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Fetal-maternal hemorrhage

MedGen UID:
8829
•Concept ID:
C0015959
•
Pathologic Function
Synonyms: Fetomaternal Hemorrhage; Fetomaternal Hemorrhages; Fetomaternal Transfusion; Fetomaternal Transfusions; Hemorrhage, Fetomaternal; Hemorrhages, Fetomaternal; Transfusion, Fetomaternal; Transfusions, Fetomaternal
SNOMED CT: Fetal-maternal hemorrhage (71028008); Leakage of fetal blood into maternal circulation (71028008); Transplacental fetomaternal hemorrhage (71028008); Fetomaternal transfusion (71028008); Fetal hemorrhage into mother's circulation (71028008); Fetomaternal hemorrhage (71028008); Fetal maternal hemorrhage (71028008)

Definition

Loss of fetal blood into the maternal circulation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal-maternal hemorrhage

Professional guidelines

PubMed

Guidelines for the Management of a Pregnant Trauma Patient.
Jain V, Chari R, Maslovitz S, Farine D; Maternal Fetal Medicine Committee, Bujold E, Gagnon R, Basso M, Bos H, Brown R, Cooper S, Gouin K, McLeod NL, Menticoglou S, Mundle W, Pylypjuk C, Roggensack A, Sanderson F
J Obstet Gynaecol Can 2015 Jun;37(6):553-74. doi: 10.1016/s1701-2163(15)30232-2. PMID: 26334607
Clinical utility of flow cytometry in the study of erythropoiesis and nonclonal red cell disorders.
Chesney A, Good D, Reis M
Methods Cell Biol 2011;103:311-32. doi: 10.1016/B978-0-12-385493-3.00013-9. PMID: 21722809
Prevention and management of RhD isoimmunization.
Harkness UF, Spinnato JA
Clin Perinatol 2004 Dec;31(4):721-42, vi. doi: 10.1016/j.clp.2004.06.005. PMID: 15519425

Recent clinical studies

Etiology

Fetal Growth and Stillbirth.
Page JM, Blue NR, Silver RM
Obstet Gynecol Clin North Am 2021 Jun;48(2):297-310. doi: 10.1016/j.ogc.2021.03.001. PMID: 33972067
Fetal-Maternal Hemorrhage in First-Trimester Intrauterine Hematoma.
Narciso TARM, Hoshida MS, Costa PR, Niquirilo A, Biancolin SE, Lin LH, Francisco RPV, Brizot ML
Fetal Diagn Ther 2021;48(3):227-234. Epub 2021 Mar 11 doi: 10.1159/000513747. PMID: 33706316
Perinatal death investigations: What is current practice?
Nijkamp JW, Sebire NJ, Bouman K, Korteweg FJ, Erwich JJHM, Gordijn SJ
Semin Fetal Neonatal Med 2017 Jun;22(3):167-175. Epub 2017 Mar 18 doi: 10.1016/j.siny.2017.02.005. PMID: 28325580Free PMC Article
Fetal death.
Silver RM
Obstet Gynecol 2007 Jan;109(1):153-67. doi: 10.1097/01.AOG.0000248537.89739.96. PMID: 17197601
Transplacental fetal-maternal hemorrhage.
Sullivan JF, Jennings ER
Am J Clin Pathol 1966 Jul;46(1):36-42. doi: 10.1093/ajcp/46.1.36. PMID: 5949761

Diagnosis

Approach to red blood cell antibody testing during pregnancy: Answers to commonly asked questions.
Minuk L, Clarke G, Lieberman L
Can Fam Physician 2020 Jul;66(7):491-498. PMID: 32675093Free PMC Article
Evaluation of stillbirth.
Page JM, Silver RM
Curr Opin Obstet Gynecol 2018 Apr;30(2):130-135. doi: 10.1097/GCO.0000000000000441. PMID: 29489503
Perinatal death investigations: What is current practice?
Nijkamp JW, Sebire NJ, Bouman K, Korteweg FJ, Erwich JJHM, Gordijn SJ
Semin Fetal Neonatal Med 2017 Jun;22(3):167-175. Epub 2017 Mar 18 doi: 10.1016/j.siny.2017.02.005. PMID: 28325580Free PMC Article
A system for counting fetal and maternal red blood cells.
Ge J, Gong Z, Chen J, Liu J, Nguyen J, Yang Z, Wang C, Sun Y
IEEE Trans Biomed Eng 2014 Dec;61(12):2823-9. Epub 2014 May 29 doi: 10.1109/TBME.2014.2327198. PMID: 24879644
Prevention and management of RhD isoimmunization.
Harkness UF, Spinnato JA
Clin Perinatol 2004 Dec;31(4):721-42, vi. doi: 10.1016/j.clp.2004.06.005. PMID: 15519425

Therapy

Approach to red blood cell antibody testing during pregnancy: Answers to commonly asked questions.
Minuk L, Clarke G, Lieberman L
Can Fam Physician 2020 Jul;66(7):491-498. PMID: 32675093Free PMC Article
Case Report of Anemia Following Fetal-Maternal Hemorrhage.
Coe KL
Adv Neonatal Care 2019 Jun;19(3):198-204. doi: 10.1097/ANC.0000000000000618. PMID: 30969944
Fetal-Maternal Hemorrhage Detected by Sudden Disappearance of Rh Immune Globulin-Related Anti-D.
King JR, Zeger GD, Plaza N, Lee RH, Shulman IA
Obstet Gynecol 2015 Dec;126(6):1301-1302. doi: 10.1097/AOG.0000000000001013. PMID: 26375716
Fetal-maternal hemorrhage detection in Ontario.
Lafferty JD, Raby A, Crawford L, Linkins LA, Richardson H, Crowther M
Am J Clin Pathol 2003 Jan;119(1):72-7. doi: 10.1309/3U97-V732-7JBD-PAYN. PMID: 12520700
Fetal-maternal hemorrhage after amniocentesis: incidence, degree and ramifications.
Goldstein AI, Pezzlo F
Int J Gynaecol Obstet 1978-1979;16(3):187-9. doi: 10.1002/j.1879-3479.1978.tb00425.x. PMID: 33076

Prognosis

Diagnostic Tests for Evaluation of Stillbirth: Results From the Stillbirth Collaborative Research Network.
Page JM, Christiansen-Lindquist L, Thorsten V, Parker CB, Reddy UM, Dudley DJ, Saade GR, Coustan D, Rowland Hogue CJ, Conway D, Bukowski R, Pinar H, Heuser CC, Gibbins KJ, Goldenberg RL, Silver RM
Obstet Gynecol 2017 Apr;129(4):699-706. doi: 10.1097/AOG.0000000000001937. PMID: 28333795
Perinatal death investigations: What is current practice?
Nijkamp JW, Sebire NJ, Bouman K, Korteweg FJ, Erwich JJHM, Gordijn SJ
Semin Fetal Neonatal Med 2017 Jun;22(3):167-175. Epub 2017 Mar 18 doi: 10.1016/j.siny.2017.02.005. PMID: 28325580Free PMC Article
Heterogeneity of F cells in β-thalassemia.
Prus E, Fibach E
Transfusion 2013 Mar;53(3):499-504. Epub 2012 Jun 28 doi: 10.1111/j.1537-2995.2012.03769.x. PMID: 22738617
Fetal death.
Silver RM
Obstet Gynecol 2007 Jan;109(1):153-67. doi: 10.1097/01.AOG.0000248537.89739.96. PMID: 17197601
Clinical high-risk designation does not predict excess fetal-maternal hemorrhage.
Ness PM, Baldwin ML, Niebyl JR
Am J Obstet Gynecol 1987 Jan;156(1):154-8. doi: 10.1016/0002-9378(87)90228-6. PMID: 3026183

Clinical prediction guides

Heterogeneity of F cells in β-thalassemia.
Prus E, Fibach E
Transfusion 2013 Mar;53(3):499-504. Epub 2012 Jun 28 doi: 10.1111/j.1537-2995.2012.03769.x. PMID: 22738617
Transplacental hemorrhage associated with placental neoplasms.
Santamaria M, Benirschke K, Carpenter PM, Baldwin VJ, Pritchard JA
Pediatr Pathol 1987;7(5-6):601-15. doi: 10.3109/15513818709161424. PMID: 3449817
Clinical high-risk designation does not predict excess fetal-maternal hemorrhage.
Ness PM, Baldwin ML, Niebyl JR
Am J Obstet Gynecol 1987 Jan;156(1):154-8. doi: 10.1016/0002-9378(87)90228-6. PMID: 3026183
Life-threatening fetal anemia secondary to fetal-maternal hemorrhage. A case report.
Prout RE
J Reprod Med 1983 Sep;28(9):604-6. PMID: 6631847
The assessment of fetal-maternal hemorrhage by an enzyme-linked antiglobulin test for Rh immune globulin recipients.
Ness PM
Am J Obstet Gynecol 1982 Aug 1;143(7):788-92. doi: 10.1016/0002-9378(82)90011-4. PMID: 6179419

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