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Lymphocytic Neurohypophysitis

MedGen UID:
883757
•Concept ID:
C4054588
•
Disease or Syndrome

Definition

An autoimmune condition affecting the posterior pituitary gland, which is characterized by lymphocytic infiltration, and which often presents as diabetes insipidus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphocytic Neurohypophysitis

Recent clinical studies

Etiology

Longitudinal study of vasopressin-cell antibodies and of hypothalamic-pituitary region on magnetic resonance imaging in patients with autoimmune and idiopathic complete central diabetes insipidus.
De Bellis A, Colao A, Bizzarro A, Di Salle F, Coronella C, Solimeno S, Vetrano A, Pivonello R, Pisano G, Lombardi G, Bellastella A
J Clin Endocrinol Metab 2002 Aug;87(8):3825-9. doi: 10.1210/jcem.87.8.8757. PMID: 12161517

Diagnosis

Neuroimaging of hypophysitis: etiologies and imaging mimics.
Kurokawa R, Kurokawa M, Baba A, Nakaya M, Kato S, Bapuraj J, Nakata Y, Ota Y, Srinivasan A, Abe O, Moritani T
Jpn J Radiol 2023 Sep;41(9):911-927. Epub 2023 Apr 3 doi: 10.1007/s11604-023-01417-y. PMID: 37010787Free PMC Article
Neuropathology of Pituitary Adenomas and Sellar Lesions.
Kobalka PJ, Huntoon K, Becker AP
Neurosurgery 2021 Apr 15;88(5):900-918. doi: 10.1093/neuros/nyaa548. PMID: 33476394
Review on Recent Topics in Hypophysitis.
Sugihara H
J Nippon Med Sch 2017;84(5):201-208. doi: 10.1272/jnms.84.201. PMID: 29142180
Lymphocytic infundibulo-neurohypophysitis: a clinical overview.
Johnston PC, Chew LS, Hamrahian AH, Kennedy L
Endocrine 2015 Dec;50(3):531-6. Epub 2015 Jul 29 doi: 10.1007/s12020-015-0707-6. PMID: 26219407
Pituitary autoimmune disease: nuances in clinical presentation.
Glezer A, Bronstein MD
Endocrine 2012 Aug;42(1):74-9. Epub 2012 Mar 17 doi: 10.1007/s12020-012-9654-7. PMID: 22426958

Therapy

Pituitary stalk thickening in patients under 18 years of age - the most common causes and diagnostic procedures.
Moszczyńska E, Baszyńska-Wilk M, Zasada K, Majak D, Szaniawska M, Szalecki M
Pediatr Endocrinol Diabetes Metab 2022;28(3):213-227. doi: 10.5114/pedm.2022.115202. PMID: 35620922Free PMC Article
Fatal fulminant hepatitis induced by combined ipilimumab and nivolumab therapy despite favorable histologic response and confirmed by autopsy in a patient with clear cell renal cell carcinoma.
Kubo T, Sugawara T, Shinkawa T, Kurisu T, Kouzen N, Tanaka T, Fukuta F, Yamasaki K, Sugita S, Matsuo K, Morita R, Hirohashi Y, Tsukahara T, Kanaseki T, Hasegawa T, Masumori N, Torigoe T
Immunol Med 2021 Jun;44(2):136-141. Epub 2020 Jul 7 doi: 10.1080/25785826.2020.1788229. PMID: 32634346
Anti-pituitary antibodies as a marker of autoimmunity in pituitary glands.
Iwama S, Arima H
Endocr J 2020 Nov 28;67(11):1077-1083. Epub 2020 Oct 14 doi: 10.1507/endocrj.EJ20-0436. PMID: 33055452
Review on Recent Topics in Hypophysitis.
Sugihara H
J Nippon Med Sch 2017;84(5):201-208. doi: 10.1272/jnms.84.201. PMID: 29142180
Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis.
Iwata N, Iwama S, Sugimura Y, Yasuda Y, Nakashima K, Takeuchi S, Hagiwara D, Ito Y, Suga H, Goto M, Banno R, Caturegli P, Koike T, Oshida Y, Arima H
Pituitary 2017 Jun;20(3):301-310. doi: 10.1007/s11102-016-0780-8. PMID: 27896569

Prognosis

Review on Recent Topics in Hypophysitis.
Sugihara H
J Nippon Med Sch 2017;84(5):201-208. doi: 10.1272/jnms.84.201. PMID: 29142180
Variant of lymphocytic infundibulo-neurohypophysitis presenting with unique clinical and radiological features.
Seki T, Yasuda A, Yamaoka T, Imai J, Ito K, Ozawa H, Fukagawa M, Okamatsu C, Nakamura N, Atsumi H, Matsumae M, Takagi A
Tokai J Exp Clin Med 2012 Dec 20;37(4):126-32. PMID: 23238905
Transient polyuria related to central diabetes insipidus caused by lymphocytic infundibulo-neurohypophysitis in a patient treated for Graves' disease.
Yamazaki M, Sato A, Nishio S, Uehara T, Komatsu M
Intern Med 2010;49(17):1885-90. Epub 2010 Sep 1 doi: 10.2169/internalmedicine.49.3381. PMID: 20823651
Lymphocytic infundibulo-neurohypophysitis and infundibulo-panhypophysitis regarded as lymphocytic hypophysitis variant.
Abe T
Brain Tumor Pathol 2008;25(2):59-66. Epub 2008 Nov 6 doi: 10.1007/s10014-008-0234-8. PMID: 18987830
Longitudinal study of vasopressin-cell antibodies and of hypothalamic-pituitary region on magnetic resonance imaging in patients with autoimmune and idiopathic complete central diabetes insipidus.
De Bellis A, Colao A, Bizzarro A, Di Salle F, Coronella C, Solimeno S, Vetrano A, Pivonello R, Pisano G, Lombardi G, Bellastella A
J Clin Endocrinol Metab 2002 Aug;87(8):3825-9. doi: 10.1210/jcem.87.8.8757. PMID: 12161517

Clinical prediction guides

Usefulness of anti-rabphilin-3A antibodies for diagnosing central diabetes insipidus in the third trimester of pregnancy.
Sakurai K, Yamashita R, Niituma S, Iwama S, Sugimura Y, Arihara Z, Takahashi K
Endocr J 2017 Jun 29;64(6):645-650. Epub 2017 Apr 14 doi: 10.1507/endocrj.EJ17-0028. PMID: 28420857
Variant of lymphocytic infundibulo-neurohypophysitis presenting with unique clinical and radiological features.
Seki T, Yasuda A, Yamaoka T, Imai J, Ito K, Ozawa H, Fukagawa M, Okamatsu C, Nakamura N, Atsumi H, Matsumae M, Takagi A
Tokai J Exp Clin Med 2012 Dec 20;37(4):126-32. PMID: 23238905
A rare case of central post-gravid diabetes insipidus.
Morrone LF, Saracino A, Ramunni A, Fasianos E, Coratelli P, Passavanti G
Clin Nephrol 2003 Dec;60(6):433-6. doi: 10.5414/cnp60433. PMID: 14690263
Longitudinal study of vasopressin-cell antibodies and of hypothalamic-pituitary region on magnetic resonance imaging in patients with autoimmune and idiopathic complete central diabetes insipidus.
De Bellis A, Colao A, Bizzarro A, Di Salle F, Coronella C, Solimeno S, Vetrano A, Pivonello R, Pisano G, Lombardi G, Bellastella A
J Clin Endocrinol Metab 2002 Aug;87(8):3825-9. doi: 10.1210/jcem.87.8.8757. PMID: 12161517

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