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Lepidic Adenocarcinoma

MedGen UID:: 883345
•Concept ID:: C4049711
•: Neoplastic Process

Synonyms:

Lepidic Predominant Adenocarcinoma; Lepidic Predominant Lung Adenocarcinoma

Definition

A lung adenocarcinoma characterized by the presence of mildly and moderately differentiated adenocarcinoma cells across the alveolar walls with at least one focus of invasive carcinoma measuring more than 5 mm in greatest dimension. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLepidic Adenocarcinoma

Disease
- Neoplasm
  - Epithelial neoplasm
    - Carcinoma
      - Adenocarcinoma
        Lung adenocarcinoma
        Lepidic Adenocarcinoma

Professional guidelines

PubMed

EGFR and ERBB2 Exon 20 Insertion Mutations in Chinese Non-small Cell Lung Cancer Patients: Pathological and Molecular Characterization, and First-Line Systemic Treatment Evaluation.

Zhao R, Li J, Guo L, Xiang C, Chen S, Zhao J, Shao J, Zhu L, Ye M, Qin G, Chu T, Han Y
Target Oncol 2024 Mar;19(2):277-288. Epub 2024 Feb 28 doi: 10.1007/s11523-024-01042-3. PMID: 38416376

New Morphologic Findings Support Invasiveness Criteria in Small-Sized Nonmucinous Lepidic Adenocarcinoma: Commenting a Proposal From the International Association for the Study of Lung Cancer Pathology Committee.

Visca P, Gallo E, Marino M
J Thorac Oncol 2023 Apr;18(4):387-389. doi: 10.1016/j.jtho.2023.01.001. PMID: 36990568

Pulmonary Adenocarcinomas of Low Malignant Potential: Proposed Criteria to Expand the Spectrum Beyond Adenocarcinoma In Situ and Minimally Invasive Adenocarcinoma.

Yambayev I, Sullivan TB, Suzuki K, Zhao Q, Higgins SE, Yilmaz OH, Litle VR, Moreira P, Servais EL, Stock CT, Quadri SM, Williamson C, Rieger-Christ KM, Burks EJ
Am J Surg Pathol 2021 Apr 1;45(4):567-576. doi: 10.1097/PAS.0000000000001618. PMID: 33177339

See all (3)

Recent clinical studies

Etiology

Feline pulmonary carcinoma: Gross, histological, metastatic, and immunohistochemical aspects.

Santos IR, Raiter J, Lamego ÉC, Bandinelli MB, Dal Pont TP, Siqueira KF, Almeida BA, Panzeira W, Sonne L, Driemeier D, Pavarini SP
Vet Pathol 2023 Jan;60(1):8-20. Epub 2022 Sep 13 doi: 10.1177/03009858221122517. PMID: 36112908

Commentary: Nodal Assessment in Lepidic Adenocarcinoma: Less is not More.

Starnes SL
Semin Thorac Cardiovasc Surg 2023 Summer;35(2):410-411. Epub 2022 Apr 2 doi: 10.1053/j.semtcvs.2022.03.007. PMID: 35381353

Characteristics and Prognostic Nomogram for Primary Lung Lepidic Adenocarcinoma.

Tang H, Qiao C, Wang Y, Bai C
Can Respir J 2022;2022:3676547. Epub 2022 Aug 31 doi: 10.1155/2022/3676547. PMID: 36091329 Free PMC Article

Unusual presentation of lepidic adenocarcinoma in a healthy female.

Akhtar Z, Laageide L, Robles J, Winters C, Wall GC, Mallen J, Jawa Z
BMC Pulm Med 2022 May 16;22(1):197. doi: 10.1186/s12890-022-01969-1. PMID: 35578218 Free PMC Article

Approach to the Subsolid Nodule.

Mase VJ Jr, Detterbeck FC
Clin Chest Med 2020 Mar;41(1):99-113. doi: 10.1016/j.ccm.2019.11.004. PMID: 32008632

See all (25)

Diagnosis

Detection of early (T1) lung cancers and lepidic adenocarcinomas in sputum and bronchial cytology.

Ng JKM, Cheung W, Li JJX, Chan KP, Yip WH, Tse GM
Ann Diagn Pathol 2023 Dec;67:152191. Epub 2023 Aug 10 doi: 10.1016/j.anndiagpath.2023.152191. PMID: 37579536

Lung transplantation for lung cancer: A systematic review of the literature.

Elsolh B, Bayat Z, Lyu D, Lin J, Wakeam E
J Heart Lung Transplant 2023 Oct;42(10):1425-1436. Epub 2023 May 28 doi: 10.1016/j.healun.2023.05.011. PMID: 37253398

Feline pulmonary carcinoma: Gross, histological, metastatic, and immunohistochemical aspects.

Characteristics and Prognostic Nomogram for Primary Lung Lepidic Adenocarcinoma.

Tang H, Qiao C, Wang Y, Bai C
Can Respir J 2022;2022:3676547. Epub 2022 Aug 31 doi: 10.1155/2022/3676547. PMID: 36091329 Free PMC Article

Approach to the Subsolid Nodule.

Mase VJ Jr, Detterbeck FC
Clin Chest Med 2020 Mar;41(1):99-113. doi: 10.1016/j.ccm.2019.11.004. PMID: 32008632

See all (20)

Therapy

Lung transplantation for lung cancer: A systematic review of the literature.

Elsolh B, Bayat Z, Lyu D, Lin J, Wakeam E
J Heart Lung Transplant 2023 Oct;42(10):1425-1436. Epub 2023 May 28 doi: 10.1016/j.healun.2023.05.011. PMID: 37253398

Complete Lymphadenectomy for Clinical Stage I Lepidic Adenocarcinoma of the Lung: Is it justified?

Maurizi G, D'Andrilli A, Argento G, Ciccone AM, Ibrahim M, Andreetti C, Vanni C, Tierno SM, Venuta F, Rendina EA
Semin Thorac Cardiovasc Surg 2023 Summer;35(2):399-409. Epub 2022 Mar 8 doi: 10.1053/j.semtcvs.2021.11.020. PMID: 35272026

Middle lobe syndrome: An exceptional presentation of concomitant lepidic adenocarcinoma and bronchial anthracofibrosis.

Kunal S, Jain S, Shah A
Monaldi Arch Chest Dis 2017 Dec 19;87(3):864. doi: 10.4081/monaldi.2017.864. PMID: 29424200

Survival and risk factors for progression after resection of the dominant tumor in multifocal, lepidic-type pulmonary adenocarcinoma.

Gao RW, Berry MF, Kunder CA, Khuong AA, Wakelee H, Neal JW, Backhus LM, Shrager JB
J Thorac Cardiovasc Surg 2017 Dec;154(6):2092-2099.e2. Epub 2017 Aug 1 doi: 10.1016/j.jtcvs.2017.07.034. PMID: 28863952

Erlotinib versus carboplatin and paclitaxel in advanced lepidic adenocarcinoma: IFCT-0504.

Cadranel J, Gervais R, Merle P, Moro-Sibilot D, Westeel V, Bigay-Game L, Quoix E, Friard S, Barlesi F, Lethrosne C, Moreau L, Monnet I, Salaun M, Oliviero G, Souquet PJ, Antoine M, Langlais A, Morin F, Wislez M, Zalcman G; Intergroupe Francophone de Cancérologie Thoracique (IFCT)
Eur Respir J 2015 Nov;46(5):1440-50. Epub 2015 Sep 17 doi: 10.1183/13993003.02358-2014. PMID: 26381515

See all (8)

Prognosis

Complete Lymphadenectomy for Clinical Stage I Lepidic Adenocarcinoma of the Lung: Is it justified?

Characteristics and Prognostic Nomogram for Primary Lung Lepidic Adenocarcinoma.

Tang H, Qiao C, Wang Y, Bai C
Can Respir J 2022;2022:3676547. Epub 2022 Aug 31 doi: 10.1155/2022/3676547. PMID: 36091329 Free PMC Article

Unusual presentation of lepidic adenocarcinoma in a healthy female.

Akhtar Z, Laageide L, Robles J, Winters C, Wall GC, Mallen J, Jawa Z
BMC Pulm Med 2022 May 16;22(1):197. doi: 10.1186/s12890-022-01969-1. PMID: 35578218 Free PMC Article

Role of PET/CT in Management of Early Lung Adenocarcinoma.

Shao X, Niu R, Jiang Z, Shao X, Wang Y
AJR Am J Roentgenol 2020 Feb;214(2):437-445. Epub 2019 Nov 12 doi: 10.2214/AJR.19.21585. PMID: 31714848

The Role of Extent of Surgical Resection and Lymph Node Assessment for Clinical Stage I Pulmonary Lepidic Adenocarcinoma: An Analysis of 1991 Patients.

Cox ML, Yang CJ, Speicher PJ, Anderson KL, Fitch ZW, Gu L, Davis RP, Wang X, D'Amico TA, Hartwig MG, Harpole DH Jr, Berry MF
J Thorac Oncol 2017 Apr;12(4):689-696. Epub 2017 Jan 8 doi: 10.1016/j.jtho.2017.01.003. PMID: 28082103 Free PMC Article

See all (17)

Clinical prediction guides

Feline pulmonary carcinoma: Gross, histological, metastatic, and immunohistochemical aspects.

Characteristics and Prognostic Nomogram for Primary Lung Lepidic Adenocarcinoma.

Tang H, Qiao C, Wang Y, Bai C
Can Respir J 2022;2022:3676547. Epub 2022 Aug 31 doi: 10.1155/2022/3676547. PMID: 36091329 Free PMC Article

Role of PET/CT in Management of Early Lung Adenocarcinoma.

Shao X, Niu R, Jiang Z, Shao X, Wang Y
AJR Am J Roentgenol 2020 Feb;214(2):437-445. Epub 2019 Nov 12 doi: 10.2214/AJR.19.21585. PMID: 31714848

A Proposal for Definition of Minimally Invasive Adenocarcinoma of the Lung Regardless of Tumor Size.

Suzuki S, Sakurai H, Masai K, Asakura K, Nakagawa K, Motoi N, Watanabe SI
Ann Thorac Surg 2017 Sep;104(3):1027-1032. Epub 2017 May 24 doi: 10.1016/j.athoracsur.2017.02.067. PMID: 28551046

The Role of Extent of Surgical Resection and Lymph Node Assessment for Clinical Stage I Pulmonary Lepidic Adenocarcinoma: An Analysis of 1991 Patients.

See all (8)

MedGen

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Lepidic Adenocarcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

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