doi: 10.1007/s00428-005-1208-4. PMID: 15744499
Diagnosis and prognosis of chondrosarcoma of bone.
Rozeman LB, Hogendoorn PC, Bovée JV
Expert Rev Mol Diagn 2002 Sep;2(5):461-72. doi: 10.1586/14737159.2.5.461. PMID: 12271817

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