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Lupus Flare

MedGen UID:
883752
•Concept ID:
C4054590
•
Disease or Syndrome

Definition

An exacerbation of the chronic disease lupus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLupus Flare

Professional guidelines

PubMed

Clinical management of Lupus patients during the COVID-19 pandemic.
Mason A, Rose E, Edwards CJ
Lupus 2020 Nov;29(13):1661-1672. Epub 2020 Oct 15 doi: 10.1177/0961203320961848. PMID: 33059530
Diagnosis and treatment of lupus nephritis flares--an update.
Sprangers B, Monahan M, Appel GB
Nat Rev Nephrol 2012 Dec;8(12):709-17. Epub 2012 Nov 13 doi: 10.1038/nrneph.2012.220. PMID: 23147758
Flares of systemic lupus erythematosus during pregnancy and the puerperium: prevention, diagnosis and management.
Stojan G, Baer AN
Expert Rev Clin Immunol 2012 Jul;8(5):439-53. doi: 10.1586/eci.12.36. PMID: 22882219

Recent clinical studies

Etiology

Pregnancy in patients with systemic lupus erythematosus: a systematic review.
Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558
Pregnancy and Systemic Lupus Erythematosus.
Petri M
Best Pract Res Clin Obstet Gynaecol 2020 Apr;64:24-30. Epub 2019 Oct 8 doi: 10.1016/j.bpobgyn.2019.09.002. PMID: 31677989
Urinary mRNA and lupus disease flare.
Szeto CC
Nephrology (Carlton) 2017 Dec;22 Suppl 4:27-30. doi: 10.1111/nep.13151. PMID: 29155501
A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis.
Smyth A, Oliveira GH, Lahr BD, Bailey KR, Norby SM, Garovic VD
Clin J Am Soc Nephrol 2010 Nov;5(11):2060-8. Epub 2010 Aug 5 doi: 10.2215/CJN.00240110. PMID: 20688887Free PMC Article
Combined oral contraceptives in women with systemic lupus erythematosus.
Petri M, Kim MY, Kalunian KC, Grossman J, Hahn BH, Sammaritano LR, Lockshin M, Merrill JT, Belmont HM, Askanase AD, McCune WJ, Hearth-Holmes M, Dooley MA, Von Feldt J, Friedman A, Tan M, Davis J, Cronin M, Diamond B, Mackay M, Sigler L, Fillius M, Rupel A, Licciardi F, Buyon JP; OC-SELENA Trial
N Engl J Med 2005 Dec 15;353(24):2550-8. doi: 10.1056/NEJMoa051135. PMID: 16354891

Diagnosis

Lupus erythematosus: Significance of dermatologic findings.
Lenormand C, Lipsker D
Ann Dermatol Venereol 2021 Mar;148(1):6-15. Epub 2021 Jan 19 doi: 10.1016/j.annder.2020.08.052. PMID: 33483145
Urinary mRNA and lupus disease flare.
Szeto CC
Nephrology (Carlton) 2017 Dec;22 Suppl 4:27-30. doi: 10.1111/nep.13151. PMID: 29155501
Biomarkers for systemic lupus erythematosus.
Ahearn JM, Liu CC, Kao AH, Manzi S
Transl Res 2012 Apr;159(4):326-42. Epub 2012 Feb 10 doi: 10.1016/j.trsl.2012.01.021. PMID: 22424435
Lupus and pregnancy.
Baer AN, Witter FR, Petri M
Obstet Gynecol Surv 2011 Oct;66(10):639-53. doi: 10.1097/OGX.0b013e318239e1ee. PMID: 22112525
SLE and infections.
Zandman-Goddard G, Shoenfeld Y
Clin Rev Allergy Immunol 2003 Aug;25(1):29-40. doi: 10.1385/CRIAI:25:1:29. PMID: 12794259

Therapy

Pregnancy in patients with systemic lupus erythematosus: a systematic review.
Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558
Safety and efficacy of the SGLT2 inhibitor dapagliflozin in patients with systemic lupus erythematosus: a phase I/II trial.
Wang H, Li T, Sun F, Liu Z, Zhang D, Teng X, Morel L, Wang X, Ye S
RMD Open 2022 Oct;8(2) doi: 10.1136/rmdopen-2022-002686. PMID: 36288823Free PMC Article
Pregnancy and Systemic Lupus Erythematosus.
Petri M
Best Pract Res Clin Obstet Gynaecol 2020 Apr;64:24-30. Epub 2019 Oct 8 doi: 10.1016/j.bpobgyn.2019.09.002. PMID: 31677989
A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis.
Smyth A, Oliveira GH, Lahr BD, Bailey KR, Norby SM, Garovic VD
Clin J Am Soc Nephrol 2010 Nov;5(11):2060-8. Epub 2010 Aug 5 doi: 10.2215/CJN.00240110. PMID: 20688887Free PMC Article
Combined oral contraceptives in women with systemic lupus erythematosus.
Petri M, Kim MY, Kalunian KC, Grossman J, Hahn BH, Sammaritano LR, Lockshin M, Merrill JT, Belmont HM, Askanase AD, McCune WJ, Hearth-Holmes M, Dooley MA, Von Feldt J, Friedman A, Tan M, Davis J, Cronin M, Diamond B, Mackay M, Sigler L, Fillius M, Rupel A, Licciardi F, Buyon JP; OC-SELENA Trial
N Engl J Med 2005 Dec 15;353(24):2550-8. doi: 10.1056/NEJMoa051135. PMID: 16354891

Prognosis

Pregnancy in patients with systemic lupus erythematosus: a systematic review.
Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558
Lupus erythematosus: Significance of dermatologic findings.
Lenormand C, Lipsker D
Ann Dermatol Venereol 2021 Mar;148(1):6-15. Epub 2021 Jan 19 doi: 10.1016/j.annder.2020.08.052. PMID: 33483145
Pregnancy and Systemic Lupus Erythematosus.
Petri M
Best Pract Res Clin Obstet Gynaecol 2020 Apr;64:24-30. Epub 2019 Oct 8 doi: 10.1016/j.bpobgyn.2019.09.002. PMID: 31677989
Urinary mRNA and lupus disease flare.
Szeto CC
Nephrology (Carlton) 2017 Dec;22 Suppl 4:27-30. doi: 10.1111/nep.13151. PMID: 29155501
Biomarkers for systemic lupus erythematosus.
Ahearn JM, Liu CC, Kao AH, Manzi S
Transl Res 2012 Apr;159(4):326-42. Epub 2012 Feb 10 doi: 10.1016/j.trsl.2012.01.021. PMID: 22424435

Clinical prediction guides

Pregnancy in patients with systemic lupus erythematosus: a systematic review.
Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558
Safety and efficacy of the SGLT2 inhibitor dapagliflozin in patients with systemic lupus erythematosus: a phase I/II trial.
Wang H, Li T, Sun F, Liu Z, Zhang D, Teng X, Morel L, Wang X, Ye S
RMD Open 2022 Oct;8(2) doi: 10.1136/rmdopen-2022-002686. PMID: 36288823Free PMC Article
Biochemical and clinical predictors in pregnant women with antiphospholipid syndrome and systemic lupus erythematosus: comprehensive update.
Li X, Shopit A, Wang J
Arch Gynecol Obstet 2021 Nov;304(5):1153-1160. Epub 2021 Aug 14 doi: 10.1007/s00404-021-06178-5. PMID: 34390384
Pregnancy and Systemic Lupus Erythematosus.
Petri M
Best Pract Res Clin Obstet Gynaecol 2020 Apr;64:24-30. Epub 2019 Oct 8 doi: 10.1016/j.bpobgyn.2019.09.002. PMID: 31677989
Urinary mRNA and lupus disease flare.
Szeto CC
Nephrology (Carlton) 2017 Dec;22 Suppl 4:27-30. doi: 10.1111/nep.13151. PMID: 29155501

Recent systematic reviews

Pregnancy in patients with systemic lupus erythematosus: a systematic review.
Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558
Comparison Between Hemodialysis and Peritoneal Dialysis in the Risks for Disease Activity in LN-ESRD Patients: A Systematic Review and Meta-analysis.
Gong Y, Zhao Y, Ran L, Liu Y
Altern Ther Health Med 2022 Sep;28(6):144-149. PMID: 35648699
Systematic review and meta-analysis of clinical outcomes comparison between different initial dialysis modalities in end-stage renal disease patients due to lupus nephritis prior to renal transplantation.
Swai J, Zhao X, Noube JR, Ming G
BMC Nephrol 2020 May 1;21(1):156. doi: 10.1186/s12882-020-01811-y. PMID: 32357924Free PMC Article
Disease activity in systemic lupus erythematosus patients with end-stage renal disease: systematic review of the literature.
Mattos P, Santiago MB
Clin Rheumatol 2012 Jun;31(6):897-905. Epub 2012 Mar 14 doi: 10.1007/s10067-012-1957-9. PMID: 22415467
A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis.
Smyth A, Oliveira GH, Lahr BD, Bailey KR, Norby SM, Garovic VD
Clin J Am Soc Nephrol 2010 Nov;5(11):2060-8. Epub 2010 Aug 5 doi: 10.2215/CJN.00240110. PMID: 20688887Free PMC Article

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