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Calcineurin Inhibitor - Induced Nephropathy

MedGen UID:
883866
•Concept ID:
C4053745
•
Disease or Syndrome

Definition

Kidney damage resulting from exposure to calcineurin inhibitors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCalcineurin Inhibitor - Induced Nephropathy

Professional guidelines

PubMed

Principles of Immunosuppression in the Management of Kidney Disease: Core Curriculum 2022.
Kant S, Kronbichler A, Geetha D
Am J Kidney Dis 2022 Sep;80(3):393-405. Epub 2022 Apr 16 doi: 10.1053/j.ajkd.2021.12.011. PMID: 35440396
Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome.
von Groote TC, Williams G, Au EH, Chen Y, Mathew AT, Hodson EM, Tunnicliffe DJ
Cochrane Database Syst Rev 2021 Nov 15;11(11):CD004293. doi: 10.1002/14651858.CD004293.pub4. PMID: 34778952Free PMC Article
Management of toxicities of immune checkpoint inhibitors.
Spain L, Diem S, Larkin J
Cancer Treat Rev 2016 Mar;44:51-60. Epub 2016 Feb 6 doi: 10.1016/j.ctrv.2016.02.001. PMID: 26874776

Recent clinical studies

Etiology

Principles of Immunosuppression in the Management of Kidney Disease: Core Curriculum 2022.
Kant S, Kronbichler A, Geetha D
Am J Kidney Dis 2022 Sep;80(3):393-405. Epub 2022 Apr 16 doi: 10.1053/j.ajkd.2021.12.011. PMID: 35440396
Membranous nephropathy.
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Cellular aspects of the pathogenesis of lupus nephritis.
Chang A, Clark MR, Ko K
Curr Opin Rheumatol 2021 Mar 1;33(2):197-204. doi: 10.1097/BOR.0000000000000777. PMID: 33394604Free PMC Article
Mineralocorticoid receptor antagonists and kidney diseases: pathophysiological basis.
Barrera-Chimal J, Girerd S, Jaisser F
Kidney Int 2019 Aug;96(2):302-319. Epub 2019 Mar 13 doi: 10.1016/j.kint.2019.02.030. PMID: 31133455
Calcineurin inhibitor nephrotoxicity.
Naesens M, Kuypers DR, Sarwal M
Clin J Am Soc Nephrol 2009 Feb;4(2):481-508. doi: 10.2215/CJN.04800908. PMID: 19218475

Diagnosis

Non-steroidal Anti-inflammatory Drugs: Clinical Implications, Renal Impairment Risks, and AKI.
LaForge JM, Urso K, Day JM, Bourgeois CW, Ross MM, Ahmadzadeh S, Shekoohi S, Cornett EM, Kaye AM, Kaye AD
Adv Ther 2023 May;40(5):2082-2096. Epub 2023 Mar 22 doi: 10.1007/s12325-023-02481-6. PMID: 36947330
Nephrotic Syndrome.
Rodriguez-Ballestas E, Reid-Adam J
Pediatr Rev 2022 Feb 1;43(2):87-99. doi: 10.1542/pir.2020-001230. PMID: 35102405
Membranous nephropathy.
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Immunosuppression-related neurological disorders in kidney transplantation.
Faravelli I, Velardo D, Podestà MA, Ponticelli C
J Nephrol 2021 Apr;34(2):539-555. Epub 2021 Jan 22 doi: 10.1007/s40620-020-00956-1. PMID: 33481222Free PMC Article
Calcineurin inhibitor nephrotoxicity.
Naesens M, Kuypers DR, Sarwal M
Clin J Am Soc Nephrol 2009 Feb;4(2):481-508. doi: 10.2215/CJN.04800908. PMID: 19218475

Therapy

Principles of Immunosuppression in the Management of Kidney Disease: Core Curriculum 2022.
Kant S, Kronbichler A, Geetha D
Am J Kidney Dis 2022 Sep;80(3):393-405. Epub 2022 Apr 16 doi: 10.1053/j.ajkd.2021.12.011. PMID: 35440396
Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome.
von Groote TC, Williams G, Au EH, Chen Y, Mathew AT, Hodson EM, Tunnicliffe DJ
Cochrane Database Syst Rev 2021 Nov 15;11(11):CD004293. doi: 10.1002/14651858.CD004293.pub4. PMID: 34778952Free PMC Article
Membranous nephropathy.
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Mineralocorticoid receptor antagonists and kidney diseases: pathophysiological basis.
Barrera-Chimal J, Girerd S, Jaisser F
Kidney Int 2019 Aug;96(2):302-319. Epub 2019 Mar 13 doi: 10.1016/j.kint.2019.02.030. PMID: 31133455
Calcineurin inhibitor nephrotoxicity.
Naesens M, Kuypers DR, Sarwal M
Clin J Am Soc Nephrol 2009 Feb;4(2):481-508. doi: 10.2215/CJN.04800908. PMID: 19218475

Prognosis

Non-steroidal Anti-inflammatory Drugs: Clinical Implications, Renal Impairment Risks, and AKI.
LaForge JM, Urso K, Day JM, Bourgeois CW, Ross MM, Ahmadzadeh S, Shekoohi S, Cornett EM, Kaye AM, Kaye AD
Adv Ther 2023 May;40(5):2082-2096. Epub 2023 Mar 22 doi: 10.1007/s12325-023-02481-6. PMID: 36947330
Nephrotic Syndrome.
Rodriguez-Ballestas E, Reid-Adam J
Pediatr Rev 2022 Feb 1;43(2):87-99. doi: 10.1542/pir.2020-001230. PMID: 35102405
Membranous nephropathy.
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Cellular aspects of the pathogenesis of lupus nephritis.
Chang A, Clark MR, Ko K
Curr Opin Rheumatol 2021 Mar 1;33(2):197-204. doi: 10.1097/BOR.0000000000000777. PMID: 33394604Free PMC Article
Calcineurin inhibitors and nephrotoxicity in children.
Liu F, Mao JH
World J Pediatr 2018 Apr;14(2):121-126. Epub 2018 Mar 12 doi: 10.1007/s12519-018-0125-y. PMID: 29532435

Clinical prediction guides

Membranous nephropathy.
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Cellular aspects of the pathogenesis of lupus nephritis.
Chang A, Clark MR, Ko K
Curr Opin Rheumatol 2021 Mar 1;33(2):197-204. doi: 10.1097/BOR.0000000000000777. PMID: 33394604Free PMC Article
The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy.
Fernández-Juárez G, Rojas-Rivera J, Logt AV, Justino J, Sevillano A, Caravaca-Fontán F, Ávila A, Rabasco C, Cabello V, Varela A, Díez M, Martín-Reyes G, Diezhandino MG, Quintana LF, Agraz I, Gómez-Martino JR, Cao M, Rodríguez-Moreno A, Rivas B, Galeano C, Bonet J, Romera A, Shabaka A, Plaisier E, Espinosa M, Egido J, Segarra A, Lambeau G, Ronco P, Wetzels J, Praga M; STARMEN Investigators
Kidney Int 2021 Apr;99(4):986-998. Epub 2020 Nov 7 doi: 10.1016/j.kint.2020.10.014. PMID: 33166580
Mineralocorticoid receptor antagonists and kidney diseases: pathophysiological basis.
Barrera-Chimal J, Girerd S, Jaisser F
Kidney Int 2019 Aug;96(2):302-319. Epub 2019 Mar 13 doi: 10.1016/j.kint.2019.02.030. PMID: 31133455
B cell suppression in primary glomerular disease.
Rood IM, Hofstra JM, Deegens JK, Wetzels JF
Adv Chronic Kidney Dis 2014 Mar;21(2):166-81. doi: 10.1053/j.ackd.2014.01.005. PMID: 24602466

Recent systematic reviews

Interventions for minimal change disease in adults with nephrotic syndrome.
Azukaitis K, Palmer SC, Strippoli GF, Hodson EM
Cochrane Database Syst Rev 2022 Mar 1;3(3):CD001537. doi: 10.1002/14651858.CD001537.pub5. PMID: 35230699Free PMC Article
Immunosuppression therapy for idiopathic membranous nephropathy: systematic review with network meta-analysis.
Bose B, Chung EYM, Hong R, Strippoli GFM, Johnson DW, Yang WL, Badve SV, Palmer SC
J Nephrol 2022 May;35(4):1159-1170. Epub 2022 Feb 23 doi: 10.1007/s40620-022-01268-2. PMID: 35199314Free PMC Article
Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome.
von Groote TC, Williams G, Au EH, Chen Y, Mathew AT, Hodson EM, Tunnicliffe DJ
Cochrane Database Syst Rev 2021 Nov 15;11(11):CD004293. doi: 10.1002/14651858.CD004293.pub4. PMID: 34778952Free PMC Article
Immunosuppressive treatment for proliferative lupus nephritis.
Tunnicliffe DJ, Palmer SC, Henderson L, Masson P, Craig JC, Tong A, Singh-Grewal D, Flanc RS, Roberts MA, Webster AC, Strippoli GF
Cochrane Database Syst Rev 2018 Jun 29;6(6):CD002922. doi: 10.1002/14651858.CD002922.pub4. PMID: 29957821Free PMC Article
Risk factors for calcineurin inhibitor nephrotoxicity after renal transplantation: a systematic review and meta-analysis.
Xia T, Zhu S, Wen Y, Gao S, Li M, Tao X, Zhang F, Chen W
Drug Des Devel Ther 2018;12:417-428. Epub 2018 Feb 28 doi: 10.2147/DDDT.S149340. PMID: 29535503Free PMC Article

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